Post-mortem brain pathology is related to declining respiratory function in community-dwelling older adults
Damage to brain structures which constitute the distributed neural network that integrates respiratory muscle and pulmonary functions, can impair adequate ventilation and its volitional control. We tested the hypothesis that the level of brain pathology in older adults is associated with declining r...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2015-10-01
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| Series: | Frontiers in Aging Neuroscience |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnagi.2015.00197/full |
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| author | Aron S. Buchman Aron S. Buchman Lei eYu Lei eYu Robert S. Wison Robert S. Wison Robert eDawe Veronique eVanderHorst Veronique eVanderHorst Julie A. Schneider Julie A. Schneider Julie A. Schneider David A. Bennett David A. Bennett |
| author_facet | Aron S. Buchman Aron S. Buchman Lei eYu Lei eYu Robert S. Wison Robert S. Wison Robert eDawe Veronique eVanderHorst Veronique eVanderHorst Julie A. Schneider Julie A. Schneider Julie A. Schneider David A. Bennett David A. Bennett |
| author_sort | Aron S. Buchman |
| collection | DOAJ |
| description | Damage to brain structures which constitute the distributed neural network that integrates respiratory muscle and pulmonary functions, can impair adequate ventilation and its volitional control. We tested the hypothesis that the level of brain pathology in older adults is associated with declining respiratory function measured during life.1,409 older adults had annual testing with spirometry and respiratory muscle strength based on maximal inspiratory and maximal expiratory pressures. Those who died underwent structured brain autopsy. On average, during 5 years of follow-up, spirometry and respiratory muscle strength showed progressive decline which was moderately correlated (ρ=0.57, p<0.001). Among decedents (N=447), indices of brain neuropathologies showed differential associations with declining spirometry and respiratory muscle strength. Nigral neuronal loss was associated with the person-specific decline in spirometry (Estimate, -0.016 unit/year, S.E. 0.006, p=0.009) and reduction of the slope variance was equal to 4%. By contrast, Alzheimer’s disease (AD) pathology (Estimate, -0.030 unit/year, S.E. 0.009, p<0.001) and macroscopic infarcts (-0.033 unit/year, S.E., 0.011, p=0.003) were associated with the person-specific decline in respiratory muscle strength and reduction of the slope variance was equal to 7%. These results suggest that brain pathology is associated with the rate of declining respiratory function in older adults. |
| first_indexed | 2024-12-23T06:43:22Z |
| format | Article |
| id | doaj.art-911650a0ed124a5a8cf7366cdb1b8bc7 |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-12-23T06:43:22Z |
| publishDate | 2015-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-911650a0ed124a5a8cf7366cdb1b8bc72022-12-21T17:56:39ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652015-10-01710.3389/fnagi.2015.00197147465Post-mortem brain pathology is related to declining respiratory function in community-dwelling older adultsAron S. Buchman0Aron S. Buchman1Lei eYu2Lei eYu3Robert S. Wison4Robert S. Wison5Robert eDawe6Veronique eVanderHorst7Veronique eVanderHorst8Julie A. Schneider9Julie A. Schneider10Julie A. Schneider11David A. Bennett12David A. Bennett13Rush University Medical CenterRush University Medical CenterRush University Medical CenterRush University Medical CenterRush University Medical CenterRush University Medical CenterRush University Medical CenterBeth Israel Deaconess Medical CenterHarvard Medical SchoolRush University Medical CenterRush University Medical CenterRush University Medical CenterRush University Medical CenterRush University Medical CenterDamage to brain structures which constitute the distributed neural network that integrates respiratory muscle and pulmonary functions, can impair adequate ventilation and its volitional control. We tested the hypothesis that the level of brain pathology in older adults is associated with declining respiratory function measured during life.1,409 older adults had annual testing with spirometry and respiratory muscle strength based on maximal inspiratory and maximal expiratory pressures. Those who died underwent structured brain autopsy. On average, during 5 years of follow-up, spirometry and respiratory muscle strength showed progressive decline which was moderately correlated (ρ=0.57, p<0.001). Among decedents (N=447), indices of brain neuropathologies showed differential associations with declining spirometry and respiratory muscle strength. Nigral neuronal loss was associated with the person-specific decline in spirometry (Estimate, -0.016 unit/year, S.E. 0.006, p=0.009) and reduction of the slope variance was equal to 4%. By contrast, Alzheimer’s disease (AD) pathology (Estimate, -0.030 unit/year, S.E. 0.009, p<0.001) and macroscopic infarcts (-0.033 unit/year, S.E., 0.011, p=0.003) were associated with the person-specific decline in respiratory muscle strength and reduction of the slope variance was equal to 7%. These results suggest that brain pathology is associated with the rate of declining respiratory function in older adults.http://journal.frontiersin.org/Journal/10.3389/fnagi.2015.00197/fullAgingAlzheimer DiseaseLewy Body DiseaseRespiration DisordersRespiratory MusclesSpirometry |
| spellingShingle | Aron S. Buchman Aron S. Buchman Lei eYu Lei eYu Robert S. Wison Robert S. Wison Robert eDawe Veronique eVanderHorst Veronique eVanderHorst Julie A. Schneider Julie A. Schneider Julie A. Schneider David A. Bennett David A. Bennett Post-mortem brain pathology is related to declining respiratory function in community-dwelling older adults Frontiers in Aging Neuroscience Aging Alzheimer Disease Lewy Body Disease Respiration Disorders Respiratory Muscles Spirometry |
| title | Post-mortem brain pathology is related to declining respiratory function in community-dwelling older adults |
| title_full | Post-mortem brain pathology is related to declining respiratory function in community-dwelling older adults |
| title_fullStr | Post-mortem brain pathology is related to declining respiratory function in community-dwelling older adults |
| title_full_unstemmed | Post-mortem brain pathology is related to declining respiratory function in community-dwelling older adults |
| title_short | Post-mortem brain pathology is related to declining respiratory function in community-dwelling older adults |
| title_sort | post mortem brain pathology is related to declining respiratory function in community dwelling older adults |
| topic | Aging Alzheimer Disease Lewy Body Disease Respiration Disorders Respiratory Muscles Spirometry |
| url | http://journal.frontiersin.org/Journal/10.3389/fnagi.2015.00197/full |
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