Exploring the Metabolic Landscape of AML: From Haematopoietic Stem Cells to Myeloblasts and Leukaemic Stem Cells

Exploring the Metabolic Landscape of AML: From Haematopoietic Stem Cells to Myeloblasts and Leukaemic Stem Cells

Despite intensive chemotherapy regimens, up to 60% of adults with acute myeloid leukaemia (AML) will relapse and eventually succumb to their disease. Recent studies suggest that leukaemic stem cells (LSCs) drive AML relapse by residing in the bone marrow niche and adapting their metabolic profile. M...

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Bibliographic Details
Main Authors: Yashar Mesbahi, Toby N. Trahair, Richard B. Lock, Patrick Connerty
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-02-01
Series:Frontiers in Oncology
Subjects:
acute myeloid leukaemia
metabolic plasticity
leukaemic stem cells
cancer metabolism
metabolic targeting
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.807266/full

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