A Translational Perspective of Maternal Immune Activation by SARS-CoV-2 on the Potential Prenatal Origin of Neurodevelopmental Disorders: The Role of the Cholinergic Anti-inflammatory Pathway
The emergent Coronavirus Disease 2019 (COVID-19) caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) could produce a maternal immune activation (MIA) via the inflammatory response during gestation that may impair fetal neurodevelopment and lead to postnatal and adulthood menta...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-03-01
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| Series: | Frontiers in Psychology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyg.2021.614451/full |
| _version_ | 1818933750168289280 |
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| author | José Javier Reyes-Lagos Eric Alonso Abarca-Castro Juan Carlos Echeverría Hugo Mendieta-Zerón Hugo Mendieta-Zerón Alejandra Vargas-Caraveo Gustavo Pacheco-López |
| author_facet | José Javier Reyes-Lagos Eric Alonso Abarca-Castro Juan Carlos Echeverría Hugo Mendieta-Zerón Hugo Mendieta-Zerón Alejandra Vargas-Caraveo Gustavo Pacheco-López |
| author_sort | José Javier Reyes-Lagos |
| collection | DOAJ |
| description | The emergent Coronavirus Disease 2019 (COVID-19) caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) could produce a maternal immune activation (MIA) via the inflammatory response during gestation that may impair fetal neurodevelopment and lead to postnatal and adulthood mental illness and behavioral dysfunctions. However, so far, limited evidence exists regarding long-term physiological, immunological, and neurodevelopmental modifications produced by the SARS-CoV-2 in the human maternal-fetal binomial and, particularly, in the offspring. Relevant findings derived from epidemiological and preclinical models show that a MIA is indeed linked to an increased risk of neurodevelopmental disorders in the offspring. We hypothesize that a gestational infection triggered by SARS-CoV-2 increases the risks leading to neurodevelopmental disorders of the newborn, which can affect childhood and the long-term quality of life. In particular, disruption of either the maternal or the fetal cholinergic anti-inflammatory pathway (CAP) could cause or exacerbate the severity of COVID-19 in the maternal-fetal binomial. From a translational perspective, in this paper, we discuss the possible manifestation of a MIA by SARS-CoV-2 and the subsequent neurodevelopmental disorders considering the role of the fetal-maternal cytokine cross-talk and the CAP. Specifically, we highlight the urgent need of preclinical studies as well as multicenter and international databanks of maternal-fetal psychophysiological data obtained pre-, during, and post-infection by SARS-CoV-2 from pregnant women and their offspring. |
| first_indexed | 2024-12-20T04:53:20Z |
| format | Article |
| id | doaj.art-9120f38f6c984bc9bba02775b55ad702 |
| institution | Directory Open Access Journal |
| issn | 1664-1078 |
| language | English |
| last_indexed | 2024-12-20T04:53:20Z |
| publishDate | 2021-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychology |
| spelling | doaj.art-9120f38f6c984bc9bba02775b55ad7022022-12-21T19:52:48ZengFrontiers Media S.A.Frontiers in Psychology1664-10782021-03-011210.3389/fpsyg.2021.614451614451A Translational Perspective of Maternal Immune Activation by SARS-CoV-2 on the Potential Prenatal Origin of Neurodevelopmental Disorders: The Role of the Cholinergic Anti-inflammatory PathwayJosé Javier Reyes-Lagos0Eric Alonso Abarca-Castro1Juan Carlos Echeverría2Hugo Mendieta-Zerón3Hugo Mendieta-Zerón4Alejandra Vargas-Caraveo5Gustavo Pacheco-López6Faculty of Medicine, Autonomous University of the State of Mexico (UAEMex), Toluca, MexicoMultidisciplinary Research Center in Education (CIME), Autonomous University of the State of Mexico (UAEMex), Toluca, MexicoBasic Sciences and Engineering Division, Campus Iztapalapa, Metropolitan Autonomous University (UAM), Mexico City, MexicoFaculty of Medicine, Autonomous University of the State of Mexico (UAEMex), Toluca, MexicoHealth Institute of the State of Mexico (ISEM), “Mónica Pretelini Sáenz” Maternal-Perinatal Hospital, Toluca, MexicoBiological and Health Sciences Division, Campus Lerma, Metropolitan Autonomous University (UAM), Lerma, MexicoBiological and Health Sciences Division, Campus Lerma, Metropolitan Autonomous University (UAM), Lerma, MexicoThe emergent Coronavirus Disease 2019 (COVID-19) caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) could produce a maternal immune activation (MIA) via the inflammatory response during gestation that may impair fetal neurodevelopment and lead to postnatal and adulthood mental illness and behavioral dysfunctions. However, so far, limited evidence exists regarding long-term physiological, immunological, and neurodevelopmental modifications produced by the SARS-CoV-2 in the human maternal-fetal binomial and, particularly, in the offspring. Relevant findings derived from epidemiological and preclinical models show that a MIA is indeed linked to an increased risk of neurodevelopmental disorders in the offspring. We hypothesize that a gestational infection triggered by SARS-CoV-2 increases the risks leading to neurodevelopmental disorders of the newborn, which can affect childhood and the long-term quality of life. In particular, disruption of either the maternal or the fetal cholinergic anti-inflammatory pathway (CAP) could cause or exacerbate the severity of COVID-19 in the maternal-fetal binomial. From a translational perspective, in this paper, we discuss the possible manifestation of a MIA by SARS-CoV-2 and the subsequent neurodevelopmental disorders considering the role of the fetal-maternal cytokine cross-talk and the CAP. Specifically, we highlight the urgent need of preclinical studies as well as multicenter and international databanks of maternal-fetal psychophysiological data obtained pre-, during, and post-infection by SARS-CoV-2 from pregnant women and their offspring.https://www.frontiersin.org/articles/10.3389/fpsyg.2021.614451/fullcholinergic anti-inflammatory pathwayquality of lifeCOVID-19neurodevelopmental disordershuman developmentheart rate variability |
| spellingShingle | José Javier Reyes-Lagos Eric Alonso Abarca-Castro Juan Carlos Echeverría Hugo Mendieta-Zerón Hugo Mendieta-Zerón Alejandra Vargas-Caraveo Gustavo Pacheco-López A Translational Perspective of Maternal Immune Activation by SARS-CoV-2 on the Potential Prenatal Origin of Neurodevelopmental Disorders: The Role of the Cholinergic Anti-inflammatory Pathway Frontiers in Psychology cholinergic anti-inflammatory pathway quality of life COVID-19 neurodevelopmental disorders human development heart rate variability |
| title | A Translational Perspective of Maternal Immune Activation by SARS-CoV-2 on the Potential Prenatal Origin of Neurodevelopmental Disorders: The Role of the Cholinergic Anti-inflammatory Pathway |
| title_full | A Translational Perspective of Maternal Immune Activation by SARS-CoV-2 on the Potential Prenatal Origin of Neurodevelopmental Disorders: The Role of the Cholinergic Anti-inflammatory Pathway |
| title_fullStr | A Translational Perspective of Maternal Immune Activation by SARS-CoV-2 on the Potential Prenatal Origin of Neurodevelopmental Disorders: The Role of the Cholinergic Anti-inflammatory Pathway |
| title_full_unstemmed | A Translational Perspective of Maternal Immune Activation by SARS-CoV-2 on the Potential Prenatal Origin of Neurodevelopmental Disorders: The Role of the Cholinergic Anti-inflammatory Pathway |
| title_short | A Translational Perspective of Maternal Immune Activation by SARS-CoV-2 on the Potential Prenatal Origin of Neurodevelopmental Disorders: The Role of the Cholinergic Anti-inflammatory Pathway |
| title_sort | translational perspective of maternal immune activation by sars cov 2 on the potential prenatal origin of neurodevelopmental disorders the role of the cholinergic anti inflammatory pathway |
| topic | cholinergic anti-inflammatory pathway quality of life COVID-19 neurodevelopmental disorders human development heart rate variability |
| url | https://www.frontiersin.org/articles/10.3389/fpsyg.2021.614451/full |
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