The Mediation Role of Dynamic Multisensory Processing Using Molecular Genetic Data in Dyslexia
Although substantial heritability has been reported and candidate genes have been identified, we are far from understanding the etiopathogenetic pathways underlying developmental dyslexia (DD). Reading-related endophenotypes (EPs) have been established. Until now it was unknown whether they mediated...
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MDPI AG
2020-12-01
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| Series: | Brain Sciences |
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| Online Access: | https://www.mdpi.com/2076-3425/10/12/993 |
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| author | Sara Mascheretti Valentina Riva Bei Feng Vittoria Trezzi Chiara Andreola Roberto Giorda Marco Villa Ginette Dionne Simone Gori Cecilia Marino Andrea Facoetti |
| author_facet | Sara Mascheretti Valentina Riva Bei Feng Vittoria Trezzi Chiara Andreola Roberto Giorda Marco Villa Ginette Dionne Simone Gori Cecilia Marino Andrea Facoetti |
| author_sort | Sara Mascheretti |
| collection | DOAJ |
| description | Although substantial heritability has been reported and candidate genes have been identified, we are far from understanding the etiopathogenetic pathways underlying developmental dyslexia (DD). Reading-related endophenotypes (EPs) have been established. Until now it was unknown whether they mediated the pathway from gene to reading (dis)ability. Thus, in a sample of 223 siblings from nuclear families with DD and 79 unrelated typical readers, we tested four EPs (i.e., rapid auditory processing, rapid automatized naming, multisensory nonspatial attention and visual motion processing) and 20 markers spanning five DD-candidate genes (i.e., <i>DYX1C1</i>, <i>DCDC2</i>, <i>KIAA0319</i>, <i>ROBO1</i> and <i>GRIN2B</i>) using a multiple-predictor/multiple-mediator framework. Our results show that rapid auditory and visual motion processing are mediators in the pathway from <i>ROBO1</i>-rs9853895 to reading. Specifically, the T/T genotype group predicts impairments in rapid auditory and visual motion processing which, in turn, predict poorer reading skills. Our results suggest that <i>ROBO1</i> is related to reading via multisensory temporal processing. These findings support the use of EPs as an effective approach to disentangling the complex pathways between candidate genes and behavior. |
| first_indexed | 2024-03-10T14:02:12Z |
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| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-10T14:02:12Z |
| publishDate | 2020-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj.art-911f255a2ab745648b7ae4592d5fdce02023-11-21T01:01:55ZengMDPI AGBrain Sciences2076-34252020-12-01101299310.3390/brainsci10120993The Mediation Role of Dynamic Multisensory Processing Using Molecular Genetic Data in DyslexiaSara Mascheretti0Valentina Riva1Bei Feng2Vittoria Trezzi3Chiara Andreola4Roberto Giorda5Marco Villa6Ginette Dionne7Simone Gori8Cecilia Marino9Andrea Facoetti10Child Psychopathology Unit, Scientific Institute, IRCCS E. Medea, 23842 Bosisio Parini, ItalyChild Psychopathology Unit, Scientific Institute, IRCCS E. Medea, 23842 Bosisio Parini, ItalyÉcole de Psychologie, Laval University, Québec, QC G1V 0A6, CanadaChild Psychopathology Unit, Scientific Institute, IRCCS E. Medea, 23842 Bosisio Parini, ItalyChild Psychopathology Unit, Scientific Institute, IRCCS E. Medea, 23842 Bosisio Parini, ItalyMolecular Biology Laboratory, Scientific Institute, IRCCS E. Medea, 23842 Bosisio Parini, ItalyMolecular Biology Laboratory, Scientific Institute, IRCCS E. Medea, 23842 Bosisio Parini, ItalyÉcole de Psychologie, Laval University, Québec, QC G1V 0A6, CanadaDepartment of Human and Social Sciences, University of Bergamo, 24100 Bergamo, ItalyChild Psychopathology Unit, Scientific Institute, IRCCS E. Medea, 23842 Bosisio Parini, ItalyDevelopmental Cognitive Neuroscience Lab, Department of General Psychology, University of Padua, 35131 Padua, ItalyAlthough substantial heritability has been reported and candidate genes have been identified, we are far from understanding the etiopathogenetic pathways underlying developmental dyslexia (DD). Reading-related endophenotypes (EPs) have been established. Until now it was unknown whether they mediated the pathway from gene to reading (dis)ability. Thus, in a sample of 223 siblings from nuclear families with DD and 79 unrelated typical readers, we tested four EPs (i.e., rapid auditory processing, rapid automatized naming, multisensory nonspatial attention and visual motion processing) and 20 markers spanning five DD-candidate genes (i.e., <i>DYX1C1</i>, <i>DCDC2</i>, <i>KIAA0319</i>, <i>ROBO1</i> and <i>GRIN2B</i>) using a multiple-predictor/multiple-mediator framework. Our results show that rapid auditory and visual motion processing are mediators in the pathway from <i>ROBO1</i>-rs9853895 to reading. Specifically, the T/T genotype group predicts impairments in rapid auditory and visual motion processing which, in turn, predict poorer reading skills. Our results suggest that <i>ROBO1</i> is related to reading via multisensory temporal processing. These findings support the use of EPs as an effective approach to disentangling the complex pathways between candidate genes and behavior.https://www.mdpi.com/2076-3425/10/12/993candidate genesdevelopmental dyslexiaendophenotypesmediationmultisensory temporal processing |
| spellingShingle | Sara Mascheretti Valentina Riva Bei Feng Vittoria Trezzi Chiara Andreola Roberto Giorda Marco Villa Ginette Dionne Simone Gori Cecilia Marino Andrea Facoetti The Mediation Role of Dynamic Multisensory Processing Using Molecular Genetic Data in Dyslexia Brain Sciences candidate genes developmental dyslexia endophenotypes mediation multisensory temporal processing |
| title | The Mediation Role of Dynamic Multisensory Processing Using Molecular Genetic Data in Dyslexia |
| title_full | The Mediation Role of Dynamic Multisensory Processing Using Molecular Genetic Data in Dyslexia |
| title_fullStr | The Mediation Role of Dynamic Multisensory Processing Using Molecular Genetic Data in Dyslexia |
| title_full_unstemmed | The Mediation Role of Dynamic Multisensory Processing Using Molecular Genetic Data in Dyslexia |
| title_short | The Mediation Role of Dynamic Multisensory Processing Using Molecular Genetic Data in Dyslexia |
| title_sort | mediation role of dynamic multisensory processing using molecular genetic data in dyslexia |
| topic | candidate genes developmental dyslexia endophenotypes mediation multisensory temporal processing |
| url | https://www.mdpi.com/2076-3425/10/12/993 |
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