Acute myeloid leukemia with CPSF6–RARG fusion resembling acute promyelocytic leukemia with extramedullary infiltration
Some subtypes of acute myeloid leukemia (AML) share morphologic, immunophenotypic, and clinical features of acute promyelocytic leukemia (APL), but lack a PML–RARA (promyelocytic leukemia–retinoic acid receptor alpha) fusion gene. Instead, they have the retinoic acid receptor beta (RARB) or retinoic...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2021-01-01
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| Series: | Therapeutic Advances in Hematology |
| Online Access: | https://doi.org/10.1177/2040620720976984 |
| _version_ | 1818725661211099136 |
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| author | Xiaoyan Han Chunxiang Jin Gaofeng Zheng Yi Li Yungui Wang Enfan Zhang Honghu Zhu Zhen Cai |
| author_facet | Xiaoyan Han Chunxiang Jin Gaofeng Zheng Yi Li Yungui Wang Enfan Zhang Honghu Zhu Zhen Cai |
| author_sort | Xiaoyan Han |
| collection | DOAJ |
| description | Some subtypes of acute myeloid leukemia (AML) share morphologic, immunophenotypic, and clinical features of acute promyelocytic leukemia (APL), but lack a PML–RARA (promyelocytic leukemia–retinoic acid receptor alpha) fusion gene. Instead, they have the retinoic acid receptor beta (RARB) or retinoic acid receptor gamma (RARG) rearranged. Almost all of these AML subtypes exhibit resistance to all-trans retinoic acid (ATRA); undoubtedly, the prognosis is poor. Here, we present an AML patient resembling APL with a novel cleavage and polyadenylation specific factor 6 ( CPSF6 ) –RARG fusion, showing resistance to ATRA and poor response to chemotherapy with homoharringtonine and cytarabine. Simultaneously, the patient also had extramedullary infiltration. |
| first_indexed | 2024-12-17T21:45:51Z |
| format | Article |
| id | doaj.art-911300e9a3454b0d887f4ad109c74513 |
| institution | Directory Open Access Journal |
| issn | 2040-6215 |
| language | English |
| last_indexed | 2024-12-17T21:45:51Z |
| publishDate | 2021-01-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Therapeutic Advances in Hematology |
| spelling | doaj.art-911300e9a3454b0d887f4ad109c745132022-12-21T21:31:28ZengSAGE PublishingTherapeutic Advances in Hematology2040-62152021-01-011210.1177/2040620720976984Acute myeloid leukemia with CPSF6–RARG fusion resembling acute promyelocytic leukemia with extramedullary infiltrationXiaoyan HanChunxiang JinGaofeng ZhengYi LiYungui WangEnfan ZhangHonghu ZhuZhen CaiSome subtypes of acute myeloid leukemia (AML) share morphologic, immunophenotypic, and clinical features of acute promyelocytic leukemia (APL), but lack a PML–RARA (promyelocytic leukemia–retinoic acid receptor alpha) fusion gene. Instead, they have the retinoic acid receptor beta (RARB) or retinoic acid receptor gamma (RARG) rearranged. Almost all of these AML subtypes exhibit resistance to all-trans retinoic acid (ATRA); undoubtedly, the prognosis is poor. Here, we present an AML patient resembling APL with a novel cleavage and polyadenylation specific factor 6 ( CPSF6 ) –RARG fusion, showing resistance to ATRA and poor response to chemotherapy with homoharringtonine and cytarabine. Simultaneously, the patient also had extramedullary infiltration.https://doi.org/10.1177/2040620720976984 |
| spellingShingle | Xiaoyan Han Chunxiang Jin Gaofeng Zheng Yi Li Yungui Wang Enfan Zhang Honghu Zhu Zhen Cai Acute myeloid leukemia with CPSF6–RARG fusion resembling acute promyelocytic leukemia with extramedullary infiltration Therapeutic Advances in Hematology |
| title | Acute myeloid leukemia with CPSF6–RARG fusion resembling acute promyelocytic leukemia with extramedullary infiltration |
| title_full | Acute myeloid leukemia with CPSF6–RARG fusion resembling acute promyelocytic leukemia with extramedullary infiltration |
| title_fullStr | Acute myeloid leukemia with CPSF6–RARG fusion resembling acute promyelocytic leukemia with extramedullary infiltration |
| title_full_unstemmed | Acute myeloid leukemia with CPSF6–RARG fusion resembling acute promyelocytic leukemia with extramedullary infiltration |
| title_short | Acute myeloid leukemia with CPSF6–RARG fusion resembling acute promyelocytic leukemia with extramedullary infiltration |
| title_sort | acute myeloid leukemia with cpsf6 rarg fusion resembling acute promyelocytic leukemia with extramedullary infiltration |
| url | https://doi.org/10.1177/2040620720976984 |
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