Evaluation of a novel hexavalent humanized anti-IGF-1R antibody and its bivalent parental IgG in diverse cancer cell lines.

Evaluation of a novel hexavalent humanized anti-IGF-1R antibody and its bivalent parental IgG in diverse cancer cell lines.

A major mechanism of monoclonal antibodies that selectively target the insulin-like growth factor type 1 receptor (IGF-1R) to inhibit tumor growth is by downregulating the receptor, regardless whether they are capable (antagonistic) or incapable (agonistic) of blocking the binding of cognate ligands...

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Bibliographic Details
Main Authors:	Chien-Hsing Chang, Yang Wang, Preeti Trisal, Rongxiu Li, Diane L Rossi, Anju Nair, Pankaj Gupta, Michele Losman, Thomas M Cardillo, Edmund A Rossi, David M Goldenberg
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2012-01-01
Series:	PLoS ONE
Online Access:	http://europepmc.org/articles/PMC3432068?pdf=render

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