Prognostic and clinicopathological implications of expression of Beclin-1 and hypoxia-inducible factor 1α in serous ovarian carcinoma: an immunohistochemical study
Serous ovarian carcinoma (SOC) is an ovarian cancer with a high fatality rate. Therefore, a lot of researchers have tried to identify novel prognostic biomarkers which might improve the patient prognosis. The aims of the study were to detect the tissue protein expression of Beclin-1 in addition to H...
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| Format: | Article |
| Language: | English |
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Termedia Publishing House
2021-05-01
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| Series: | Polish Journal of Pathology |
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| Online Access: | https://www.termedia.pl/Prognostic-and-clinicopathological-implications-of-expression-of-Beclin-1-and-hypoxia-inducible-factor-1-in-serous-ovarian-carcinoma-an-immunohistochemical-study,55,44166,1,1.html |
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| author | Mohamed Alabiad Ola Harb Doaa Mandour Rehab Hemeda Rham Z. Ahmed Ahmed El-Taher Gamal Osman Amany Shalaby Amr A.A. Alnemr Mostafa T. Abdelfattah |
| author_facet | Mohamed Alabiad Ola Harb Doaa Mandour Rehab Hemeda Rham Z. Ahmed Ahmed El-Taher Gamal Osman Amany Shalaby Amr A.A. Alnemr Mostafa T. Abdelfattah |
| author_sort | Mohamed Alabiad |
| collection | DOAJ |
| description | Serous ovarian carcinoma (SOC) is an ovarian cancer with a high fatality rate. Therefore, a lot of researchers have tried to identify novel prognostic biomarkers which might improve the patient prognosis. The aims of the study were to detect the tissue protein expression of Beclin-1 in addition to HIF-1α in SOC patients, to evaluate the relationship between their expression, the clinicopathological parameters, patients’ prognosis, and the relation to chemotherapy resistance in SOC. We evaluated the expression of Beclin-1 in addition to HIF-1α in 60 patients with SOC using immunohistochemistry, followed all patients for about 36 months, analyzed associations between both markers' expression, clinicopathological data, and patients’ prognosis. Beclin-1 expression was related to low grade (p = 0.002), early SOC stage, absence of peritoneal spread (p = 0.006), and absence of lymph nodes, and distant metastases (p = 0.004 and < 0.001 respectively), while HIF-1α expression was associated with higher grade and stage (p = 0.007), and presence of nodal and distant metastases (p < 0.001 and = 0.012 respectively). High Beclin-1 expression and low HIF-1α expression were positively associated with good response to chemotherapy (p = 0.047 and p = 0.022 respectively), a lower recurrence rate after successful therapy (p = 0.006 and < 0.001 respectively), and increased three-year recurrence-free and overall survival rates (p < 0.001). In SOC patients; Beclin-1 is a good prognostic marker, while HIF-1α is a poor prognostic marker. |
| first_indexed | 2024-12-20T01:21:48Z |
| format | Article |
| id | doaj.art-9111383ee5d849ada74558a54362d518 |
| institution | Directory Open Access Journal |
| issn | 1233-9687 2084-9869 |
| language | English |
| last_indexed | 2024-12-20T01:21:48Z |
| publishDate | 2021-05-01 |
| publisher | Termedia Publishing House |
| record_format | Article |
| series | Polish Journal of Pathology |
| spelling | doaj.art-9111383ee5d849ada74558a54362d5182022-12-21T19:58:25ZengTermedia Publishing HousePolish Journal of Pathology1233-96872084-98692021-05-01721233810.5114/pjp.2021.10644144166Prognostic and clinicopathological implications of expression of Beclin-1 and hypoxia-inducible factor 1α in serous ovarian carcinoma: an immunohistochemical studyMohamed AlabiadOla HarbDoaa MandourRehab HemedaRham Z. AhmedAhmed El-TaherGamal OsmanAmany ShalabyAmr A.A. AlnemrMostafa T. AbdelfattahSerous ovarian carcinoma (SOC) is an ovarian cancer with a high fatality rate. Therefore, a lot of researchers have tried to identify novel prognostic biomarkers which might improve the patient prognosis. The aims of the study were to detect the tissue protein expression of Beclin-1 in addition to HIF-1α in SOC patients, to evaluate the relationship between their expression, the clinicopathological parameters, patients’ prognosis, and the relation to chemotherapy resistance in SOC. We evaluated the expression of Beclin-1 in addition to HIF-1α in 60 patients with SOC using immunohistochemistry, followed all patients for about 36 months, analyzed associations between both markers' expression, clinicopathological data, and patients’ prognosis. Beclin-1 expression was related to low grade (p = 0.002), early SOC stage, absence of peritoneal spread (p = 0.006), and absence of lymph nodes, and distant metastases (p = 0.004 and < 0.001 respectively), while HIF-1α expression was associated with higher grade and stage (p = 0.007), and presence of nodal and distant metastases (p < 0.001 and = 0.012 respectively). High Beclin-1 expression and low HIF-1α expression were positively associated with good response to chemotherapy (p = 0.047 and p = 0.022 respectively), a lower recurrence rate after successful therapy (p = 0.006 and < 0.001 respectively), and increased three-year recurrence-free and overall survival rates (p < 0.001). In SOC patients; Beclin-1 is a good prognostic marker, while HIF-1α is a poor prognostic marker.https://www.termedia.pl/Prognostic-and-clinicopathological-implications-of-expression-of-Beclin-1-and-hypoxia-inducible-factor-1-in-serous-ovarian-carcinoma-an-immunohistochemical-study,55,44166,1,1.htmlserous ovarian carcinoma beclin-1 hif-1α survival immunohistochemistry. |
| spellingShingle | Mohamed Alabiad Ola Harb Doaa Mandour Rehab Hemeda Rham Z. Ahmed Ahmed El-Taher Gamal Osman Amany Shalaby Amr A.A. Alnemr Mostafa T. Abdelfattah Prognostic and clinicopathological implications of expression of Beclin-1 and hypoxia-inducible factor 1α in serous ovarian carcinoma: an immunohistochemical study Polish Journal of Pathology serous ovarian carcinoma beclin-1 hif-1α survival immunohistochemistry. |
| title | Prognostic and clinicopathological implications of expression of Beclin-1 and hypoxia-inducible factor 1α in serous ovarian carcinoma: an immunohistochemical study |
| title_full | Prognostic and clinicopathological implications of expression of Beclin-1 and hypoxia-inducible factor 1α in serous ovarian carcinoma: an immunohistochemical study |
| title_fullStr | Prognostic and clinicopathological implications of expression of Beclin-1 and hypoxia-inducible factor 1α in serous ovarian carcinoma: an immunohistochemical study |
| title_full_unstemmed | Prognostic and clinicopathological implications of expression of Beclin-1 and hypoxia-inducible factor 1α in serous ovarian carcinoma: an immunohistochemical study |
| title_short | Prognostic and clinicopathological implications of expression of Beclin-1 and hypoxia-inducible factor 1α in serous ovarian carcinoma: an immunohistochemical study |
| title_sort | prognostic and clinicopathological implications of expression of beclin 1 and hypoxia inducible factor 1α in serous ovarian carcinoma an immunohistochemical study |
| topic | serous ovarian carcinoma beclin-1 hif-1α survival immunohistochemistry. |
| url | https://www.termedia.pl/Prognostic-and-clinicopathological-implications-of-expression-of-Beclin-1-and-hypoxia-inducible-factor-1-in-serous-ovarian-carcinoma-an-immunohistochemical-study,55,44166,1,1.html |
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