Secretory quality control constrains functional selection-associated protein structure innovation

The mismatch in the conserved structure but different expression levels of C-reactive protein (CRP) in distinct species is reconciled by functional selection on hidden activities of unfolded CRPs.

Bibliographic Details
Main Authors: Bin Cheng, Jian-Min Lv, Yu-Lin Liang, Li Zhu, Xiao-Ping Huang, Hai-Yun Li, Lawrence A. Potempa, Shang-Rong Ji, Yi Wu
Format: Article
Language:English
Published: Nature Portfolio 2022-03-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-022-03220-3