CARD8 rs2043211 Polymorphism is Associated with Gout in a Chinese Male Population
Background &Aim: Previous studies have suggested genetic factors are involved in the development of gout. We performed a case-control study to investigate the genetic association between CARD8 rs2043211 polymorphism and gout. Methods: A total of 396 male patients with gout and 403 age- and s...
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| Format: | Article |
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Cell Physiol Biochem Press GmbH & Co KG
2015-03-01
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| Series: | Cellular Physiology and Biochemistry |
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| Online Access: | http://www.karger.com/Article/FullText/373960 |
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| author | Ying Chen Xianfeng Ren Changgui Li Shichao Xing Zhengju Fu Ying Yuan Robin Wang Yangang Wang Wenshan Lv |
| author_facet | Ying Chen Xianfeng Ren Changgui Li Shichao Xing Zhengju Fu Ying Yuan Robin Wang Yangang Wang Wenshan Lv |
| author_sort | Ying Chen |
| collection | DOAJ |
| description | Background &Aim: Previous studies have suggested genetic factors are involved in the development of gout. We performed a case-control study to investigate the genetic association between CARD8 rs2043211 polymorphism and gout. Methods: A total of 396 male patients with gout and 403 age- and sex- matched healthy controls were included in this study. Genotyping was performed using TaqMan SNP Genotyping Assays. An association analysis was carried out using the χ2 test. The genotype-phenotype analysis was also conducted. Results: The genotype distribution of CARD8 rs2043211 polymorphism confirmed to HWE in the controls (P = 0.27). There was an obvious difference in the genotype distribution of CARD8 rs2043211 polymorphism between cases and controls (P = 0.017). In addition, there was an obvious association between CARD8 rs2043211 polymorphism and gout under the recessive comparison model (AA vs. TT/TA: OR = 0.65, 95%CI 0.47-0.88, P = 0.006). Patients carrying genotype TT of CARD8 rs2043211 polymorphism had higher triglycerides levels compared to those carrying the AA genotype (2.77±2.08 mmol/L vs. 2.07±1.15 mmol/L, P = 0.01). Patients with the TT genotype also had significantly higher systolic blood pressure compared with those with the AA genotype (142.11±21.10 mmHg vs. 135.38±14.66 mmHg, P = 0.03). Patients carrying TT genotype also had an increased risk of renal calculus compared with those carrying the AA genotype. Conclusion: CARD8 rs2043211 polymorphism is significantly associated with susceptibility to gout in Chinese Han males. |
| first_indexed | 2024-12-12T06:52:24Z |
| format | Article |
| id | doaj.art-91177c2c4c2c46bba936e61f3c750020 |
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| issn | 1015-8987 1421-9778 |
| language | English |
| last_indexed | 2024-12-12T06:52:24Z |
| publishDate | 2015-03-01 |
| publisher | Cell Physiol Biochem Press GmbH & Co KG |
| record_format | Article |
| series | Cellular Physiology and Biochemistry |
| spelling | doaj.art-91177c2c4c2c46bba936e61f3c7500202022-12-22T00:34:02ZengCell Physiol Biochem Press GmbH & Co KGCellular Physiology and Biochemistry1015-89871421-97782015-03-013541394140010.1159/000373960373960CARD8 rs2043211 Polymorphism is Associated with Gout in a Chinese Male PopulationYing ChenXianfeng RenChanggui LiShichao XingZhengju FuYing YuanRobin WangYangang WangWenshan LvBackground &Aim: Previous studies have suggested genetic factors are involved in the development of gout. We performed a case-control study to investigate the genetic association between CARD8 rs2043211 polymorphism and gout. Methods: A total of 396 male patients with gout and 403 age- and sex- matched healthy controls were included in this study. Genotyping was performed using TaqMan SNP Genotyping Assays. An association analysis was carried out using the χ2 test. The genotype-phenotype analysis was also conducted. Results: The genotype distribution of CARD8 rs2043211 polymorphism confirmed to HWE in the controls (P = 0.27). There was an obvious difference in the genotype distribution of CARD8 rs2043211 polymorphism between cases and controls (P = 0.017). In addition, there was an obvious association between CARD8 rs2043211 polymorphism and gout under the recessive comparison model (AA vs. TT/TA: OR = 0.65, 95%CI 0.47-0.88, P = 0.006). Patients carrying genotype TT of CARD8 rs2043211 polymorphism had higher triglycerides levels compared to those carrying the AA genotype (2.77±2.08 mmol/L vs. 2.07±1.15 mmol/L, P = 0.01). Patients with the TT genotype also had significantly higher systolic blood pressure compared with those with the AA genotype (142.11±21.10 mmHg vs. 135.38±14.66 mmHg, P = 0.03). Patients carrying TT genotype also had an increased risk of renal calculus compared with those carrying the AA genotype. Conclusion: CARD8 rs2043211 polymorphism is significantly associated with susceptibility to gout in Chinese Han males.http://www.karger.com/Article/FullText/373960CARD8PolymorphismGout |
| spellingShingle | Ying Chen Xianfeng Ren Changgui Li Shichao Xing Zhengju Fu Ying Yuan Robin Wang Yangang Wang Wenshan Lv CARD8 rs2043211 Polymorphism is Associated with Gout in a Chinese Male Population Cellular Physiology and Biochemistry CARD8 Polymorphism Gout |
| title | CARD8 rs2043211 Polymorphism is Associated with Gout in a Chinese Male Population |
| title_full | CARD8 rs2043211 Polymorphism is Associated with Gout in a Chinese Male Population |
| title_fullStr | CARD8 rs2043211 Polymorphism is Associated with Gout in a Chinese Male Population |
| title_full_unstemmed | CARD8 rs2043211 Polymorphism is Associated with Gout in a Chinese Male Population |
| title_short | CARD8 rs2043211 Polymorphism is Associated with Gout in a Chinese Male Population |
| title_sort | card8 rs2043211 polymorphism is associated with gout in a chinese male population |
| topic | CARD8 Polymorphism Gout |
| url | http://www.karger.com/Article/FullText/373960 |
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