Ultrastructural changes in murine liver following HSV infection and stroke
The study of herpetic infection is a topical problem. Although the peculiarities and consequences of acute HSV-I infection in the brain are quite well-studied, little is known about the damage to other organs which are not a source of latent HSV-I infection, the liver in particular. The current stud...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Sciendo
2018-03-01
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| Series: | Current Issues in Pharmacy and Medical Sciences |
| Subjects: | |
| Online Access: | http://www.degruyter.com/view/j/cipms.2018.31.issue-1/cipms-2018-0002/cipms-2018-0002.xml?format=INT |
| _version_ | 1818693504756350976 |
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| author | Motorna Natalia Rybalko Svetlana Kvitnitskaya-Ryzhova Tatyana Starosyla Daria Strokina Iryna Kaminsky Rostyslav Savosko Sergey Sokurenko Liudmyla Chaikovsky Yuri |
| author_facet | Motorna Natalia Rybalko Svetlana Kvitnitskaya-Ryzhova Tatyana Starosyla Daria Strokina Iryna Kaminsky Rostyslav Savosko Sergey Sokurenko Liudmyla Chaikovsky Yuri |
| author_sort | Motorna Natalia |
| collection | DOAJ |
| description | The study of herpetic infection is a topical problem. Although the peculiarities and consequences of acute HSV-I infection in the brain are quite well-studied, little is known about the damage to other organs which are not a source of latent HSV-I infection, the liver in particular. The current study is aimed at determining the ultrastructural changes in murine liver following HSV infection and stroke. Liver samples obtained from four groups of animals were studied: 1) intact mice; 2) mice with stroke; 3) mice infected with HSV-I; 4) mice aflicted with HSV-I and subsequently simulated stroke. The study showed the reproduction of the virus in hepatic endotheliocytes, although no virions were detected in the hepatocytes. Therefore, the described changes were considered the consequences of the infectious process. Pathological changes of hepatocytes consisted of deformation and fragmentation of the nuclei, as well as accumulation of osmiophilic granules, lysosomes and lamellary bodies. Latent HSV-I infection may reactivate in liver after the stroke, potentially causing the complications of the underlying disease. |
| first_indexed | 2024-12-17T13:14:44Z |
| format | Article |
| id | doaj.art-91165999614344f9a95125394b0fd5a6 |
| institution | Directory Open Access Journal |
| issn | 2084-980X 2300-6676 |
| language | English |
| last_indexed | 2024-12-17T13:14:44Z |
| publishDate | 2018-03-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Current Issues in Pharmacy and Medical Sciences |
| spelling | doaj.art-91165999614344f9a95125394b0fd5a62022-12-21T21:47:02ZengSciendoCurrent Issues in Pharmacy and Medical Sciences2084-980X2300-66762018-03-01311101210.1515/cipms-2018-0002cipms-2018-0002Ultrastructural changes in murine liver following HSV infection and strokeMotorna Natalia0Rybalko Svetlana1Kvitnitskaya-Ryzhova Tatyana2Starosyla Daria3Strokina Iryna4Kaminsky Rostyslav5Savosko Sergey6Sokurenko Liudmyla7Chaikovsky Yuri8O.O. Bogomolets National Medical University, Department of Histology and Embryology, T. Shevchenko Blvd 13, 01601Kyiv, UkraineGromashevsky L.V. Institute of Epidemiology and Infection Diseases of NAMS of Ukraine, Kyiv, UkraineState Institution “D.F. Chebotarev Institute of Gerontology” of NAMS of Ukraine, Kyiv, UkraineGromashevsky L.V. Institute of Epidemiology and Infection Diseases of NAMS of Ukraine, Kyiv, UkraineO.O. Bogomolets National Medical University, Department of Histology and Embryology, T. Shevchenko Blvd 13, 01601Kyiv, UkraineO.O. Bogomolets National Medical University, Department of Histology and Embryology, T. Shevchenko Blvd 13, 01601Kyiv, UkraineO.O. Bogomolets National Medical University, Department of Histology and Embryology, T. Shevchenko Blvd 13, 01601Kyiv, UkraineO.O. Bogomolets National Medical University, Department of Histology and Embryology, T. Shevchenko Blvd 13, 01601Kyiv, UkraineO.O. Bogomolets National Medical University, Department of Histology and Embryology, T. Shevchenko Blvd 13, 01601Kyiv, UkraineThe study of herpetic infection is a topical problem. Although the peculiarities and consequences of acute HSV-I infection in the brain are quite well-studied, little is known about the damage to other organs which are not a source of latent HSV-I infection, the liver in particular. The current study is aimed at determining the ultrastructural changes in murine liver following HSV infection and stroke. Liver samples obtained from four groups of animals were studied: 1) intact mice; 2) mice with stroke; 3) mice infected with HSV-I; 4) mice aflicted with HSV-I and subsequently simulated stroke. The study showed the reproduction of the virus in hepatic endotheliocytes, although no virions were detected in the hepatocytes. Therefore, the described changes were considered the consequences of the infectious process. Pathological changes of hepatocytes consisted of deformation and fragmentation of the nuclei, as well as accumulation of osmiophilic granules, lysosomes and lamellary bodies. Latent HSV-I infection may reactivate in liver after the stroke, potentially causing the complications of the underlying disease.http://www.degruyter.com/view/j/cipms.2018.31.issue-1/cipms-2018-0002/cipms-2018-0002.xml?format=INTliverultrastructureherpes simplex virus type Istroke |
| spellingShingle | Motorna Natalia Rybalko Svetlana Kvitnitskaya-Ryzhova Tatyana Starosyla Daria Strokina Iryna Kaminsky Rostyslav Savosko Sergey Sokurenko Liudmyla Chaikovsky Yuri Ultrastructural changes in murine liver following HSV infection and stroke Current Issues in Pharmacy and Medical Sciences liver ultrastructure herpes simplex virus type I stroke |
| title | Ultrastructural changes in murine liver following HSV infection and stroke |
| title_full | Ultrastructural changes in murine liver following HSV infection and stroke |
| title_fullStr | Ultrastructural changes in murine liver following HSV infection and stroke |
| title_full_unstemmed | Ultrastructural changes in murine liver following HSV infection and stroke |
| title_short | Ultrastructural changes in murine liver following HSV infection and stroke |
| title_sort | ultrastructural changes in murine liver following hsv infection and stroke |
| topic | liver ultrastructure herpes simplex virus type I stroke |
| url | http://www.degruyter.com/view/j/cipms.2018.31.issue-1/cipms-2018-0002/cipms-2018-0002.xml?format=INT |
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