Mechanistic insights into the detection of free fatty and bile acids by ileal glucagon-like peptide-1 secreting cells

Mechanistic insights into the detection of free fatty and bile acids by ileal glucagon-like peptide-1 secreting cells

Objectives: The aim of this study was to investigate the electrical properties of ileal Glucagon-like peptide 1 (GLP-1) secreting L-cells using murine organoid cultures and the electrophysiological and intracellular signaling pathways recruited following activation of the Gαq-coupled free fatty acid...

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Bibliographic Details
Main Authors:	Deborah A. Goldspink, Van B. Lu, Lawrence J. Billing, Pierre Larraufie, Gwen Tolhurst, Fiona M. Gribble, Frank Reimann
Format:	Article
Language:	English
Published:	Elsevier 2018-01-01
Series:	Molecular Metabolism
Online Access:	http://www.sciencedirect.com/science/article/pii/S2212877817307500

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