Associations of dietary vitamin K and bone markers in adult Saudi females
Objective: Osteoporosis is a bone disease characterized by bone mass reduction with a prevalence of approximately 34–48% in Saudi Arabia. Many risk factors can increase osteoporosis fracture, including low vitamin K levels. However, its exact role on bone mineral density (BMD) remains under investig...
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| Format: | Article |
| Language: | English |
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Elsevier
2020-07-01
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| Series: | Journal of King Saud University: Science |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1018364720301828 |
| _version_ | 1819010845470883840 |
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| author | Samaher F. Alsadhan Sobhy M. Yakout Syed D. Hussain Dara Al-Disi Yousef M. Al-Saleh Nasser M. Al-Daghri |
| author_facet | Samaher F. Alsadhan Sobhy M. Yakout Syed D. Hussain Dara Al-Disi Yousef M. Al-Saleh Nasser M. Al-Daghri |
| author_sort | Samaher F. Alsadhan |
| collection | DOAJ |
| description | Objective: Osteoporosis is a bone disease characterized by bone mass reduction with a prevalence of approximately 34–48% in Saudi Arabia. Many risk factors can increase osteoporosis fracture, including low vitamin K levels. However, its exact role on bone mineral density (BMD) remains under investigated. This study aims to determine whether dietary vitamin K is associated with BMD, inflammation, undercarboxylated osteocalcin (ucOC) and other bone markers among adult Saudi females. Methods: A total of 138 Saudi females aged 25 and above were recruited from different primary health care centers in Riyadh, Saudi Arabia, and were divided according to BMD status (N = 53 normal; N = 85 low BMD). Each participant completed a food frequency questionnaire. Anthropometrics were measured and serum 25(OH)D and vitamin K, bone markers (ucOC and CTX) and cytokines (IL-6, TNF-α) were assessed using assays. Results: Low dietary vitamin K intakes were observed in both groups, ranging only 16–19 µg/day. A positive association was seen between dietary vitamin K and IL-6 in low BMD group and TNF-α in all participants. No significant association was seen between dietary vitamin K and BMD. Conclusion: Dietary vitamin K is significantly associated with inflammation and not BMD in adult Saudi females. The alarmingly low dietary vitamin K intake is worth investigating further. |
| first_indexed | 2024-12-21T01:18:44Z |
| format | Article |
| id | doaj.art-9113bba46d7a4ae1967c6d05a1e28e37 |
| institution | Directory Open Access Journal |
| issn | 1018-3647 |
| language | English |
| last_indexed | 2024-12-21T01:18:44Z |
| publishDate | 2020-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of King Saud University: Science |
| spelling | doaj.art-9113bba46d7a4ae1967c6d05a1e28e372022-12-21T19:20:42ZengElsevierJournal of King Saud University: Science1018-36472020-07-0132526412645Associations of dietary vitamin K and bone markers in adult Saudi femalesSamaher F. Alsadhan0Sobhy M. Yakout1Syed D. Hussain2Dara Al-Disi3Yousef M. Al-Saleh4Nasser M. Al-Daghri5Biochemistry Department, College of Science, King Saud University, Riyadh 11451, Saudi ArabiaBiochemistry Department, College of Science, King Saud University, Riyadh 11451, Saudi Arabia; Chair for Biomarkers of Chronic Diseases, College of Science, King Saud University, Riyadh 11451, Saudi ArabiaBiochemistry Department, College of Science, King Saud University, Riyadh 11451, Saudi Arabia; Chair for Biomarkers of Chronic Diseases, College of Science, King Saud University, Riyadh 11451, Saudi ArabiaDepartment of Community Health Sciences College of Applied Medical Sciences, King Saud University, Riyadh, Saudi ArabiaChair for Biomarkers of Chronic Diseases, College of Science, King Saud University, Riyadh 11451, Saudi Arabia; College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Riyadh 22490, Saudi Arabia; King Abdullah International Medical Research Center, Riyadh 11481, Saudi Arabia; Department of Medicine, King Abdulaziz Medical City, Riyadh, Ministry of National Guard-Health Affairs, Riyadh 14611, Saudi ArabiaBiochemistry Department, College of Science, King Saud University, Riyadh 11451, Saudi Arabia; Chair for Biomarkers of Chronic Diseases, College of Science, King Saud University, Riyadh 11451, Saudi Arabia; Corresponding author at: Chair for Biomarkers of Chronic Diseases Biochemistry Department College of Science, King Saud University, PO Box, 2455, Riyadh 11451, Saudi Arabia.Objective: Osteoporosis is a bone disease characterized by bone mass reduction with a prevalence of approximately 34–48% in Saudi Arabia. Many risk factors can increase osteoporosis fracture, including low vitamin K levels. However, its exact role on bone mineral density (BMD) remains under investigated. This study aims to determine whether dietary vitamin K is associated with BMD, inflammation, undercarboxylated osteocalcin (ucOC) and other bone markers among adult Saudi females. Methods: A total of 138 Saudi females aged 25 and above were recruited from different primary health care centers in Riyadh, Saudi Arabia, and were divided according to BMD status (N = 53 normal; N = 85 low BMD). Each participant completed a food frequency questionnaire. Anthropometrics were measured and serum 25(OH)D and vitamin K, bone markers (ucOC and CTX) and cytokines (IL-6, TNF-α) were assessed using assays. Results: Low dietary vitamin K intakes were observed in both groups, ranging only 16–19 µg/day. A positive association was seen between dietary vitamin K and IL-6 in low BMD group and TNF-α in all participants. No significant association was seen between dietary vitamin K and BMD. Conclusion: Dietary vitamin K is significantly associated with inflammation and not BMD in adult Saudi females. The alarmingly low dietary vitamin K intake is worth investigating further.http://www.sciencedirect.com/science/article/pii/S1018364720301828Vitamin KBone markersUndercarboxylated osteocalcinBMD |
| spellingShingle | Samaher F. Alsadhan Sobhy M. Yakout Syed D. Hussain Dara Al-Disi Yousef M. Al-Saleh Nasser M. Al-Daghri Associations of dietary vitamin K and bone markers in adult Saudi females Journal of King Saud University: Science Vitamin K Bone markers Undercarboxylated osteocalcin BMD |
| title | Associations of dietary vitamin K and bone markers in adult Saudi females |
| title_full | Associations of dietary vitamin K and bone markers in adult Saudi females |
| title_fullStr | Associations of dietary vitamin K and bone markers in adult Saudi females |
| title_full_unstemmed | Associations of dietary vitamin K and bone markers in adult Saudi females |
| title_short | Associations of dietary vitamin K and bone markers in adult Saudi females |
| title_sort | associations of dietary vitamin k and bone markers in adult saudi females |
| topic | Vitamin K Bone markers Undercarboxylated osteocalcin BMD |
| url | http://www.sciencedirect.com/science/article/pii/S1018364720301828 |
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