Rescue of altered HDAC activity recovers behavioural abnormalities in a mouse model of Angelman syndrome

Rescue of altered HDAC activity recovers behavioural abnormalities in a mouse model of Angelman syndrome

Angelman syndrome (AS) is a neurodevelopmental disorder characterized by severe intellectual and developmental disabilities. The disease is caused by the loss of function of maternally inherited UBE3A, a gene that exhibits paternal-specific imprinting in neuronal tissues. Ube3a-maternal deficient mi...

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Bibliographic Details
Main Authors: Imran Jamal, Vipendra Kumar, Naman Vatsa, Shashi Shekhar, Brijesh Kumar Singh, Ankit Sharma, Nihar Ranjan Jana
Format: Article
Language:English
Published: Elsevier 2017-09-01
Series:Neurobiology of Disease
Subjects:
Angelman syndrome
Ube3a
HDAC
Sodium valproate, HDAC inhibitor
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996117301225

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http://www.sciencedirect.com/science/article/pii/S0969996117301225

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