Evaluation of extracts from Sida acuta, Phyllanthus amarus, Parkia biglobosa and their herbal ointment for therapeutic and biological activities
Herbal extracts are a well-known source of therapeutically important bioactive chemicals since they are widely available, relatively inexpensive, and have fewer adverse effects. The three plants' leaves have been used to treat a variety of illnesses in Ghana, including skin conditions and wound...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-09-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844023065246 |
| _version_ | 1797669915829731328 |
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| author | Addai-Mensah Donkor Benjamin Ahenkorah Timothy Ajigepungu Wallah Abdallah Yakubu |
| author_facet | Addai-Mensah Donkor Benjamin Ahenkorah Timothy Ajigepungu Wallah Abdallah Yakubu |
| author_sort | Addai-Mensah Donkor |
| collection | DOAJ |
| description | Herbal extracts are a well-known source of therapeutically important bioactive chemicals since they are widely available, relatively inexpensive, and have fewer adverse effects. The three plants' leaves have been used to treat a variety of illnesses in Ghana, including skin conditions and wound infections. Their effectiveness as an ointment in treating the aforementioned illnesses has not yet been shown, though.The extracts were made into an ointment with polyethylene glycol (PEG), and both the ointment and the raw extracts were examined for in vitro antibacterial activity. The three (3) chosen bacterial isolates were subjected to potential activities of the plant extracts from different extractants.The minimum bactericidal concentration (MBC) and minimum inhibitory concentration (MIC) values for the plant extracts were both low. The herbal ointment made with Sida acuta extract from both extractants showed significantly different activity (P < 0.05), against the test pathogens when compared to the reference medication (Madecassol®). However, the activities of formulated herbal ointment from both P. amarus and P. biglobosa extracts were comparable at higher concentrations to the standard drug used. Notably, both plant extracts and extract-PEG manufactured ointments exhibit significant in vitro efficacy against the disease-causing bacterial species.The current study is the first in-depth account of Parkia species with regard to an examination of herbal ointments made from leaves extract obtained utilizing solvents such as water and ethanol. Our research findings have important implications for the pharmaceutical industry in terms of providing a suitable, workable, and alternative supply of bioactive compounds and anti-infective agents. |
| first_indexed | 2024-03-11T20:51:48Z |
| format | Article |
| id | doaj.art-911c6293764743f3b307f5204999fc7d |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-03-11T20:51:48Z |
| publishDate | 2023-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-911c6293764743f3b307f5204999fc7d2023-10-01T05:59:10ZengElsevierHeliyon2405-84402023-09-0199e19316Evaluation of extracts from Sida acuta, Phyllanthus amarus, Parkia biglobosa and their herbal ointment for therapeutic and biological activitiesAddai-Mensah Donkor0Benjamin Ahenkorah1Timothy Ajigepungu Wallah2Abdallah Yakubu3Department of Pharmaceutics, School of Pharmacy and Pharmaceutical Sciences, University for Development Studies, Tamale, Ghana; Department of Pharmaceutical Chemistry, School of Pharmacy and Pharmaceutical Sciences, University for Development Studies, Tamale, Ghana; Corresponding author. Department of Pharmaceutics, School of Pharmacy and Pharmaceutical Sciences, University for Development Studies, Tamale, Ghana.Department of Medical Laboratory Science, Bolgatanga Technical University, Bolgatanga, Upper East Region, Ghana; Corresponding author.Department of Applied Chemistry, University for Development Studies, Tamale, GhanaDepartment of Pharmaceutical Chemistry, School of Pharmacy and Pharmaceutical Sciences, University for Development Studies, Tamale, GhanaHerbal extracts are a well-known source of therapeutically important bioactive chemicals since they are widely available, relatively inexpensive, and have fewer adverse effects. The three plants' leaves have been used to treat a variety of illnesses in Ghana, including skin conditions and wound infections. Their effectiveness as an ointment in treating the aforementioned illnesses has not yet been shown, though.The extracts were made into an ointment with polyethylene glycol (PEG), and both the ointment and the raw extracts were examined for in vitro antibacterial activity. The three (3) chosen bacterial isolates were subjected to potential activities of the plant extracts from different extractants.The minimum bactericidal concentration (MBC) and minimum inhibitory concentration (MIC) values for the plant extracts were both low. The herbal ointment made with Sida acuta extract from both extractants showed significantly different activity (P < 0.05), against the test pathogens when compared to the reference medication (Madecassol®). However, the activities of formulated herbal ointment from both P. amarus and P. biglobosa extracts were comparable at higher concentrations to the standard drug used. Notably, both plant extracts and extract-PEG manufactured ointments exhibit significant in vitro efficacy against the disease-causing bacterial species.The current study is the first in-depth account of Parkia species with regard to an examination of herbal ointments made from leaves extract obtained utilizing solvents such as water and ethanol. Our research findings have important implications for the pharmaceutical industry in terms of providing a suitable, workable, and alternative supply of bioactive compounds and anti-infective agents.http://www.sciencedirect.com/science/article/pii/S2405844023065246Escherichia coliStaphylococcus aureusParkia biglobosaSida acutaPolyethylene glycol (PEG)Pseudomonas aeruginosa |
| spellingShingle | Addai-Mensah Donkor Benjamin Ahenkorah Timothy Ajigepungu Wallah Abdallah Yakubu Evaluation of extracts from Sida acuta, Phyllanthus amarus, Parkia biglobosa and their herbal ointment for therapeutic and biological activities Heliyon Escherichia coli Staphylococcus aureus Parkia biglobosa Sida acuta Polyethylene glycol (PEG) Pseudomonas aeruginosa |
| title | Evaluation of extracts from Sida acuta, Phyllanthus amarus, Parkia biglobosa and their herbal ointment for therapeutic and biological activities |
| title_full | Evaluation of extracts from Sida acuta, Phyllanthus amarus, Parkia biglobosa and their herbal ointment for therapeutic and biological activities |
| title_fullStr | Evaluation of extracts from Sida acuta, Phyllanthus amarus, Parkia biglobosa and their herbal ointment for therapeutic and biological activities |
| title_full_unstemmed | Evaluation of extracts from Sida acuta, Phyllanthus amarus, Parkia biglobosa and their herbal ointment for therapeutic and biological activities |
| title_short | Evaluation of extracts from Sida acuta, Phyllanthus amarus, Parkia biglobosa and their herbal ointment for therapeutic and biological activities |
| title_sort | evaluation of extracts from sida acuta phyllanthus amarus parkia biglobosa and their herbal ointment for therapeutic and biological activities |
| topic | Escherichia coli Staphylococcus aureus Parkia biglobosa Sida acuta Polyethylene glycol (PEG) Pseudomonas aeruginosa |
| url | http://www.sciencedirect.com/science/article/pii/S2405844023065246 |
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