Causal Effect of Chondroitin, Glucosamine, Vitamin, and Mineral Intake on Kidney Function: A Mendelian Randomization Study
The causal effects of chondroitin, glucosamine, and vitamin/mineral supplement intake on kidney function remain unknown, despite being commonly used. We conducted a two-sample summary-level Mendelian randomization (MR) analysis to test for causal associations between regular dietary supplement intak...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-07-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/15/15/3318 |
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| author | Jeong-Min Cho Jung-Hun Koh Seong-Geun Kim Soojin Lee Yaerim Kim Semin Cho Kwangsoo Kim Yong-Chul Kim Seung-Seok Han Hajeong Lee Jung-Pyo Lee Kwon-Wook Joo Chun-Soo Lim Yon-Su Kim Dong-Ki Kim Sehoon Park |
| author_facet | Jeong-Min Cho Jung-Hun Koh Seong-Geun Kim Soojin Lee Yaerim Kim Semin Cho Kwangsoo Kim Yong-Chul Kim Seung-Seok Han Hajeong Lee Jung-Pyo Lee Kwon-Wook Joo Chun-Soo Lim Yon-Su Kim Dong-Ki Kim Sehoon Park |
| author_sort | Jeong-Min Cho |
| collection | DOAJ |
| description | The causal effects of chondroitin, glucosamine, and vitamin/mineral supplement intake on kidney function remain unknown, despite being commonly used. We conducted a two-sample summary-level Mendelian randomization (MR) analysis to test for causal associations between regular dietary supplement intake and kidney function. Genetic instruments for chondroitin, glucosamine, and vitamin/mineral supplement intake were obtained from a genome-wide association study of European ancestry. Summary statistics for the log-transformed estimated glomerular filtration rate (log-eGFR) were provided by the CKDGen consortium. The multiplicative random-effects inverse-variance weighted method showed that genetically predicted chondroitin and glucosamine intake was causally associated with a lower eGFR (chondroitin, eGFR change beta = −0.113%, standard error (SE) = 0.03%, <i>p</i>-value = 2 × 10<sup>−4</sup>; glucosamine, eGFR change beta = −0.240%, SE = 0.035%, <i>p</i>-value = 6 × 10<sup>−12</sup>). However, a genetically predicted vitamin/mineral supplement intake was associated with a higher eGFR (eGFR change beta = 1.426%, SE = 0.136%, <i>p</i>-value = 1 × 10<sup>−25</sup>). Validation analyses and pleiotropy-robust MR results for chondroitin and vitamin/mineral supplement intake supported the main results. Our MR study suggests a potential causal effect of chondroitin and glucosamine intake on kidney function. Therefore, clinicians should carefully monitor their long-term effects. |
| first_indexed | 2024-03-11T00:19:40Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-11T00:19:40Z |
| publishDate | 2023-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-91146483e4cf483ba197df9a993034802023-11-18T23:22:55ZengMDPI AGNutrients2072-66432023-07-011515331810.3390/nu15153318Causal Effect of Chondroitin, Glucosamine, Vitamin, and Mineral Intake on Kidney Function: A Mendelian Randomization StudyJeong-Min Cho0Jung-Hun Koh1Seong-Geun Kim2Soojin Lee3Yaerim Kim4Semin Cho5Kwangsoo Kim6Yong-Chul Kim7Seung-Seok Han8Hajeong Lee9Jung-Pyo Lee10Kwon-Wook Joo11Chun-Soo Lim12Yon-Su Kim13Dong-Ki Kim14Sehoon Park15Department of Internal Medicine, Seoul National University Hospital, Seoul 03080, Republic of KoreaDepartment of Internal Medicine, Seoul National University Hospital, Seoul 03080, Republic of KoreaDepartment of Internal Medicine, Inje University Sanggye Paik Hospital, Seoul 01757, Republic of KoreaDepartment of Internal Medicine, Uijeongbu Eulji University Medical Center, Uijeongbu 11759, Republic of KoreaDepartment of Internal Medicine, Keimyung University School of Medicine, Daegu 42601, Republic of KoreaDepartment of Internal Medicine, Chung-Ang University Gwangmyeong Hospital, Gwangmyeong 14353, Republic of KoreaTransdisciplinary Department of Medicine & Advanced Technology, Seoul National University Hospital, Seoul 03080, Republic of KoreaDepartment of Internal Medicine, Seoul National University Hospital, Seoul 03080, Republic of KoreaDepartment of Internal Medicine, Seoul National University Hospital, Seoul 03080, Republic of KoreaDepartment of Internal Medicine, Seoul National University Hospital, Seoul 03080, Republic of KoreaDepartment of Internal Medicine, Seoul National University College of Medicine, Seoul 07061, Republic of KoreaDepartment of Internal Medicine, Seoul National University Hospital, Seoul 03080, Republic of KoreaDepartment of Internal Medicine, Seoul National University College of Medicine, Seoul 07061, Republic of KoreaDepartment of Internal Medicine, Seoul National University Hospital, Seoul 03080, Republic of KoreaDepartment of Internal Medicine, Seoul National University Hospital, Seoul 03080, Republic of KoreaDepartment of Internal Medicine, Seoul National University Hospital, Seoul 03080, Republic of KoreaThe causal effects of chondroitin, glucosamine, and vitamin/mineral supplement intake on kidney function remain unknown, despite being commonly used. We conducted a two-sample summary-level Mendelian randomization (MR) analysis to test for causal associations between regular dietary supplement intake and kidney function. Genetic instruments for chondroitin, glucosamine, and vitamin/mineral supplement intake were obtained from a genome-wide association study of European ancestry. Summary statistics for the log-transformed estimated glomerular filtration rate (log-eGFR) were provided by the CKDGen consortium. The multiplicative random-effects inverse-variance weighted method showed that genetically predicted chondroitin and glucosamine intake was causally associated with a lower eGFR (chondroitin, eGFR change beta = −0.113%, standard error (SE) = 0.03%, <i>p</i>-value = 2 × 10<sup>−4</sup>; glucosamine, eGFR change beta = −0.240%, SE = 0.035%, <i>p</i>-value = 6 × 10<sup>−12</sup>). However, a genetically predicted vitamin/mineral supplement intake was associated with a higher eGFR (eGFR change beta = 1.426%, SE = 0.136%, <i>p</i>-value = 1 × 10<sup>−25</sup>). Validation analyses and pleiotropy-robust MR results for chondroitin and vitamin/mineral supplement intake supported the main results. Our MR study suggests a potential causal effect of chondroitin and glucosamine intake on kidney function. Therefore, clinicians should carefully monitor their long-term effects.https://www.mdpi.com/2072-6643/15/15/3318chondroitinglucosaminevitaminsmineralsglomerular filtration rate |
| spellingShingle | Jeong-Min Cho Jung-Hun Koh Seong-Geun Kim Soojin Lee Yaerim Kim Semin Cho Kwangsoo Kim Yong-Chul Kim Seung-Seok Han Hajeong Lee Jung-Pyo Lee Kwon-Wook Joo Chun-Soo Lim Yon-Su Kim Dong-Ki Kim Sehoon Park Causal Effect of Chondroitin, Glucosamine, Vitamin, and Mineral Intake on Kidney Function: A Mendelian Randomization Study Nutrients chondroitin glucosamine vitamins minerals glomerular filtration rate |
| title | Causal Effect of Chondroitin, Glucosamine, Vitamin, and Mineral Intake on Kidney Function: A Mendelian Randomization Study |
| title_full | Causal Effect of Chondroitin, Glucosamine, Vitamin, and Mineral Intake on Kidney Function: A Mendelian Randomization Study |
| title_fullStr | Causal Effect of Chondroitin, Glucosamine, Vitamin, and Mineral Intake on Kidney Function: A Mendelian Randomization Study |
| title_full_unstemmed | Causal Effect of Chondroitin, Glucosamine, Vitamin, and Mineral Intake on Kidney Function: A Mendelian Randomization Study |
| title_short | Causal Effect of Chondroitin, Glucosamine, Vitamin, and Mineral Intake on Kidney Function: A Mendelian Randomization Study |
| title_sort | causal effect of chondroitin glucosamine vitamin and mineral intake on kidney function a mendelian randomization study |
| topic | chondroitin glucosamine vitamins minerals glomerular filtration rate |
| url | https://www.mdpi.com/2072-6643/15/15/3318 |
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