<i>Anacyclus pyrethrum</i> (L): Chemical Composition, Analgesic, Anti-Inflammatory, and Wound Healing Properties
Background: <i>Anacyclus pyrethrum</i> (<i>A. pyrethrum</i>) is a wild species belonging to the family Asteraceae, which is used in traditional medicines. Aim of the study: This work was undertaken to study the chemical composition, analgesic, anti-inflammatory, and wound hea...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-11-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/25/22/5469 |
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| author | Fatima Zahra Jawhari Abdelfattah El Moussaoui Mohammed Bourhia Hamada Imtara Hamza Mechchate Imane Es-Safi Riaz Ullah Essam Ezzeldin Gamal A. Mostafa Andriy Grafov Samir Ibenmoussa Dalila Bousta Amina Bari |
| author_facet | Fatima Zahra Jawhari Abdelfattah El Moussaoui Mohammed Bourhia Hamada Imtara Hamza Mechchate Imane Es-Safi Riaz Ullah Essam Ezzeldin Gamal A. Mostafa Andriy Grafov Samir Ibenmoussa Dalila Bousta Amina Bari |
| author_sort | Fatima Zahra Jawhari |
| collection | DOAJ |
| description | Background: <i>Anacyclus pyrethrum</i> (<i>A. pyrethrum</i>) is a wild species belonging to the family Asteraceae, which is used in traditional medicines. Aim of the study: This work was undertaken to study the chemical composition, analgesic, anti-inflammatory, and wound healing properties of hydroalcoholic extracts of different parts (roots, seeds, leaves, and capitula) of <i>A. pyrethrum.</i> Material and Methods: The phytochemical analysis of the studied extracts was conducted by GC-MS. The analgesic activity was evaluated in mice using acetic acid and formaldehyde methods. The anti-inflammatory activity was tested using the inhibitory method of edema induced in rats. The healing activity of the hydroethanolic extracts was explored by excision and incision wound healing models in rats. Results: The phytochemical analysis of the studied plant extracts affirmed the presence of interesting compounds, including some newly detected elements, such as sarcosine, <i>N</i>-(trifluoroacetyl)-butyl ester, levulinic acid, malonic acid, palmitic acid, morphinan-6-One, 4,5.alpha.-epoxy-3-hydroxy-17-methyl, 2,4-undecadiene-8,10-diyne-<i>N</i>-tyramide, and isovaleric acid. The extracts of different parts (roots, seeds, leaves, and capitula) exhibited promising anti-inflammatory, analgesic, and wound healing effects, with percentages of inhibition up to 98%, 94%, and 100%, respectively. Conclusion: This study might contribute towards the well-being of society as it provides evidence on the potential analgesic, anti-inflammatory, and wound healing properties of <i>A. pyrethrum</i>. |
| first_indexed | 2024-03-10T14:39:03Z |
| format | Article |
| id | doaj.art-91191b37f3964055bd9da79d77261f26 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T14:39:03Z |
| publishDate | 2020-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-91191b37f3964055bd9da79d77261f262023-11-20T21:56:51ZengMDPI AGMolecules1420-30492020-11-012522546910.3390/molecules25225469<i>Anacyclus pyrethrum</i> (L): Chemical Composition, Analgesic, Anti-Inflammatory, and Wound Healing PropertiesFatima Zahra Jawhari0Abdelfattah El Moussaoui1Mohammed Bourhia2Hamada Imtara3Hamza Mechchate4Imane Es-Safi5Riaz Ullah6Essam Ezzeldin7Gamal A. Mostafa8Andriy Grafov9Samir Ibenmoussa10Dalila Bousta11Amina Bari12Laboratory of Biotechnology, Environment, Agri-Food, and Health (LBEAS), Faculty of Sciences, University Sidi Mohamed Ben Abdellah (USMBA) Fez, Fes 30050, MoroccoLaboratory of Biotechnology, Environment, Agri-Food, and Health (LBEAS), Faculty of Sciences, University Sidi Mohamed Ben Abdellah (USMBA) Fez, Fes 30050, MoroccoLaboratory of Chemistry-Biochemistry, Environment, Nutrition, and Health, Faculty of Medicine and Pharmacy, University of Casablanca, B.P 5696, Casablanca 20250, MoroccoFaculty of Arts and Sciences, Arab American University Palestine, P.O. Box 240, Jenin, PalestineLaboratory of Biotechnology, Environment, Agri-Food, and Health (LBEAS), Faculty of Sciences, University Sidi Mohamed Ben Abdellah (USMBA) Fez, Fes 30050, MoroccoLaboratory of Biotechnology, Environment, Agri-Food, and Health (LBEAS), Faculty of Sciences, University Sidi Mohamed Ben Abdellah (USMBA) Fez, Fes 30050, MoroccoDepartment of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh 11451, Saudi ArabiaDepartment of Pharmaceutical Chemistry, College of Pharmacy King Saud University, Riyadh 11451, Saudi ArabiaDepartment of Pharmaceutical Chemistry, College of Pharmacy King Saud University, Riyadh 11451, Saudi ArabiaDepartment of Chemistry, University of Helsinki, P.O. Box 55, FI-00014 Helsinki, FinlandLaboratory of Chemistry-Biochemistry, Environment, Nutrition, and Health, Faculty of Medicine and Pharmacy, University of Casablanca, B.P 5696, Casablanca 20250, MoroccoLaboratory of Biotechnology, Environment, Agri-Food, and Health (LBEAS), Faculty of Sciences, University Sidi Mohamed Ben Abdellah (USMBA) Fez, Fes 30050, MoroccoLaboratory of Biotechnology, Environment, Agri-Food, and Health (LBEAS), Faculty of Sciences, University Sidi Mohamed Ben Abdellah (USMBA) Fez, Fes 30050, MoroccoBackground: <i>Anacyclus pyrethrum</i> (<i>A. pyrethrum</i>) is a wild species belonging to the family Asteraceae, which is used in traditional medicines. Aim of the study: This work was undertaken to study the chemical composition, analgesic, anti-inflammatory, and wound healing properties of hydroalcoholic extracts of different parts (roots, seeds, leaves, and capitula) of <i>A. pyrethrum.</i> Material and Methods: The phytochemical analysis of the studied extracts was conducted by GC-MS. The analgesic activity was evaluated in mice using acetic acid and formaldehyde methods. The anti-inflammatory activity was tested using the inhibitory method of edema induced in rats. The healing activity of the hydroethanolic extracts was explored by excision and incision wound healing models in rats. Results: The phytochemical analysis of the studied plant extracts affirmed the presence of interesting compounds, including some newly detected elements, such as sarcosine, <i>N</i>-(trifluoroacetyl)-butyl ester, levulinic acid, malonic acid, palmitic acid, morphinan-6-One, 4,5.alpha.-epoxy-3-hydroxy-17-methyl, 2,4-undecadiene-8,10-diyne-<i>N</i>-tyramide, and isovaleric acid. The extracts of different parts (roots, seeds, leaves, and capitula) exhibited promising anti-inflammatory, analgesic, and wound healing effects, with percentages of inhibition up to 98%, 94%, and 100%, respectively. Conclusion: This study might contribute towards the well-being of society as it provides evidence on the potential analgesic, anti-inflammatory, and wound healing properties of <i>A. pyrethrum</i>.https://www.mdpi.com/1420-3049/25/22/5469<i>Anacyclus pyrethrum</i> (L)GC-MS analysisanalgesicanti-inflammatorywound healing |
| spellingShingle | Fatima Zahra Jawhari Abdelfattah El Moussaoui Mohammed Bourhia Hamada Imtara Hamza Mechchate Imane Es-Safi Riaz Ullah Essam Ezzeldin Gamal A. Mostafa Andriy Grafov Samir Ibenmoussa Dalila Bousta Amina Bari <i>Anacyclus pyrethrum</i> (L): Chemical Composition, Analgesic, Anti-Inflammatory, and Wound Healing Properties Molecules <i>Anacyclus pyrethrum</i> (L) GC-MS analysis analgesic anti-inflammatory wound healing |
| title | <i>Anacyclus pyrethrum</i> (L): Chemical Composition, Analgesic, Anti-Inflammatory, and Wound Healing Properties |
| title_full | <i>Anacyclus pyrethrum</i> (L): Chemical Composition, Analgesic, Anti-Inflammatory, and Wound Healing Properties |
| title_fullStr | <i>Anacyclus pyrethrum</i> (L): Chemical Composition, Analgesic, Anti-Inflammatory, and Wound Healing Properties |
| title_full_unstemmed | <i>Anacyclus pyrethrum</i> (L): Chemical Composition, Analgesic, Anti-Inflammatory, and Wound Healing Properties |
| title_short | <i>Anacyclus pyrethrum</i> (L): Chemical Composition, Analgesic, Anti-Inflammatory, and Wound Healing Properties |
| title_sort | i anacyclus pyrethrum i l chemical composition analgesic anti inflammatory and wound healing properties |
| topic | <i>Anacyclus pyrethrum</i> (L) GC-MS analysis analgesic anti-inflammatory wound healing |
| url | https://www.mdpi.com/1420-3049/25/22/5469 |
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