Central nervous system commitment in Chagas disease
The involvement of the central nervous system (CNS) during human acute and chronic Chagas disease (CD) has been largely reported. Meningoencephalitis is a frequent finding during the acute infection, while during chronic phase the CNS involvement is often accompanied by behavioral and cognitive impa...
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Format: | Article |
Language: | English |
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Frontiers Media S.A.
2022-11-01
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Series: | Frontiers in Immunology |
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Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.975106/full |
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author | Yerly Useche Ana Rosa Pérez Ana Rosa Pérez Juliana de Meis Juliana de Meis Juliana de Meis Adriana Bonomo Adriana Bonomo Adriana Bonomo Wilson Savino Wilson Savino Wilson Savino |
author_facet | Yerly Useche Ana Rosa Pérez Ana Rosa Pérez Juliana de Meis Juliana de Meis Juliana de Meis Adriana Bonomo Adriana Bonomo Adriana Bonomo Wilson Savino Wilson Savino Wilson Savino |
author_sort | Yerly Useche |
collection | DOAJ |
description | The involvement of the central nervous system (CNS) during human acute and chronic Chagas disease (CD) has been largely reported. Meningoencephalitis is a frequent finding during the acute infection, while during chronic phase the CNS involvement is often accompanied by behavioral and cognitive impairments. In the same vein, several studies have shown that rodents infected with Trypanosoma cruzi (T. cruzi) display behavior abnormalities, accompanied by brain inflammation, in situ production of pro-inflammatory cytokines and parasitism in diverse cerebral areas, with involvement of microglia, macrophages, astrocytes, and neurons. However, the mechanisms used by the parasite to reach the brain remain now largely unknown. Herein we discuss the evidence unravelling the CNS involvement and complexity of neuroimmune interactions that take place in acute and chronic CD. Also, we provide some clues to hypothesize brain infections routes in human and experimental acute CD following oral infection by T. cruzi, an infection route that became a major CD related public health issue in Brazil. |
first_indexed | 2024-04-12T10:41:36Z |
format | Article |
id | doaj.art-9116b1704d4a4ce8b8f34a2b12ea1b36 |
institution | Directory Open Access Journal |
issn | 1664-3224 |
language | English |
last_indexed | 2024-04-12T10:41:36Z |
publishDate | 2022-11-01 |
publisher | Frontiers Media S.A. |
record_format | Article |
series | Frontiers in Immunology |
spelling | doaj.art-9116b1704d4a4ce8b8f34a2b12ea1b362022-12-22T03:36:35ZengFrontiers Media S.A.Frontiers in Immunology1664-32242022-11-011310.3389/fimmu.2022.975106975106Central nervous system commitment in Chagas diseaseYerly Useche0Ana Rosa Pérez1Ana Rosa Pérez2Juliana de Meis3Juliana de Meis4Juliana de Meis5Adriana Bonomo6Adriana Bonomo7Adriana Bonomo8Wilson Savino9Wilson Savino10Wilson Savino11Laboratory on Thymus Research, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, BrazilInstitute of Clinical and Experimental Immunology of Rosario (IDICER CONICET UNR), Rosario, ArgentinaCenter for Research and Production of Biological Reagents (CIPReB), Faculty of Medical Sciences National University of Rosario, Rosario, ArgentinaLaboratory on Thymus Research, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, BrazilNational Institute of Science and Technology on Neuroimmunomodulation, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, BrazilRio de Janeiro Research Network on Neuroinflammation, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, BrazilLaboratory on Thymus Research, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, BrazilNational Institute of Science and Technology on Neuroimmunomodulation, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, BrazilRio de Janeiro Research Network on Neuroinflammation, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, BrazilLaboratory on Thymus Research, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, BrazilNational Institute of Science and Technology on Neuroimmunomodulation, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, BrazilRio de Janeiro Research Network on Neuroinflammation, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, BrazilThe involvement of the central nervous system (CNS) during human acute and chronic Chagas disease (CD) has been largely reported. Meningoencephalitis is a frequent finding during the acute infection, while during chronic phase the CNS involvement is often accompanied by behavioral and cognitive impairments. In the same vein, several studies have shown that rodents infected with Trypanosoma cruzi (T. cruzi) display behavior abnormalities, accompanied by brain inflammation, in situ production of pro-inflammatory cytokines and parasitism in diverse cerebral areas, with involvement of microglia, macrophages, astrocytes, and neurons. However, the mechanisms used by the parasite to reach the brain remain now largely unknown. Herein we discuss the evidence unravelling the CNS involvement and complexity of neuroimmune interactions that take place in acute and chronic CD. Also, we provide some clues to hypothesize brain infections routes in human and experimental acute CD following oral infection by T. cruzi, an infection route that became a major CD related public health issue in Brazil.https://www.frontiersin.org/articles/10.3389/fimmu.2022.975106/fullChagas diseasecentral nervous systemneuroimmune interactionsencephalitisbrain inflammationoral Trypanosoma cruzi transmission |
spellingShingle | Yerly Useche Ana Rosa Pérez Ana Rosa Pérez Juliana de Meis Juliana de Meis Juliana de Meis Adriana Bonomo Adriana Bonomo Adriana Bonomo Wilson Savino Wilson Savino Wilson Savino Central nervous system commitment in Chagas disease Frontiers in Immunology Chagas disease central nervous system neuroimmune interactions encephalitis brain inflammation oral Trypanosoma cruzi transmission |
title | Central nervous system commitment in Chagas disease |
title_full | Central nervous system commitment in Chagas disease |
title_fullStr | Central nervous system commitment in Chagas disease |
title_full_unstemmed | Central nervous system commitment in Chagas disease |
title_short | Central nervous system commitment in Chagas disease |
title_sort | central nervous system commitment in chagas disease |
topic | Chagas disease central nervous system neuroimmune interactions encephalitis brain inflammation oral Trypanosoma cruzi transmission |
url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.975106/full |
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