Metabolic Syndrome in Psoriasis Is Associated With Upregulation of CXCL16 on Monocytes and a Dysbalance in Innate Lymphoid Cells
Psoriasis is frequently associated with the metabolic syndrome and occurs more often in obese individuals. In order to understand innate immune mechanisms mediating this inflammatory pattern we investigated expression of the chemokine and lipid scavenger receptor CXCL16 in patients with psoriasis an...
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-06-01
|
| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.916701/full |
| _version_ | 1811244407556407296 |
|---|---|
| author | Lisa Schielke Nick Zimmermann Sarah Hobelsberger Julian Steininger Anne Strunk Kristin Blau Jessica Hernandez Stephan Künzel Robert Ziegenbalg Sarah Rösing Stefan Beissert Susanne Abraham Claudia Günther |
| author_facet | Lisa Schielke Nick Zimmermann Sarah Hobelsberger Julian Steininger Anne Strunk Kristin Blau Jessica Hernandez Stephan Künzel Robert Ziegenbalg Sarah Rösing Stefan Beissert Susanne Abraham Claudia Günther |
| author_sort | Lisa Schielke |
| collection | DOAJ |
| description | Psoriasis is frequently associated with the metabolic syndrome and occurs more often in obese individuals. In order to understand innate immune mechanisms mediating this inflammatory pattern we investigated expression of the chemokine and lipid scavenger receptor CXCL16 in patients with psoriasis and associated comorbidities. CXCL16 expression was enhanced on all monocyte subsets in psoriatic patients compared with healthy controls and positively correlated with psoriasis activity and severity index, body mass index and the risk for cardiovascular disease indicated by PROCAM score. The intensity of CXCL16 expression on monocytes further correlated with their capability to phagocytose oxidized LDL indicating the possibility to transform into foam cells in atherosclerotic plaques. Patients with psoriasis and atherosclerosis or obesity displayed elevated numbers of innate lymphoid cells in blood with specific increase of the IFN-γ or IL-17 producing ILC1 and ILC3 subpopulations. The expression of the CXCL16 receptor, CXCR6, was increased in ILCs and co-expressed with CCR6 but not CCR7 indicating their migratory potential to psoriatic skin or adipose tissue that is characterized by strong CXCL16 and CCL20 expression. This hypothesis was supported by the finding that the percentage of CXCR6 expressing ILCs was alleviated in blood of psoriatic patients. Together these data link a strong expression of CXCL16 to metabolic syndrome in psoriasis and indicate a possible link to ILC activation and tissue distribution in obese psoriatic patients. These data contribute to the understanding of the complex interaction of innate immunity and metabolic state in psoriasis. |
| first_indexed | 2024-04-12T14:23:21Z |
| format | Article |
| id | doaj.art-9117a225696746fbb2e1d7c94ce33e6f |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-12T14:23:21Z |
| publishDate | 2022-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-9117a225696746fbb2e1d7c94ce33e6f2022-12-22T03:29:30ZengFrontiers Media S.A.Frontiers in Immunology1664-32242022-06-011310.3389/fimmu.2022.916701916701Metabolic Syndrome in Psoriasis Is Associated With Upregulation of CXCL16 on Monocytes and a Dysbalance in Innate Lymphoid CellsLisa SchielkeNick ZimmermannSarah HobelsbergerJulian SteiningerAnne StrunkKristin BlauJessica HernandezStephan KünzelRobert ZiegenbalgSarah RösingStefan BeissertSusanne AbrahamClaudia GüntherPsoriasis is frequently associated with the metabolic syndrome and occurs more often in obese individuals. In order to understand innate immune mechanisms mediating this inflammatory pattern we investigated expression of the chemokine and lipid scavenger receptor CXCL16 in patients with psoriasis and associated comorbidities. CXCL16 expression was enhanced on all monocyte subsets in psoriatic patients compared with healthy controls and positively correlated with psoriasis activity and severity index, body mass index and the risk for cardiovascular disease indicated by PROCAM score. The intensity of CXCL16 expression on monocytes further correlated with their capability to phagocytose oxidized LDL indicating the possibility to transform into foam cells in atherosclerotic plaques. Patients with psoriasis and atherosclerosis or obesity displayed elevated numbers of innate lymphoid cells in blood with specific increase of the IFN-γ or IL-17 producing ILC1 and ILC3 subpopulations. The expression of the CXCL16 receptor, CXCR6, was increased in ILCs and co-expressed with CCR6 but not CCR7 indicating their migratory potential to psoriatic skin or adipose tissue that is characterized by strong CXCL16 and CCL20 expression. This hypothesis was supported by the finding that the percentage of CXCR6 expressing ILCs was alleviated in blood of psoriatic patients. Together these data link a strong expression of CXCL16 to metabolic syndrome in psoriasis and indicate a possible link to ILC activation and tissue distribution in obese psoriatic patients. These data contribute to the understanding of the complex interaction of innate immunity and metabolic state in psoriasis.https://www.frontiersin.org/articles/10.3389/fimmu.2022.916701/fullpsoriasisCXCL16ILCmetabolic syndromeobesitymonocytes |
| spellingShingle | Lisa Schielke Nick Zimmermann Sarah Hobelsberger Julian Steininger Anne Strunk Kristin Blau Jessica Hernandez Stephan Künzel Robert Ziegenbalg Sarah Rösing Stefan Beissert Susanne Abraham Claudia Günther Metabolic Syndrome in Psoriasis Is Associated With Upregulation of CXCL16 on Monocytes and a Dysbalance in Innate Lymphoid Cells Frontiers in Immunology psoriasis CXCL16 ILC metabolic syndrome obesity monocytes |
| title | Metabolic Syndrome in Psoriasis Is Associated With Upregulation of CXCL16 on Monocytes and a Dysbalance in Innate Lymphoid Cells |
| title_full | Metabolic Syndrome in Psoriasis Is Associated With Upregulation of CXCL16 on Monocytes and a Dysbalance in Innate Lymphoid Cells |
| title_fullStr | Metabolic Syndrome in Psoriasis Is Associated With Upregulation of CXCL16 on Monocytes and a Dysbalance in Innate Lymphoid Cells |
| title_full_unstemmed | Metabolic Syndrome in Psoriasis Is Associated With Upregulation of CXCL16 on Monocytes and a Dysbalance in Innate Lymphoid Cells |
| title_short | Metabolic Syndrome in Psoriasis Is Associated With Upregulation of CXCL16 on Monocytes and a Dysbalance in Innate Lymphoid Cells |
| title_sort | metabolic syndrome in psoriasis is associated with upregulation of cxcl16 on monocytes and a dysbalance in innate lymphoid cells |
| topic | psoriasis CXCL16 ILC metabolic syndrome obesity monocytes |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.916701/full |
| work_keys_str_mv | AT lisaschielke metabolicsyndromeinpsoriasisisassociatedwithupregulationofcxcl16onmonocytesandadysbalanceininnatelymphoidcells AT nickzimmermann metabolicsyndromeinpsoriasisisassociatedwithupregulationofcxcl16onmonocytesandadysbalanceininnatelymphoidcells AT sarahhobelsberger metabolicsyndromeinpsoriasisisassociatedwithupregulationofcxcl16onmonocytesandadysbalanceininnatelymphoidcells AT juliansteininger metabolicsyndromeinpsoriasisisassociatedwithupregulationofcxcl16onmonocytesandadysbalanceininnatelymphoidcells AT annestrunk metabolicsyndromeinpsoriasisisassociatedwithupregulationofcxcl16onmonocytesandadysbalanceininnatelymphoidcells AT kristinblau metabolicsyndromeinpsoriasisisassociatedwithupregulationofcxcl16onmonocytesandadysbalanceininnatelymphoidcells AT jessicahernandez metabolicsyndromeinpsoriasisisassociatedwithupregulationofcxcl16onmonocytesandadysbalanceininnatelymphoidcells AT stephankunzel metabolicsyndromeinpsoriasisisassociatedwithupregulationofcxcl16onmonocytesandadysbalanceininnatelymphoidcells AT robertziegenbalg metabolicsyndromeinpsoriasisisassociatedwithupregulationofcxcl16onmonocytesandadysbalanceininnatelymphoidcells AT sarahrosing metabolicsyndromeinpsoriasisisassociatedwithupregulationofcxcl16onmonocytesandadysbalanceininnatelymphoidcells AT stefanbeissert metabolicsyndromeinpsoriasisisassociatedwithupregulationofcxcl16onmonocytesandadysbalanceininnatelymphoidcells AT susanneabraham metabolicsyndromeinpsoriasisisassociatedwithupregulationofcxcl16onmonocytesandadysbalanceininnatelymphoidcells AT claudiagunther metabolicsyndromeinpsoriasisisassociatedwithupregulationofcxcl16onmonocytesandadysbalanceininnatelymphoidcells |