Is the Ratio of Antibodies Against Oxidized LDL to Oxidized LDL an Indicator of Cardiovascular Risk in Psoriasis?
Objectives: Psoriasis is a chronic inflammatory skin disease. Chronic inflammation results in increased oxidative stress and oxidizes lipoproteins, increasing their atherogenicity. This study sought to estimate the levels of oxidized low-density lipoprotein (ox-LDL) and antibodies against oxidized L...
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| Format: | Article |
| Language: | English |
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Oman Medical Specialty Board
2016-09-01
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| Series: | Oman Medical Journal |
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| Online Access: | http://omjournal.org/articleDetails.aspx?coType=1&aId=1818 |
| _version_ | 1828484268589842432 |
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| author | Medha Rajappa Devinder Mohan Thappa Laxmisha Chandrashekar Malathi Munisamy G. Revathy |
| author_facet | Medha Rajappa Devinder Mohan Thappa Laxmisha Chandrashekar Malathi Munisamy G. Revathy |
| author_sort | Medha Rajappa |
| collection | DOAJ |
| description | Objectives: Psoriasis is a chronic inflammatory skin disease. Chronic inflammation results in increased oxidative stress and oxidizes lipoproteins, increasing their atherogenicity. This study sought to estimate the levels of oxidized low-density lipoprotein (ox-LDL) and antibodies against oxidized LDL (anti-ox-LDL) and compute the ratio of anti-ox-LDL/ox-LDL as a single composite parameter to assess the oxidative lipoprotein burden as an indicator of cardiovascular risk in patients with psoriasis. Methods: This cross-sectional study included 45 patients with psoriasis. All patients were given a psoriasis severity index score and their ox-LDL and anti-ox-LDL estimated using ELISA. Results: The results of this study show an elevation in the ratio of anti-ox-LDL to ox-LDL in patients with psoriasis, which initiate and perpetuate the pathogenesis of psoriasis and its comorbidity, atherosclerotic cardiovascular disease. Conclusions: Our results suggest that an elevated ratio of anti-ox-LDL/ox-LDL can serve as a composite parameter reflecting the total oxidative lipoprotein burden and cardiovascular risk in psoriasis patients. |
| first_indexed | 2024-12-11T08:52:57Z |
| format | Article |
| id | doaj.art-9111560ceb5b4560a80cb394ae45f3b1 |
| institution | Directory Open Access Journal |
| issn | 1999-768X 2070-5204 |
| language | English |
| last_indexed | 2024-12-11T08:52:57Z |
| publishDate | 2016-09-01 |
| publisher | Oman Medical Specialty Board |
| record_format | Article |
| series | Oman Medical Journal |
| spelling | doaj.art-9111560ceb5b4560a80cb394ae45f3b12022-12-22T01:13:58ZengOman Medical Specialty BoardOman Medical Journal1999-768X2070-52042016-09-01315390393Is the Ratio of Antibodies Against Oxidized LDL to Oxidized LDL an Indicator of Cardiovascular Risk in Psoriasis?Medha Rajappa0Devinder Mohan Thappa1Laxmisha Chandrashekar2Malathi Munisamy3G. Revathy4Department of Biochemistry, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, IndiaDepartment of Dermatology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, IndiaDepartment of Dermatology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, IndiaDepartment of Dermatology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, IndiaDepartment of Biochemistry, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, IndiaObjectives: Psoriasis is a chronic inflammatory skin disease. Chronic inflammation results in increased oxidative stress and oxidizes lipoproteins, increasing their atherogenicity. This study sought to estimate the levels of oxidized low-density lipoprotein (ox-LDL) and antibodies against oxidized LDL (anti-ox-LDL) and compute the ratio of anti-ox-LDL/ox-LDL as a single composite parameter to assess the oxidative lipoprotein burden as an indicator of cardiovascular risk in patients with psoriasis. Methods: This cross-sectional study included 45 patients with psoriasis. All patients were given a psoriasis severity index score and their ox-LDL and anti-ox-LDL estimated using ELISA. Results: The results of this study show an elevation in the ratio of anti-ox-LDL to ox-LDL in patients with psoriasis, which initiate and perpetuate the pathogenesis of psoriasis and its comorbidity, atherosclerotic cardiovascular disease. Conclusions: Our results suggest that an elevated ratio of anti-ox-LDL/ox-LDL can serve as a composite parameter reflecting the total oxidative lipoprotein burden and cardiovascular risk in psoriasis patients.http://omjournal.org/articleDetails.aspx?coType=1&aId=1818PsoriasisOxidized Low Density Lipoprotein; Oxidative Stress; Cardiovascular DiseaseOxidized Low Density LipoproteinOxidative StressCardiovascular Disease |
| spellingShingle | Medha Rajappa Devinder Mohan Thappa Laxmisha Chandrashekar Malathi Munisamy G. Revathy Is the Ratio of Antibodies Against Oxidized LDL to Oxidized LDL an Indicator of Cardiovascular Risk in Psoriasis? Oman Medical Journal Psoriasis Oxidized Low Density Lipoprotein; Oxidative Stress; Cardiovascular Disease Oxidized Low Density Lipoprotein Oxidative Stress Cardiovascular Disease |
| title | Is the Ratio of Antibodies Against Oxidized LDL to Oxidized LDL an Indicator of Cardiovascular Risk in Psoriasis? |
| title_full | Is the Ratio of Antibodies Against Oxidized LDL to Oxidized LDL an Indicator of Cardiovascular Risk in Psoriasis? |
| title_fullStr | Is the Ratio of Antibodies Against Oxidized LDL to Oxidized LDL an Indicator of Cardiovascular Risk in Psoriasis? |
| title_full_unstemmed | Is the Ratio of Antibodies Against Oxidized LDL to Oxidized LDL an Indicator of Cardiovascular Risk in Psoriasis? |
| title_short | Is the Ratio of Antibodies Against Oxidized LDL to Oxidized LDL an Indicator of Cardiovascular Risk in Psoriasis? |
| title_sort | is the ratio of antibodies against oxidized ldl to oxidized ldl an indicator of cardiovascular risk in psoriasis |
| topic | Psoriasis Oxidized Low Density Lipoprotein; Oxidative Stress; Cardiovascular Disease Oxidized Low Density Lipoprotein Oxidative Stress Cardiovascular Disease |
| url | http://omjournal.org/articleDetails.aspx?coType=1&aId=1818 |
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