Diagnostic Efficacy of Serological Antibody Detection Tests for Hepatitis Delta Virus: A Systematic Review and Meta-Analysis
Background and Aims Coinfection of hepatitis delta virus (HDV) with hepatitis B virus (HBV) causes the most severe form of viral hepatitis, and the global prevalence of HDV infection is underestimated. Although serological testing of anti-HDV antibodies is widely used in the diagnosis of HDV, its di...
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| Format: | Article |
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MDPI AG
2023-11-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/15/12/2345 |
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| author | Zhenzhen Pan Sisi Chen Ling Xu Yao Gao Yaling Cao Zihao Fan Yuan Tian Xiangying Zhang Zhongping Duan Feng Ren |
| author_facet | Zhenzhen Pan Sisi Chen Ling Xu Yao Gao Yaling Cao Zihao Fan Yuan Tian Xiangying Zhang Zhongping Duan Feng Ren |
| author_sort | Zhenzhen Pan |
| collection | DOAJ |
| description | Background and Aims Coinfection of hepatitis delta virus (HDV) with hepatitis B virus (HBV) causes the most severe form of viral hepatitis, and the global prevalence of HDV infection is underestimated. Although serological testing of anti-HDV antibodies is widely used in the diagnosis of HDV, its diagnostic efficacy remains unclear. This study aimed to evaluate the diagnostic efficacy of HDV serological tests, the results of which may assist in the diagnosis of HDV. Methods Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines were followed. The PubMed, Web of Science and Cochrane Library databases were searched from the beginning to 31 May 2023. Study quality was assessed using the Quality Assessment of Diagnostic Accuracy Studies-2 (QUADAS-2) tool. STATA SE was used for the meta-analysis of the sensitivity, specificity, positive likelihood ratio and negative likelihood ratio. Results Among a total of 1376 initially identified studies, only 12 articles met the final inclusion criteria. The pooled sensitivity and specificity were 1.00 (95% CI: 0.00–1.00) and 0.71 (95% CI: 0.50–0.78) for HDV total antibodies, 0.96 (95% CI: 0.83–0.99) and 0.98 (95% CI: 0.82–1.00) for anti-HDV IgM and 0.95 (95% CI: 0.86–0.98) and 0.96 (95% CI: 0.67–1.00) for anti-HDV IgG. The pooled sensitivity and specificity for HDV serological tests were 0.99 (95% CI: 0.96–1.00) and 0.90 (95% CI: 0.79–0.96). Conclusions This meta-analysis suggests that serological tests have high diagnostic performance in detecting antibodies against HDV, especially in HDV IgM and IgG. However, this conclusion is based on studies of a limited number and quality, and the development of new diagnostic tools with higher precision and reliability is still necessary. |
| first_indexed | 2024-03-08T20:17:19Z |
| format | Article |
| id | doaj.art-911fed2d930847e3861ad4cb8ec5eb50 |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-08T20:17:19Z |
| publishDate | 2023-11-01 |
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| record_format | Article |
| series | Viruses |
| spelling | doaj.art-911fed2d930847e3861ad4cb8ec5eb502023-12-22T14:49:09ZengMDPI AGViruses1999-49152023-11-011512234510.3390/v15122345Diagnostic Efficacy of Serological Antibody Detection Tests for Hepatitis Delta Virus: A Systematic Review and Meta-AnalysisZhenzhen Pan0Sisi Chen1Ling Xu2Yao Gao3Yaling Cao4Zihao Fan5Yuan Tian6Xiangying Zhang7Zhongping Duan8Feng Ren9Beijing Institute of Hepatology/Beijing Youan Hospital, Capital Medical University, Beijing 100069, ChinaBeijing Youan Hospital, Capital Medical University, Beijing 100069, ChinaBeijing Institute of Hepatology/Beijing Youan Hospital, Capital Medical University, Beijing 100069, ChinaBeijing Institute of Hepatology/Beijing Youan Hospital, Capital Medical University, Beijing 100069, ChinaBeijing Institute of Hepatology/Beijing Youan Hospital, Capital Medical University, Beijing 100069, ChinaBeijing Institute of Hepatology/Beijing Youan Hospital, Capital Medical University, Beijing 100069, ChinaBeijing Institute of Hepatology/Beijing Youan Hospital, Capital Medical University, Beijing 100069, ChinaBeijing Institute of Hepatology/Beijing Youan Hospital, Capital Medical University, Beijing 100069, ChinaBeijing Youan Hospital, Capital Medical University, Beijing 100069, ChinaBeijing Institute of Hepatology/Beijing Youan Hospital, Capital Medical University, Beijing 100069, ChinaBackground and Aims Coinfection of hepatitis delta virus (HDV) with hepatitis B virus (HBV) causes the most severe form of viral hepatitis, and the global prevalence of HDV infection is underestimated. Although serological testing of anti-HDV antibodies is widely used in the diagnosis of HDV, its diagnostic efficacy remains unclear. This study aimed to evaluate the diagnostic efficacy of HDV serological tests, the results of which may assist in the diagnosis of HDV. Methods Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines were followed. The PubMed, Web of Science and Cochrane Library databases were searched from the beginning to 31 May 2023. Study quality was assessed using the Quality Assessment of Diagnostic Accuracy Studies-2 (QUADAS-2) tool. STATA SE was used for the meta-analysis of the sensitivity, specificity, positive likelihood ratio and negative likelihood ratio. Results Among a total of 1376 initially identified studies, only 12 articles met the final inclusion criteria. The pooled sensitivity and specificity were 1.00 (95% CI: 0.00–1.00) and 0.71 (95% CI: 0.50–0.78) for HDV total antibodies, 0.96 (95% CI: 0.83–0.99) and 0.98 (95% CI: 0.82–1.00) for anti-HDV IgM and 0.95 (95% CI: 0.86–0.98) and 0.96 (95% CI: 0.67–1.00) for anti-HDV IgG. The pooled sensitivity and specificity for HDV serological tests were 0.99 (95% CI: 0.96–1.00) and 0.90 (95% CI: 0.79–0.96). Conclusions This meta-analysis suggests that serological tests have high diagnostic performance in detecting antibodies against HDV, especially in HDV IgM and IgG. However, this conclusion is based on studies of a limited number and quality, and the development of new diagnostic tools with higher precision and reliability is still necessary.https://www.mdpi.com/1999-4915/15/12/2345hepatitis delta virusantibody detectionserological testingdiagnostic performancemeta-analysis |
| spellingShingle | Zhenzhen Pan Sisi Chen Ling Xu Yao Gao Yaling Cao Zihao Fan Yuan Tian Xiangying Zhang Zhongping Duan Feng Ren Diagnostic Efficacy of Serological Antibody Detection Tests for Hepatitis Delta Virus: A Systematic Review and Meta-Analysis Viruses hepatitis delta virus antibody detection serological testing diagnostic performance meta-analysis |
| title | Diagnostic Efficacy of Serological Antibody Detection Tests for Hepatitis Delta Virus: A Systematic Review and Meta-Analysis |
| title_full | Diagnostic Efficacy of Serological Antibody Detection Tests for Hepatitis Delta Virus: A Systematic Review and Meta-Analysis |
| title_fullStr | Diagnostic Efficacy of Serological Antibody Detection Tests for Hepatitis Delta Virus: A Systematic Review and Meta-Analysis |
| title_full_unstemmed | Diagnostic Efficacy of Serological Antibody Detection Tests for Hepatitis Delta Virus: A Systematic Review and Meta-Analysis |
| title_short | Diagnostic Efficacy of Serological Antibody Detection Tests for Hepatitis Delta Virus: A Systematic Review and Meta-Analysis |
| title_sort | diagnostic efficacy of serological antibody detection tests for hepatitis delta virus a systematic review and meta analysis |
| topic | hepatitis delta virus antibody detection serological testing diagnostic performance meta-analysis |
| url | https://www.mdpi.com/1999-4915/15/12/2345 |
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