The Development of the Bengamides as New Antibiotics against Drug-Resistant Bacteria
The bengamides comprise an interesting family of natural products isolated from sponges belonging to the prolific <i>Jaspidae</i> family. Their outstanding antitumor properties, coupled with their unique mechanism of action and unprecedented molecular structures, have prompted an intense...
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| Materyal Türü: | Makale |
| Dil: | English |
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MDPI AG
2022-05-01
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| Seri Bilgileri: | Marine Drugs |
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| Online Erişim: | https://www.mdpi.com/1660-3397/20/6/373 |
| _version_ | 1827659029253455872 |
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| author | Cristina Porras-Alcalá Federico Moya-Utrera Miguel García-Castro Antonio Sánchez-Ruiz Juan Manuel López-Romero María Soledad Pino-González Amelia Díaz-Morilla Seiya Kitamura Dennis W. Wolan José Prados Consolación Melguizo Iván Cheng-Sánchez Francisco Sarabia |
| author_facet | Cristina Porras-Alcalá Federico Moya-Utrera Miguel García-Castro Antonio Sánchez-Ruiz Juan Manuel López-Romero María Soledad Pino-González Amelia Díaz-Morilla Seiya Kitamura Dennis W. Wolan José Prados Consolación Melguizo Iván Cheng-Sánchez Francisco Sarabia |
| author_sort | Cristina Porras-Alcalá |
| collection | DOAJ |
| description | The bengamides comprise an interesting family of natural products isolated from sponges belonging to the prolific <i>Jaspidae</i> family. Their outstanding antitumor properties, coupled with their unique mechanism of action and unprecedented molecular structures, have prompted an intense research activity directed towards their total syntheses, analogue design, and biological evaluations for their development as new anticancer agents. Together with these biological studies in cancer research, in recent years, the bengamides have been identified as potential antibiotics by their impressive biological activities against various drug-resistant bacteria such as <i>Mycobacterium tuberculosis</i> and <i>Staphylococcus aureus</i>. This review reports on the new advances in the chemistry and biology of the bengamides during the last years, paying special attention to their development as promising new antibiotics. Thus, the evolution of the bengamides from their initial exploration as antitumor agents up to their current status as antibiotics is described in detail, highlighting the manifold value of these marine natural products as valid hits in medicinal chemistry. |
| first_indexed | 2024-03-09T23:12:51Z |
| format | Article |
| id | doaj.art-911f3f8f26284067b4c15c03b7fdddd9 |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-03-09T23:12:51Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-911f3f8f26284067b4c15c03b7fdddd92023-11-23T17:41:06ZengMDPI AGMarine Drugs1660-33972022-05-0120637310.3390/md20060373The Development of the Bengamides as New Antibiotics against Drug-Resistant BacteriaCristina Porras-Alcalá0Federico Moya-Utrera1Miguel García-Castro2Antonio Sánchez-Ruiz3Juan Manuel López-Romero4María Soledad Pino-González5Amelia Díaz-Morilla6Seiya Kitamura7Dennis W. Wolan8José Prados9Consolación Melguizo10Iván Cheng-Sánchez11Francisco Sarabia12Department of Organic Chemistry, Faculty of Sciences, University of Malaga, 29071 Málaga, SpainDepartment of Organic Chemistry, Faculty of Sciences, University of Malaga, 29071 Málaga, SpainDepartment of Organic Chemistry, Faculty of Sciences, University of Malaga, 29071 Málaga, SpainFaculty of Pharmacy, Campus de Albacete, Universidad de Castilla-La Mancha, 02008 Albacete, SpainDepartment of Organic Chemistry, Faculty of Sciences, University of Malaga, 29071 Málaga, SpainDepartment of Organic Chemistry, Faculty of Sciences, University of Malaga, 29071 Málaga, SpainDepartment of Organic Chemistry, Faculty of Sciences, University of Malaga, 29071 Málaga, SpainDepartment of Molecular Medicine, The Scripps Research Institute, San Diego, CA 92037, USADepartment of Molecular Medicine, The Scripps Research Institute, San Diego, CA 92037, USACenter of Biomedical Research (CIBM), Institute of Biopathology and Regenerative Medicine (IBIMER), University of Granada, 18100 Granada, SpainCenter of Biomedical Research (CIBM), Institute of Biopathology and Regenerative Medicine (IBIMER), University of Granada, 18100 Granada, SpainDepartment of Chemistry, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, SwitzerlandDepartment of Organic Chemistry, Faculty of Sciences, University of Malaga, 29071 Málaga, SpainThe bengamides comprise an interesting family of natural products isolated from sponges belonging to the prolific <i>Jaspidae</i> family. Their outstanding antitumor properties, coupled with their unique mechanism of action and unprecedented molecular structures, have prompted an intense research activity directed towards their total syntheses, analogue design, and biological evaluations for their development as new anticancer agents. Together with these biological studies in cancer research, in recent years, the bengamides have been identified as potential antibiotics by their impressive biological activities against various drug-resistant bacteria such as <i>Mycobacterium tuberculosis</i> and <i>Staphylococcus aureus</i>. This review reports on the new advances in the chemistry and biology of the bengamides during the last years, paying special attention to their development as promising new antibiotics. Thus, the evolution of the bengamides from their initial exploration as antitumor agents up to their current status as antibiotics is described in detail, highlighting the manifold value of these marine natural products as valid hits in medicinal chemistry.https://www.mdpi.com/1660-3397/20/6/373bengamidesantibioticsdrug-resistant bacteriaantitumor agentsSAR |
| spellingShingle | Cristina Porras-Alcalá Federico Moya-Utrera Miguel García-Castro Antonio Sánchez-Ruiz Juan Manuel López-Romero María Soledad Pino-González Amelia Díaz-Morilla Seiya Kitamura Dennis W. Wolan José Prados Consolación Melguizo Iván Cheng-Sánchez Francisco Sarabia The Development of the Bengamides as New Antibiotics against Drug-Resistant Bacteria Marine Drugs bengamides antibiotics drug-resistant bacteria antitumor agents SAR |
| title | The Development of the Bengamides as New Antibiotics against Drug-Resistant Bacteria |
| title_full | The Development of the Bengamides as New Antibiotics against Drug-Resistant Bacteria |
| title_fullStr | The Development of the Bengamides as New Antibiotics against Drug-Resistant Bacteria |
| title_full_unstemmed | The Development of the Bengamides as New Antibiotics against Drug-Resistant Bacteria |
| title_short | The Development of the Bengamides as New Antibiotics against Drug-Resistant Bacteria |
| title_sort | development of the bengamides as new antibiotics against drug resistant bacteria |
| topic | bengamides antibiotics drug-resistant bacteria antitumor agents SAR |
| url | https://www.mdpi.com/1660-3397/20/6/373 |
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