The Prognostic Values of PARP-1 Expression in Uveal Melanoma
Background: Uveal melanoma is the most common primary intraocular malignancy in adults. In advanced cases, the prognosis is very poor. Thus far, no effective methods of pharmacotherapy of this cancer have been found. The aim of the study was to evaluate the expression of PARP-1, the best-known membe...
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MDPI AG
2021-01-01
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| Online Access: | https://www.mdpi.com/2073-4409/10/2/285 |
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| author | Malgorzata Gajdzis Stamatios Theocharis Jerzy Klijanienko Nathalie Cassoux Sophie Gardrat Piotr Donizy Radoslaw Kaczmarek Pawel Gajdzis |
| author_facet | Malgorzata Gajdzis Stamatios Theocharis Jerzy Klijanienko Nathalie Cassoux Sophie Gardrat Piotr Donizy Radoslaw Kaczmarek Pawel Gajdzis |
| author_sort | Malgorzata Gajdzis |
| collection | DOAJ |
| description | Background: Uveal melanoma is the most common primary intraocular malignancy in adults. In advanced cases, the prognosis is very poor. Thus far, no effective methods of pharmacotherapy of this cancer have been found. The aim of the study was to evaluate the expression of PARP-1, the best-known member of the family of poly(ADP-ribose) polymerases, in uveal melanoma and its associations with clinicopathological parameters, overall survival, and disease-free survival. Methods: The study included 91 patients who underwent enucleation due to uveal melanoma. PARP-1 expression was assessed by immunohistochemistry. Results: High PARP-1 expression was associated with more frequent chromosome 3 loss, higher histopathological grade, bigger tumor size, and absence of intrascleral extension. High PARP-1 expression was associated with shorter overall survival time and disease-free survival time. Conclusions: The above findings indicate that high expression of PARP-1 can be considered as an unfavorable prognostic factor in uveal melanoma. |
| first_indexed | 2024-03-09T06:19:54Z |
| format | Article |
| id | doaj.art-910f446a1765437594d0fd73e1256fba |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-09T06:19:54Z |
| publishDate | 2021-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-910f446a1765437594d0fd73e1256fba2023-12-03T11:49:25ZengMDPI AGCells2073-44092021-01-0110228510.3390/cells10020285The Prognostic Values of PARP-1 Expression in Uveal MelanomaMalgorzata Gajdzis0Stamatios Theocharis1Jerzy Klijanienko2Nathalie Cassoux3Sophie Gardrat4Piotr Donizy5Radoslaw Kaczmarek6Pawel Gajdzis7Department of Ophthalmology, Wroclaw Medical University, 50-556 Wroclaw, PolandFirst Department of Pathology, National and Kapodistrian University of Athens, 15772 Athens, GreeceDepartment of Pathology, Curie Institute, 75005 Paris, FranceDepartment of Ophthalmology, Institut Curie, 75005 Paris, FranceDepartment of Biopathology, Institut Curie, PSL Research University, 75005 Paris, FranceDepartment of Pathomorphology and Oncological Cytology, Wroclaw Medical University, 50-556 Wroclaw, PolandDepartment of Ophthalmology, Wroclaw Medical University, 50-556 Wroclaw, PolandDepartment of Pathology, Curie Institute, 75005 Paris, FranceBackground: Uveal melanoma is the most common primary intraocular malignancy in adults. In advanced cases, the prognosis is very poor. Thus far, no effective methods of pharmacotherapy of this cancer have been found. The aim of the study was to evaluate the expression of PARP-1, the best-known member of the family of poly(ADP-ribose) polymerases, in uveal melanoma and its associations with clinicopathological parameters, overall survival, and disease-free survival. Methods: The study included 91 patients who underwent enucleation due to uveal melanoma. PARP-1 expression was assessed by immunohistochemistry. Results: High PARP-1 expression was associated with more frequent chromosome 3 loss, higher histopathological grade, bigger tumor size, and absence of intrascleral extension. High PARP-1 expression was associated with shorter overall survival time and disease-free survival time. Conclusions: The above findings indicate that high expression of PARP-1 can be considered as an unfavorable prognostic factor in uveal melanoma.https://www.mdpi.com/2073-4409/10/2/285PARPPARP-1uveal melanomaimmunohistochemistry |
| spellingShingle | Malgorzata Gajdzis Stamatios Theocharis Jerzy Klijanienko Nathalie Cassoux Sophie Gardrat Piotr Donizy Radoslaw Kaczmarek Pawel Gajdzis The Prognostic Values of PARP-1 Expression in Uveal Melanoma Cells PARP PARP-1 uveal melanoma immunohistochemistry |
| title | The Prognostic Values of PARP-1 Expression in Uveal Melanoma |
| title_full | The Prognostic Values of PARP-1 Expression in Uveal Melanoma |
| title_fullStr | The Prognostic Values of PARP-1 Expression in Uveal Melanoma |
| title_full_unstemmed | The Prognostic Values of PARP-1 Expression in Uveal Melanoma |
| title_short | The Prognostic Values of PARP-1 Expression in Uveal Melanoma |
| title_sort | prognostic values of parp 1 expression in uveal melanoma |
| topic | PARP PARP-1 uveal melanoma immunohistochemistry |
| url | https://www.mdpi.com/2073-4409/10/2/285 |
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