Crosstalk between Wnt/β-catenin signaling pathway and DNA damage response in cancer: a new direction for overcoming therapy resistance
Wnt signaling plays an important role in regulating the biological behavior of cancers, and many drugs targeting this signaling have been developed. Recently, a series of research have revealed that Wnt signaling could regulate DNA damage response (DDR) which is crucial for maintaining the genomic i...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-08-01
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| Series: | Frontiers in Pharmacology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2023.1230822/full |
| _version_ | 1827879007193923584 |
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| author | Xixia Zhang Xiaofeng Yu |
| author_facet | Xixia Zhang Xiaofeng Yu |
| author_sort | Xixia Zhang |
| collection | DOAJ |
| description | Wnt signaling plays an important role in regulating the biological behavior of cancers, and many drugs targeting this signaling have been developed. Recently, a series of research have revealed that Wnt signaling could regulate DNA damage response (DDR) which is crucial for maintaining the genomic integrity in cells and closely related to cancer genome instability. Many drugs have been developed to target DNA damage response in cancers. Notably, different components of the Wnt and DDR pathways are involved in crosstalk, forming a complex regulatory network and providing new opportunities for cancer therapy. Here, we provide a brief overview of Wnt signaling and DDR in the field of cancer research and review the interactions between these two pathways. Finally, we also discuss the possibility of therapeutic agents targeting Wnt and DDR as potential cancer treatment strategies. |
| first_indexed | 2024-03-12T18:00:32Z |
| format | Article |
| id | doaj.art-9116b996da024ce89b6b294c72d2c874 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-03-12T18:00:32Z |
| publishDate | 2023-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-9116b996da024ce89b6b294c72d2c8742023-08-02T12:51:13ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122023-08-011410.3389/fphar.2023.12308221230822Crosstalk between Wnt/β-catenin signaling pathway and DNA damage response in cancer: a new direction for overcoming therapy resistanceXixia ZhangXiaofeng YuWnt signaling plays an important role in regulating the biological behavior of cancers, and many drugs targeting this signaling have been developed. Recently, a series of research have revealed that Wnt signaling could regulate DNA damage response (DDR) which is crucial for maintaining the genomic integrity in cells and closely related to cancer genome instability. Many drugs have been developed to target DNA damage response in cancers. Notably, different components of the Wnt and DDR pathways are involved in crosstalk, forming a complex regulatory network and providing new opportunities for cancer therapy. Here, we provide a brief overview of Wnt signaling and DDR in the field of cancer research and review the interactions between these two pathways. Finally, we also discuss the possibility of therapeutic agents targeting Wnt and DDR as potential cancer treatment strategies.https://www.frontiersin.org/articles/10.3389/fphar.2023.1230822/fullWntDNA damage responsecancertherapydrug resistance |
| spellingShingle | Xixia Zhang Xiaofeng Yu Crosstalk between Wnt/β-catenin signaling pathway and DNA damage response in cancer: a new direction for overcoming therapy resistance Frontiers in Pharmacology Wnt DNA damage response cancer therapy drug resistance |
| title | Crosstalk between Wnt/β-catenin signaling pathway and DNA damage response in cancer: a new direction for overcoming therapy resistance |
| title_full | Crosstalk between Wnt/β-catenin signaling pathway and DNA damage response in cancer: a new direction for overcoming therapy resistance |
| title_fullStr | Crosstalk between Wnt/β-catenin signaling pathway and DNA damage response in cancer: a new direction for overcoming therapy resistance |
| title_full_unstemmed | Crosstalk between Wnt/β-catenin signaling pathway and DNA damage response in cancer: a new direction for overcoming therapy resistance |
| title_short | Crosstalk between Wnt/β-catenin signaling pathway and DNA damage response in cancer: a new direction for overcoming therapy resistance |
| title_sort | crosstalk between wnt β catenin signaling pathway and dna damage response in cancer a new direction for overcoming therapy resistance |
| topic | Wnt DNA damage response cancer therapy drug resistance |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2023.1230822/full |
| work_keys_str_mv | AT xixiazhang crosstalkbetweenwntbcateninsignalingpathwayanddnadamageresponseincanceranewdirectionforovercomingtherapyresistance AT xiaofengyu crosstalkbetweenwntbcateninsignalingpathwayanddnadamageresponseincanceranewdirectionforovercomingtherapyresistance |