Activities of visual cortical and hippocampal neurons co-fluctuate in freely moving rats during spatial behavior
Visual cues exert a powerful control over hippocampal place cell activities that encode external spaces. The functional interaction of visual cortical neurons and hippocampal place cells during spatial navigation behavior has yet to be elucidated. Here we show that, like hippocampal place cells, man...
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2015-09-01
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| Series: | eLife |
| Subjects: | |
| Online Access: | https://elifesciences.org/articles/08902 |
| _version_ | 1811201024218628096 |
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| author | Daniel Christopher Haggerty Daoyun Ji |
| author_facet | Daniel Christopher Haggerty Daoyun Ji |
| author_sort | Daniel Christopher Haggerty |
| collection | DOAJ |
| description | Visual cues exert a powerful control over hippocampal place cell activities that encode external spaces. The functional interaction of visual cortical neurons and hippocampal place cells during spatial navigation behavior has yet to be elucidated. Here we show that, like hippocampal place cells, many neurons in the primary visual cortex (V1) of freely moving rats selectively fire at specific locations as animals run repeatedly on a track. The V1 location-specific activity leads hippocampal place cell activity both spatially and temporally. The precise activities of individual V1 neurons fluctuate every time the animal travels through the track, in a correlated fashion with those of hippocampal place cells firing at overlapping locations. The results suggest the existence of visual cortical neurons that are functionally coupled with hippocampal place cells for spatial processing during natural behavior. These visual neurons may also participate in the formation and storage of hippocampal-dependent memories. |
| first_indexed | 2024-04-12T02:14:41Z |
| format | Article |
| id | doaj.art-91199938d7944aaba21e034e9a5b6730 |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-12T02:14:41Z |
| publishDate | 2015-09-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-91199938d7944aaba21e034e9a5b67302022-12-22T03:52:18ZengeLife Sciences Publications LtdeLife2050-084X2015-09-01410.7554/eLife.08902Activities of visual cortical and hippocampal neurons co-fluctuate in freely moving rats during spatial behaviorDaniel Christopher Haggerty0Daoyun Ji1Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, United StatesDepartment of Molecular and Cellular Biology, Baylor College of Medicine, Houston, United States; Department of Neuroscience, Baylor College of Medicine, Houston, United StatesVisual cues exert a powerful control over hippocampal place cell activities that encode external spaces. The functional interaction of visual cortical neurons and hippocampal place cells during spatial navigation behavior has yet to be elucidated. Here we show that, like hippocampal place cells, many neurons in the primary visual cortex (V1) of freely moving rats selectively fire at specific locations as animals run repeatedly on a track. The V1 location-specific activity leads hippocampal place cell activity both spatially and temporally. The precise activities of individual V1 neurons fluctuate every time the animal travels through the track, in a correlated fashion with those of hippocampal place cells firing at overlapping locations. The results suggest the existence of visual cortical neurons that are functionally coupled with hippocampal place cells for spatial processing during natural behavior. These visual neurons may also participate in the formation and storage of hippocampal-dependent memories.https://elifesciences.org/articles/08902visual cortexhippocampusplace cellnoise correlationspatial memoryfunctional interaction |
| spellingShingle | Daniel Christopher Haggerty Daoyun Ji Activities of visual cortical and hippocampal neurons co-fluctuate in freely moving rats during spatial behavior eLife visual cortex hippocampus place cell noise correlation spatial memory functional interaction |
| title | Activities of visual cortical and hippocampal neurons co-fluctuate in freely moving rats during spatial behavior |
| title_full | Activities of visual cortical and hippocampal neurons co-fluctuate in freely moving rats during spatial behavior |
| title_fullStr | Activities of visual cortical and hippocampal neurons co-fluctuate in freely moving rats during spatial behavior |
| title_full_unstemmed | Activities of visual cortical and hippocampal neurons co-fluctuate in freely moving rats during spatial behavior |
| title_short | Activities of visual cortical and hippocampal neurons co-fluctuate in freely moving rats during spatial behavior |
| title_sort | activities of visual cortical and hippocampal neurons co fluctuate in freely moving rats during spatial behavior |
| topic | visual cortex hippocampus place cell noise correlation spatial memory functional interaction |
| url | https://elifesciences.org/articles/08902 |
| work_keys_str_mv | AT danielchristopherhaggerty activitiesofvisualcorticalandhippocampalneuronscofluctuateinfreelymovingratsduringspatialbehavior AT daoyunji activitiesofvisualcorticalandhippocampalneuronscofluctuateinfreelymovingratsduringspatialbehavior |