Alterations of DNA Methylation at GDNF Gene Promoter in the Ventral Tegmental Area of Adult Depression-Like Rats Induced by Maternal Deprivation

Alterations of DNA Methylation at GDNF Gene Promoter in the Ventral Tegmental Area of Adult Depression-Like Rats Induced by Maternal Deprivation

Objective: To study the expression and DNA methylation of the Glial cell line-derived neurotrophic factor (GDNF) gene in the development of depression-like behaviors in rats experiencing maternal deprivation stress in early life.Methods: Newborn SD rats were randomly assigned to a normal control gro...

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Bibliographic Details
Main Authors: Yi Zhang, Lei Wang, Xin Wang, Yuting Wang, Chuting Li, Xiongzhao Zhu
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-01-01
Series:Frontiers in Psychiatry
Subjects:
maternal deprivation
depression
GDNF
DNA methylation
ventral regimental area
Online Access:https://www.frontiersin.org/article/10.3389/fpsyt.2018.00732/full

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