Association of –1082A>G Polymorphism in the Interleukin-10 Gene with Estimated Glomerular Filtration Rate in Type 2 Diabetes
Background/Aims: The -1082A>G polymorphism (rs1800896) in the interleukin-10 (IL10) gene has been associated with type 2 diabetes and diabetic retinopathy, but its relationship with diabetic kidney disease (DKD) is uncertain. The aim of this case-control study was to investigate whether the...
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| Format: | Article |
| Language: | English |
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Karger Publishers
2017-12-01
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| Series: | Kidney & Blood Pressure Research |
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| Online Access: | https://www.karger.com/Article/FullText/485863 |
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| author | Evelise Regina Polina Bruna Letícia da Silva Pereira Daisy Crispim Renan Cesar Sbruzzi Luis Henrique Canani Kátia Gonçalves dos Santos |
| author_facet | Evelise Regina Polina Bruna Letícia da Silva Pereira Daisy Crispim Renan Cesar Sbruzzi Luis Henrique Canani Kátia Gonçalves dos Santos |
| author_sort | Evelise Regina Polina |
| collection | DOAJ |
| description | Background/Aims: The -1082A>G polymorphism (rs1800896) in the interleukin-10 (IL10) gene has been associated with type 2 diabetes and diabetic retinopathy, but its relationship with diabetic kidney disease (DKD) is uncertain. The aim of this case-control study was to investigate whether the -1082A>G polymorphism is associated with DKD in white Brazilians with type 2 diabetes mellitus. Methods: Genotyping was done by real-time polymerase chain reaction for 597 type 2 diabetic outpatients. The definition of DKD was based on estimated glomerular filtration rate (eGFR) and albuminuria, and the patients were grouped in three categories: no DKD (n=249), mild to moderate DKD (n=222), and severe DKD (n=126). Results: The frequency of the minor (G) allele in subjects without DKD did not differ from that observed in subjects with DKD (0.35 vs 0.39, respectively; P = 0.192). Genotype frequencies in subjects without DKD were not significantly different from those observed among patients with mild to moderate DKD or severe DKD. However, considering only the eGFR categories as an indicator of renal function, the AG genotype was independently associated with an increased risk of mildly to moderately decreased eGFR (G3a category) and GG genotype was independently associated with increased risk of kidney failure (G5 category) as compared with AA genotype. Conclusion: Our findings support the hypothesis that the -1082A>G polymorphism in the IL10 gene might be associated with DKD in white Brazilians with type 2 diabetes. |
| first_indexed | 2024-12-13T08:53:59Z |
| format | Article |
| id | doaj.art-91204f52c42a4eaa8979c383278ed54e |
| institution | Directory Open Access Journal |
| issn | 1420-4096 1423-0143 |
| language | English |
| last_indexed | 2024-12-13T08:53:59Z |
| publishDate | 2017-12-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Kidney & Blood Pressure Research |
| spelling | doaj.art-91204f52c42a4eaa8979c383278ed54e2022-12-21T23:53:19ZengKarger PublishersKidney & Blood Pressure Research1420-40961423-01432017-12-014261164117410.1159/000485863485863Association of –1082A>G Polymorphism in the Interleukin-10 Gene with Estimated Glomerular Filtration Rate in Type 2 DiabetesEvelise Regina PolinaBruna Letícia da Silva PereiraDaisy CrispimRenan Cesar SbruzziLuis Henrique CananiKátia Gonçalves dos SantosBackground/Aims: The -1082A>G polymorphism (rs1800896) in the interleukin-10 (IL10) gene has been associated with type 2 diabetes and diabetic retinopathy, but its relationship with diabetic kidney disease (DKD) is uncertain. The aim of this case-control study was to investigate whether the -1082A>G polymorphism is associated with DKD in white Brazilians with type 2 diabetes mellitus. Methods: Genotyping was done by real-time polymerase chain reaction for 597 type 2 diabetic outpatients. The definition of DKD was based on estimated glomerular filtration rate (eGFR) and albuminuria, and the patients were grouped in three categories: no DKD (n=249), mild to moderate DKD (n=222), and severe DKD (n=126). Results: The frequency of the minor (G) allele in subjects without DKD did not differ from that observed in subjects with DKD (0.35 vs 0.39, respectively; P = 0.192). Genotype frequencies in subjects without DKD were not significantly different from those observed among patients with mild to moderate DKD or severe DKD. However, considering only the eGFR categories as an indicator of renal function, the AG genotype was independently associated with an increased risk of mildly to moderately decreased eGFR (G3a category) and GG genotype was independently associated with increased risk of kidney failure (G5 category) as compared with AA genotype. Conclusion: Our findings support the hypothesis that the -1082A>G polymorphism in the IL10 gene might be associated with DKD in white Brazilians with type 2 diabetes.https://www.karger.com/Article/FullText/485863Type 2 diabetesDiabetic kidney diseaseEGFRInterleukin-10Polymorphism |
| spellingShingle | Evelise Regina Polina Bruna Letícia da Silva Pereira Daisy Crispim Renan Cesar Sbruzzi Luis Henrique Canani Kátia Gonçalves dos Santos Association of –1082A>G Polymorphism in the Interleukin-10 Gene with Estimated Glomerular Filtration Rate in Type 2 Diabetes Kidney & Blood Pressure Research Type 2 diabetes Diabetic kidney disease EGFR Interleukin-10 Polymorphism |
| title | Association of –1082A>G Polymorphism in the Interleukin-10 Gene with Estimated Glomerular Filtration Rate in Type 2 Diabetes |
| title_full | Association of –1082A>G Polymorphism in the Interleukin-10 Gene with Estimated Glomerular Filtration Rate in Type 2 Diabetes |
| title_fullStr | Association of –1082A>G Polymorphism in the Interleukin-10 Gene with Estimated Glomerular Filtration Rate in Type 2 Diabetes |
| title_full_unstemmed | Association of –1082A>G Polymorphism in the Interleukin-10 Gene with Estimated Glomerular Filtration Rate in Type 2 Diabetes |
| title_short | Association of –1082A>G Polymorphism in the Interleukin-10 Gene with Estimated Glomerular Filtration Rate in Type 2 Diabetes |
| title_sort | association of 1082a x3e g polymorphism in the interleukin 10 gene with estimated glomerular filtration rate in type 2 diabetes |
| topic | Type 2 diabetes Diabetic kidney disease EGFR Interleukin-10 Polymorphism |
| url | https://www.karger.com/Article/FullText/485863 |
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