Analysis of Phytonutrients, Anti-Mutagenic and Chemopreventive Effects of Tropical Fruit Extracts
Thailand is located in the tropics and a wide variety of fruits are grown commercially. However, studies regarding the phytonutrients, anti-mutagenic and chemopreventive effects of these fruits are limited. Thus, phytochemical profiles and inhibition of key enzymes involved in obesity and diabetes,...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-10-01
|
| Series: | Foods |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2304-8158/10/11/2600 |
| _version_ | 1827676599420452864 |
|---|---|
| author | Piya Temviriyanukul Suwapat Kittibunchakul Piyapat Trisonthi Woorawee Inthachat Dalad Siriwan Uthaiwan Suttisansanee |
| author_facet | Piya Temviriyanukul Suwapat Kittibunchakul Piyapat Trisonthi Woorawee Inthachat Dalad Siriwan Uthaiwan Suttisansanee |
| author_sort | Piya Temviriyanukul |
| collection | DOAJ |
| description | Thailand is located in the tropics and a wide variety of fruits are grown commercially. However, studies regarding the phytonutrients, anti-mutagenic and chemopreventive effects of these fruits are limited. Thus, phytochemical profiles and inhibition of key enzymes involved in obesity and diabetes, together with anti-mutagenic and chemopreventive properties of eight tropical fruit extracts cultivated in Thailand, including <i>Psidium guajava</i> ‘Kimju’, <i>Psidium guajava</i> ‘Keenok’, <i>Ananas comosus</i> ‘Pattavia’, <i>Ananas comosus</i> ‘Phulae’, <i>Durio zibethinus</i> ‘Chanee’, <i>Durio zibethinus</i> ‘Monthong’, <i>Carica papaya</i> ‘Khaekdum’ and <i>Mangifera indica</i> ‘Namdokmai’ were investigated. Different cultivars were also compared. Results showed that <i>M. indica</i> ‘Namdokmai’ was the most antioxidant-rich extract containing abundant 4-hydroxybenzoic acid and its derivative, gallic acid, as the main phenolics. <i>M. indica</i> ‘Namdokmai’ also exhibited high inhibitory capacities (>60% inhibition under studied conditions) against lipase, α-amylase and α-glucosidase, key enzymes as drug targets for controlling obesity and type 2 diabetes. Interestingly, all fruit extracts suppressed food mutagen-induced DNA mutations assayed by the Ames test, especially <i>M. indica</i> ‘Namdokmai’ and <i>C. papaya</i> ‘Khaekdum’ (>50% inhibition at 200 µg/plate). The <i>M. indica</i> ‘Namdokmai’ was also the most potent extract for suppression of cancer promotion (>90% inhibition at 200 µg/mL) followed by <i>P. guajava</i> ‘Kimju’, <i>P. guajava</i> ‘Keenok’ and <i>C. papaya</i> ‘Khaekdum’. Results potentially indicated that fruit intake after overcooked meat consumption might supplement nutrients and fiber and also reduce DNA mutation sources. |
| first_indexed | 2024-03-10T05:30:39Z |
| format | Article |
| id | doaj.art-911c18de03f84a77a839004ca0965664 |
| institution | Directory Open Access Journal |
| issn | 2304-8158 |
| language | English |
| last_indexed | 2024-03-10T05:30:39Z |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Foods |
| spelling | doaj.art-911c18de03f84a77a839004ca09656642023-11-22T23:19:16ZengMDPI AGFoods2304-81582021-10-011011260010.3390/foods10112600Analysis of Phytonutrients, Anti-Mutagenic and Chemopreventive Effects of Tropical Fruit ExtractsPiya Temviriyanukul0Suwapat Kittibunchakul1Piyapat Trisonthi2Woorawee Inthachat3Dalad Siriwan4Uthaiwan Suttisansanee5Food and Nutrition Academic and Research Cluster, Institute of Nutrition, Mahidol University, Salaya, Phuttamonthon, Nakhon Pathom 73170, ThailandFood and Nutrition Academic and Research Cluster, Institute of Nutrition, Mahidol University, Salaya, Phuttamonthon, Nakhon Pathom 73170, ThailandInstitute of Food Research and Product Development, Kasetsart University, Chatuchak, Bangkok 10900, ThailandFood and Nutrition Academic and Research Cluster, Institute of Nutrition, Mahidol University, Salaya, Phuttamonthon, Nakhon Pathom 73170, ThailandInstitute of Food Research and Product Development, Kasetsart University, Chatuchak, Bangkok 10900, ThailandFood and Nutrition Academic and Research Cluster, Institute of Nutrition, Mahidol University, Salaya, Phuttamonthon, Nakhon Pathom 73170, ThailandThailand is located in the tropics and a wide variety of fruits are grown commercially. However, studies regarding the phytonutrients, anti-mutagenic and chemopreventive effects of these fruits are limited. Thus, phytochemical profiles and inhibition of key enzymes involved in obesity and diabetes, together with anti-mutagenic and chemopreventive properties of eight tropical fruit extracts cultivated in Thailand, including <i>Psidium guajava</i> ‘Kimju’, <i>Psidium guajava</i> ‘Keenok’, <i>Ananas comosus</i> ‘Pattavia’, <i>Ananas comosus</i> ‘Phulae’, <i>Durio zibethinus</i> ‘Chanee’, <i>Durio zibethinus</i> ‘Monthong’, <i>Carica papaya</i> ‘Khaekdum’ and <i>Mangifera indica</i> ‘Namdokmai’ were investigated. Different cultivars were also compared. Results showed that <i>M. indica</i> ‘Namdokmai’ was the most antioxidant-rich extract containing abundant 4-hydroxybenzoic acid and its derivative, gallic acid, as the main phenolics. <i>M. indica</i> ‘Namdokmai’ also exhibited high inhibitory capacities (>60% inhibition under studied conditions) against lipase, α-amylase and α-glucosidase, key enzymes as drug targets for controlling obesity and type 2 diabetes. Interestingly, all fruit extracts suppressed food mutagen-induced DNA mutations assayed by the Ames test, especially <i>M. indica</i> ‘Namdokmai’ and <i>C. papaya</i> ‘Khaekdum’ (>50% inhibition at 200 µg/plate). The <i>M. indica</i> ‘Namdokmai’ was also the most potent extract for suppression of cancer promotion (>90% inhibition at 200 µg/mL) followed by <i>P. guajava</i> ‘Kimju’, <i>P. guajava</i> ‘Keenok’ and <i>C. papaya</i> ‘Khaekdum’. Results potentially indicated that fruit intake after overcooked meat consumption might supplement nutrients and fiber and also reduce DNA mutation sources.https://www.mdpi.com/2304-8158/10/11/2600antioxidantchemopreventionfruits<i>Mangifera indica</i>mutagenicityphytochemicals |
| spellingShingle | Piya Temviriyanukul Suwapat Kittibunchakul Piyapat Trisonthi Woorawee Inthachat Dalad Siriwan Uthaiwan Suttisansanee Analysis of Phytonutrients, Anti-Mutagenic and Chemopreventive Effects of Tropical Fruit Extracts Foods antioxidant chemoprevention fruits <i>Mangifera indica</i> mutagenicity phytochemicals |
| title | Analysis of Phytonutrients, Anti-Mutagenic and Chemopreventive Effects of Tropical Fruit Extracts |
| title_full | Analysis of Phytonutrients, Anti-Mutagenic and Chemopreventive Effects of Tropical Fruit Extracts |
| title_fullStr | Analysis of Phytonutrients, Anti-Mutagenic and Chemopreventive Effects of Tropical Fruit Extracts |
| title_full_unstemmed | Analysis of Phytonutrients, Anti-Mutagenic and Chemopreventive Effects of Tropical Fruit Extracts |
| title_short | Analysis of Phytonutrients, Anti-Mutagenic and Chemopreventive Effects of Tropical Fruit Extracts |
| title_sort | analysis of phytonutrients anti mutagenic and chemopreventive effects of tropical fruit extracts |
| topic | antioxidant chemoprevention fruits <i>Mangifera indica</i> mutagenicity phytochemicals |
| url | https://www.mdpi.com/2304-8158/10/11/2600 |
| work_keys_str_mv | AT piyatemviriyanukul analysisofphytonutrientsantimutagenicandchemopreventiveeffectsoftropicalfruitextracts AT suwapatkittibunchakul analysisofphytonutrientsantimutagenicandchemopreventiveeffectsoftropicalfruitextracts AT piyapattrisonthi analysisofphytonutrientsantimutagenicandchemopreventiveeffectsoftropicalfruitextracts AT wooraweeinthachat analysisofphytonutrientsantimutagenicandchemopreventiveeffectsoftropicalfruitextracts AT daladsiriwan analysisofphytonutrientsantimutagenicandchemopreventiveeffectsoftropicalfruitextracts AT uthaiwansuttisansanee analysisofphytonutrientsantimutagenicandchemopreventiveeffectsoftropicalfruitextracts |