Surface Roughness and Biocompatibility of Polycaprolactone Bone Scaffolds: An Energy-Density-Guided Parameter Optimization for Selective Laser Sintering
Three-dimensional porous polycaprolactone (PCL) bone scaffolds prepared by selective laser sintering (SLS) have demonstrated great potential in the repair of non-load-bearing bone defects. The microgeometry and surface roughness of PCL scaffolds during the SLS process may change the biocompatibility...
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| Format: | Article |
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Frontiers Media S.A.
2022-07-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2022.888267/full |
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| author | Jian Han Jian Han Zehua Li Zehua Li Yuxuan Sun Fajun Cheng Fajun Cheng Lei Zhu Yaoyao Zhang Yaoyao Zhang Zirui Zhang Jinzhe Wu Junfeng Wang Junfeng Wang Junfeng Wang Junfeng Wang |
| author_facet | Jian Han Jian Han Zehua Li Zehua Li Yuxuan Sun Fajun Cheng Fajun Cheng Lei Zhu Yaoyao Zhang Yaoyao Zhang Zirui Zhang Jinzhe Wu Junfeng Wang Junfeng Wang Junfeng Wang Junfeng Wang |
| author_sort | Jian Han |
| collection | DOAJ |
| description | Three-dimensional porous polycaprolactone (PCL) bone scaffolds prepared by selective laser sintering (SLS) have demonstrated great potential in the repair of non-load-bearing bone defects. The microgeometry and surface roughness of PCL scaffolds during the SLS process may change the biocompatibility and bioactivity of the scaffolds. However, in addition to the widely concerned mechanical properties and structural accuracy of scaffolds, there is still a lack of systematic research on how SLS process parameters affect the surface roughness of PCL scaffolds and the relationship between roughness and biocompatibility of scaffolds. In this study, we use the energy density model (EDM) combined with the thermodynamic properties of PCL powder to calculate the energy density range (Ed1–Ed3) suitable for PCL sintering. Five PCL scaffolds with different laser powers and scanning speeds were prepared; their dimensional accuracy, mechanical strength, and surface properties were comprehensively evaluated, and the bioactivities were compared through the attachment and proliferation of MC3T3-E1 cells on the scaffolds. It was found that the high energy density (Ed3) reduced the shape fidelity related to pore size and porosity, and the dense and smooth surface of the scaffolds showed poor cytocompatibility, while the low energy density (Ed1) resulted in weak mechanical properties, but the rough surface caused by incomplete sintered PCL particles facilitated the cell adhesion and proliferation. Therefore, the surface roughness and related biocompatibility of PCL bone scaffolds should be considered in energy-density-guided SLS parameter optimization. |
| first_indexed | 2024-04-12T07:22:53Z |
| format | Article |
| id | doaj.art-9115ae1e0bd24256a105e96d90c2fc56 |
| institution | Directory Open Access Journal |
| issn | 2296-4185 |
| language | English |
| last_indexed | 2024-04-12T07:22:53Z |
| publishDate | 2022-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj.art-9115ae1e0bd24256a105e96d90c2fc562022-12-22T03:42:16ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852022-07-011010.3389/fbioe.2022.888267888267Surface Roughness and Biocompatibility of Polycaprolactone Bone Scaffolds: An Energy-Density-Guided Parameter Optimization for Selective Laser SinteringJian Han0Jian Han1Zehua Li2Zehua Li3Yuxuan Sun4Fajun Cheng5Fajun Cheng6Lei Zhu7Yaoyao Zhang8Yaoyao Zhang9Zirui Zhang10Jinzhe Wu11Junfeng Wang12Junfeng Wang13Junfeng Wang14Junfeng Wang15High Magnetic Field Laboratory, CAS Key Laboratory of High Magnetic Field and Ion Beam Physical Biology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, ChinaUniversity of Science and Technology of China, Hefei, ChinaHigh Magnetic Field Laboratory, CAS Key Laboratory of High Magnetic Field and Ion Beam Physical Biology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, ChinaUniversity of Science and Technology of China, Hefei, ChinaUniversity of Science and Technology of China, Hefei, ChinaHigh Magnetic Field Laboratory, CAS Key Laboratory of High Magnetic Field and Ion Beam Physical Biology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, ChinaSchool of Basic Medical Sciences, Anhui Medical University, Hefei, ChinaHigh Magnetic Field Laboratory, CAS Key Laboratory of High Magnetic Field and Ion Beam Physical Biology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, ChinaHigh Magnetic Field Laboratory, CAS Key Laboratory of High Magnetic Field and Ion Beam Physical Biology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, ChinaUniversity of Science and Technology of China, Hefei, ChinaSchool of Electronic Engineering and Intelligent Manufacturing, Anqing Normal University, Anqing, ChinaSchool of Electronic Engineering, Naval University of Engineering, Wuhan, ChinaHigh Magnetic Field Laboratory, CAS Key Laboratory of High Magnetic Field and Ion Beam Physical Biology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, ChinaUniversity of Science and Technology of China, Hefei, ChinaSchool of Basic Medical Sciences, Anhui Medical University, Hefei, ChinaInstitutes of Physical Science and Information Technology, Anhui University, Hefei, ChinaThree-dimensional porous polycaprolactone (PCL) bone scaffolds prepared by selective laser sintering (SLS) have demonstrated great potential in the repair of non-load-bearing bone defects. The microgeometry and surface roughness of PCL scaffolds during the SLS process may change the biocompatibility and bioactivity of the scaffolds. However, in addition to the widely concerned mechanical properties and structural accuracy of scaffolds, there is still a lack of systematic research on how SLS process parameters affect the surface roughness of PCL scaffolds and the relationship between roughness and biocompatibility of scaffolds. In this study, we use the energy density model (EDM) combined with the thermodynamic properties of PCL powder to calculate the energy density range (Ed1–Ed3) suitable for PCL sintering. Five PCL scaffolds with different laser powers and scanning speeds were prepared; their dimensional accuracy, mechanical strength, and surface properties were comprehensively evaluated, and the bioactivities were compared through the attachment and proliferation of MC3T3-E1 cells on the scaffolds. It was found that the high energy density (Ed3) reduced the shape fidelity related to pore size and porosity, and the dense and smooth surface of the scaffolds showed poor cytocompatibility, while the low energy density (Ed1) resulted in weak mechanical properties, but the rough surface caused by incomplete sintered PCL particles facilitated the cell adhesion and proliferation. Therefore, the surface roughness and related biocompatibility of PCL bone scaffolds should be considered in energy-density-guided SLS parameter optimization.https://www.frontiersin.org/articles/10.3389/fbioe.2022.888267/fullselective laser sinteringsurface roughnessbiocompatibilityenergy density modelpolycaprolactone |
| spellingShingle | Jian Han Jian Han Zehua Li Zehua Li Yuxuan Sun Fajun Cheng Fajun Cheng Lei Zhu Yaoyao Zhang Yaoyao Zhang Zirui Zhang Jinzhe Wu Junfeng Wang Junfeng Wang Junfeng Wang Junfeng Wang Surface Roughness and Biocompatibility of Polycaprolactone Bone Scaffolds: An Energy-Density-Guided Parameter Optimization for Selective Laser Sintering Frontiers in Bioengineering and Biotechnology selective laser sintering surface roughness biocompatibility energy density model polycaprolactone |
| title | Surface Roughness and Biocompatibility of Polycaprolactone Bone Scaffolds: An Energy-Density-Guided Parameter Optimization for Selective Laser Sintering |
| title_full | Surface Roughness and Biocompatibility of Polycaprolactone Bone Scaffolds: An Energy-Density-Guided Parameter Optimization for Selective Laser Sintering |
| title_fullStr | Surface Roughness and Biocompatibility of Polycaprolactone Bone Scaffolds: An Energy-Density-Guided Parameter Optimization for Selective Laser Sintering |
| title_full_unstemmed | Surface Roughness and Biocompatibility of Polycaprolactone Bone Scaffolds: An Energy-Density-Guided Parameter Optimization for Selective Laser Sintering |
| title_short | Surface Roughness and Biocompatibility of Polycaprolactone Bone Scaffolds: An Energy-Density-Guided Parameter Optimization for Selective Laser Sintering |
| title_sort | surface roughness and biocompatibility of polycaprolactone bone scaffolds an energy density guided parameter optimization for selective laser sintering |
| topic | selective laser sintering surface roughness biocompatibility energy density model polycaprolactone |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2022.888267/full |
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