Circulating MicroRNA‐122 and Fibrosis Stage Predict Mortality of Japanese Patients With Histopathologically Confirmed NAFLD
The impact of circulating microRNA‐122 (miR‐122) on mortality in patients with histopathologically confirmed nonalcoholic fatty liver disease (NAFLD) remains unclear. We analyzed the overall survival rates in 441 Japanese patients with histopathologically confirmed NAFLD after a median follow‐up per...
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Health/LWW
2020-01-01
|
| Series: | Hepatology Communications |
| Online Access: | https://doi.org/10.1002/hep4.1445 |
| _version_ | 1828044871571603456 |
|---|---|
| author | Norio Akuta Yusuke Kawamura Yasuji Arase Satoshi Saitoh Shunichiro Fujiyama Hitomi Sezaki Tetsuya Hosaka Masahiro Kobayashi Mariko Kobayashi Yoshiyuki Suzuki Fumitaka Suzuki Kenji Ikeda Hiromitsu Kumada |
| author_facet | Norio Akuta Yusuke Kawamura Yasuji Arase Satoshi Saitoh Shunichiro Fujiyama Hitomi Sezaki Tetsuya Hosaka Masahiro Kobayashi Mariko Kobayashi Yoshiyuki Suzuki Fumitaka Suzuki Kenji Ikeda Hiromitsu Kumada |
| author_sort | Norio Akuta |
| collection | DOAJ |
| description | The impact of circulating microRNA‐122 (miR‐122) on mortality in patients with histopathologically confirmed nonalcoholic fatty liver disease (NAFLD) remains unclear. We analyzed the overall survival rates in 441 Japanese patients with histopathologically confirmed NAFLD after a median follow‐up period of 4.7 years. We also determined the clinicopathologic, genetic, and epigenetic parameters, including serum miR‐122 levels, for prediction of mortality. Of the 441 study patients, 21 (4.8%) died during the follow‐up period. The cumulative survival rates were 95.4% and 90.6% at the end of 5 and 10 years, respectively. Multivariate analysis identified history of liver cancer (presence; hazard ratio [HR], 4.94; 95% confidence interval [CI], 1.84‐13.3), serum miR‐122 (<1.00 fold change; HR, 4.35; 95% CI, 0.06‐0.83), and fibrosis‐4 index (FIB‐4 index) (≥1.30; HR, 15.7; 95% CI, 2.01‐122) as significant risk factors of mortality. Cumulative survival rates varied significantly among patients with none/one risk factor, two risk factors, and three risk factors; particularly, the survival rate of patients with three risk factors was significantly lower than those with two risk factors and none/one risk factor. Two or more risk factors were identified in 17 of 21 (81.0%) death cases. Conclusion: The importance of serum miR‐122 and FIB‐4 index as risk factors for mortality in Japanese patients with histopathologically confirmed NAFLD is shown. Early diagnosis based on the presence of more than one risk factor and early treatment might improve the prognosis. |
| first_indexed | 2024-04-10T18:01:48Z |
| format | Article |
| id | doaj.art-91103ab7d4ab4b21ba0f77a0a920990f |
| institution | Directory Open Access Journal |
| issn | 2471-254X |
| language | English |
| last_indexed | 2024-04-10T18:01:48Z |
| publishDate | 2020-01-01 |
| publisher | Wolters Kluwer Health/LWW |
| record_format | Article |
| series | Hepatology Communications |
| spelling | doaj.art-91103ab7d4ab4b21ba0f77a0a920990f2023-02-02T15:08:51ZengWolters Kluwer Health/LWWHepatology Communications2471-254X2020-01-0141667610.1002/hep4.1445Circulating MicroRNA‐122 and Fibrosis Stage Predict Mortality of Japanese Patients With Histopathologically Confirmed NAFLDNorio Akuta0Yusuke Kawamura1Yasuji Arase2Satoshi Saitoh3Shunichiro Fujiyama4Hitomi Sezaki5Tetsuya Hosaka6Masahiro Kobayashi7Mariko Kobayashi8Yoshiyuki Suzuki9Fumitaka Suzuki10Kenji Ikeda11Hiromitsu Kumada12Department of Hepatology Toranomon Hospital and Okinaka Memorial Institute for Medical Research Tokyo JapanDepartment of Hepatology Toranomon Hospital and Okinaka Memorial Institute for Medical Research Tokyo JapanDepartment of Hepatology Toranomon Hospital and Okinaka Memorial Institute for Medical Research Tokyo JapanDepartment of Hepatology Toranomon Hospital and Okinaka Memorial Institute for Medical Research Tokyo JapanDepartment of Hepatology Toranomon Hospital and Okinaka Memorial Institute for Medical Research Tokyo JapanDepartment of Hepatology Toranomon Hospital and Okinaka Memorial Institute for Medical Research Tokyo JapanDepartment of Hepatology Toranomon Hospital and Okinaka Memorial Institute for Medical Research Tokyo JapanDepartment of Hepatology Toranomon Hospital and Okinaka Memorial Institute for Medical Research Tokyo JapanLiver Research Laboratory Toranomon Hospital Tokyo JapanDepartment of Hepatology Toranomon Hospital and Okinaka Memorial Institute for Medical Research Tokyo JapanDepartment of Hepatology Toranomon Hospital and Okinaka Memorial Institute for Medical Research Tokyo JapanDepartment of Hepatology Toranomon Hospital and Okinaka Memorial Institute for Medical Research Tokyo JapanDepartment of Hepatology Toranomon Hospital and Okinaka Memorial Institute for Medical Research Tokyo JapanThe impact of circulating microRNA‐122 (miR‐122) on mortality in patients with histopathologically confirmed nonalcoholic fatty liver disease (NAFLD) remains unclear. We analyzed the overall survival rates in 441 Japanese patients with histopathologically confirmed NAFLD after a median follow‐up period of 4.7 years. We also determined the clinicopathologic, genetic, and epigenetic parameters, including serum miR‐122 levels, for prediction of mortality. Of the 441 study patients, 21 (4.8%) died during the follow‐up period. The cumulative survival rates were 95.4% and 90.6% at the end of 5 and 10 years, respectively. Multivariate analysis identified history of liver cancer (presence; hazard ratio [HR], 4.94; 95% confidence interval [CI], 1.84‐13.3), serum miR‐122 (<1.00 fold change; HR, 4.35; 95% CI, 0.06‐0.83), and fibrosis‐4 index (FIB‐4 index) (≥1.30; HR, 15.7; 95% CI, 2.01‐122) as significant risk factors of mortality. Cumulative survival rates varied significantly among patients with none/one risk factor, two risk factors, and three risk factors; particularly, the survival rate of patients with three risk factors was significantly lower than those with two risk factors and none/one risk factor. Two or more risk factors were identified in 17 of 21 (81.0%) death cases. Conclusion: The importance of serum miR‐122 and FIB‐4 index as risk factors for mortality in Japanese patients with histopathologically confirmed NAFLD is shown. Early diagnosis based on the presence of more than one risk factor and early treatment might improve the prognosis.https://doi.org/10.1002/hep4.1445 |
| spellingShingle | Norio Akuta Yusuke Kawamura Yasuji Arase Satoshi Saitoh Shunichiro Fujiyama Hitomi Sezaki Tetsuya Hosaka Masahiro Kobayashi Mariko Kobayashi Yoshiyuki Suzuki Fumitaka Suzuki Kenji Ikeda Hiromitsu Kumada Circulating MicroRNA‐122 and Fibrosis Stage Predict Mortality of Japanese Patients With Histopathologically Confirmed NAFLD Hepatology Communications |
| title | Circulating MicroRNA‐122 and Fibrosis Stage Predict Mortality of Japanese Patients With Histopathologically Confirmed NAFLD |
| title_full | Circulating MicroRNA‐122 and Fibrosis Stage Predict Mortality of Japanese Patients With Histopathologically Confirmed NAFLD |
| title_fullStr | Circulating MicroRNA‐122 and Fibrosis Stage Predict Mortality of Japanese Patients With Histopathologically Confirmed NAFLD |
| title_full_unstemmed | Circulating MicroRNA‐122 and Fibrosis Stage Predict Mortality of Japanese Patients With Histopathologically Confirmed NAFLD |
| title_short | Circulating MicroRNA‐122 and Fibrosis Stage Predict Mortality of Japanese Patients With Histopathologically Confirmed NAFLD |
| title_sort | circulating microrna 122 and fibrosis stage predict mortality of japanese patients with histopathologically confirmed nafld |
| url | https://doi.org/10.1002/hep4.1445 |
| work_keys_str_mv | AT norioakuta circulatingmicrorna122andfibrosisstagepredictmortalityofjapanesepatientswithhistopathologicallyconfirmednafld AT yusukekawamura circulatingmicrorna122andfibrosisstagepredictmortalityofjapanesepatientswithhistopathologicallyconfirmednafld AT yasujiarase circulatingmicrorna122andfibrosisstagepredictmortalityofjapanesepatientswithhistopathologicallyconfirmednafld AT satoshisaitoh circulatingmicrorna122andfibrosisstagepredictmortalityofjapanesepatientswithhistopathologicallyconfirmednafld AT shunichirofujiyama circulatingmicrorna122andfibrosisstagepredictmortalityofjapanesepatientswithhistopathologicallyconfirmednafld AT hitomisezaki circulatingmicrorna122andfibrosisstagepredictmortalityofjapanesepatientswithhistopathologicallyconfirmednafld AT tetsuyahosaka circulatingmicrorna122andfibrosisstagepredictmortalityofjapanesepatientswithhistopathologicallyconfirmednafld AT masahirokobayashi circulatingmicrorna122andfibrosisstagepredictmortalityofjapanesepatientswithhistopathologicallyconfirmednafld AT marikokobayashi circulatingmicrorna122andfibrosisstagepredictmortalityofjapanesepatientswithhistopathologicallyconfirmednafld AT yoshiyukisuzuki circulatingmicrorna122andfibrosisstagepredictmortalityofjapanesepatientswithhistopathologicallyconfirmednafld AT fumitakasuzuki circulatingmicrorna122andfibrosisstagepredictmortalityofjapanesepatientswithhistopathologicallyconfirmednafld AT kenjiikeda circulatingmicrorna122andfibrosisstagepredictmortalityofjapanesepatientswithhistopathologicallyconfirmednafld AT hiromitsukumada circulatingmicrorna122andfibrosisstagepredictmortalityofjapanesepatientswithhistopathologicallyconfirmednafld |