Fractional Order Magnetic Resonance Fingerprinting in the Human Cerebral Cortex
Mathematical models are becoming increasingly important in magnetic resonance imaging (MRI), as they provide a mechanistic approach for making a link between tissue microstructure and signals acquired using the medical imaging instrument. The Bloch equations, which describes spin and relaxation in a...
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MDPI AG
2021-07-01
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| author | Viktor Vegh Shahrzad Moinian Qianqian Yang David C. Reutens |
| author_facet | Viktor Vegh Shahrzad Moinian Qianqian Yang David C. Reutens |
| author_sort | Viktor Vegh |
| collection | DOAJ |
| description | Mathematical models are becoming increasingly important in magnetic resonance imaging (MRI), as they provide a mechanistic approach for making a link between tissue microstructure and signals acquired using the medical imaging instrument. The Bloch equations, which describes spin and relaxation in a magnetic field, are a set of integer order differential equations with a solution exhibiting mono-exponential behaviour in time. Parameters of the model may be estimated using a non-linear solver or by creating a dictionary of model parameters from which MRI signals are simulated and then matched with experiment. We have previously shown the potential efficacy of a magnetic resonance fingerprinting (MRF) approach, i.e., dictionary matching based on the classical Bloch equations for parcellating the human cerebral cortex. However, this classical model is unable to describe in full the mm-scale MRI signal generated based on an heterogenous and complex tissue micro-environment. The time-fractional order Bloch equations have been shown to provide, as a function of time, a good fit of brain MRI signals. The time-fractional model has solutions in the form of Mittag–Leffler functions that generalise conventional exponential relaxation. Such functions have been shown by others to be useful for describing dielectric and viscoelastic relaxation in complex heterogeneous materials. Hence, we replaced the integer order Bloch equations with the previously reported time-fractional counterpart within the MRF framework and performed experiments to parcellate human gray matter, which consists of cortical brain tissue with different cyto-architecture at different spatial locations. Our findings suggest that the time-fractional order parameters, α and β, potentially associate with the effect of interareal architectonic variability, which hypothetically results in more accurate cortical parcellation. |
| first_indexed | 2024-03-10T09:50:57Z |
| format | Article |
| id | doaj.art-9124a1d0c75a4c7baa1c5e8859132695 |
| institution | Directory Open Access Journal |
| issn | 2227-7390 |
| language | English |
| last_indexed | 2024-03-10T09:50:57Z |
| publishDate | 2021-07-01 |
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| series | Mathematics |
| spelling | doaj.art-9124a1d0c75a4c7baa1c5e88591326952023-11-22T02:45:59ZengMDPI AGMathematics2227-73902021-07-01913154910.3390/math9131549Fractional Order Magnetic Resonance Fingerprinting in the Human Cerebral CortexViktor Vegh0Shahrzad Moinian1Qianqian Yang2David C. Reutens3Centre for Advanced Imaging, University of Queensland, Brisbane 4072, AustraliaCentre for Advanced Imaging, University of Queensland, Brisbane 4072, AustraliaSchool of Mathematical Sciences, Queensland University of Technology, Brisbane 4000, AustraliaCentre for Advanced Imaging, University of Queensland, Brisbane 4072, AustraliaMathematical models are becoming increasingly important in magnetic resonance imaging (MRI), as they provide a mechanistic approach for making a link between tissue microstructure and signals acquired using the medical imaging instrument. The Bloch equations, which describes spin and relaxation in a magnetic field, are a set of integer order differential equations with a solution exhibiting mono-exponential behaviour in time. Parameters of the model may be estimated using a non-linear solver or by creating a dictionary of model parameters from which MRI signals are simulated and then matched with experiment. We have previously shown the potential efficacy of a magnetic resonance fingerprinting (MRF) approach, i.e., dictionary matching based on the classical Bloch equations for parcellating the human cerebral cortex. However, this classical model is unable to describe in full the mm-scale MRI signal generated based on an heterogenous and complex tissue micro-environment. The time-fractional order Bloch equations have been shown to provide, as a function of time, a good fit of brain MRI signals. The time-fractional model has solutions in the form of Mittag–Leffler functions that generalise conventional exponential relaxation. Such functions have been shown by others to be useful for describing dielectric and viscoelastic relaxation in complex heterogeneous materials. Hence, we replaced the integer order Bloch equations with the previously reported time-fractional counterpart within the MRF framework and performed experiments to parcellate human gray matter, which consists of cortical brain tissue with different cyto-architecture at different spatial locations. Our findings suggest that the time-fractional order parameters, α and β, potentially associate with the effect of interareal architectonic variability, which hypothetically results in more accurate cortical parcellation.https://www.mdpi.com/2227-7390/9/13/1549anomalous relaxationmagnetic resonance imagingfractional calculuscortical parcellation |
| spellingShingle | Viktor Vegh Shahrzad Moinian Qianqian Yang David C. Reutens Fractional Order Magnetic Resonance Fingerprinting in the Human Cerebral Cortex Mathematics anomalous relaxation magnetic resonance imaging fractional calculus cortical parcellation |
| title | Fractional Order Magnetic Resonance Fingerprinting in the Human Cerebral Cortex |
| title_full | Fractional Order Magnetic Resonance Fingerprinting in the Human Cerebral Cortex |
| title_fullStr | Fractional Order Magnetic Resonance Fingerprinting in the Human Cerebral Cortex |
| title_full_unstemmed | Fractional Order Magnetic Resonance Fingerprinting in the Human Cerebral Cortex |
| title_short | Fractional Order Magnetic Resonance Fingerprinting in the Human Cerebral Cortex |
| title_sort | fractional order magnetic resonance fingerprinting in the human cerebral cortex |
| topic | anomalous relaxation magnetic resonance imaging fractional calculus cortical parcellation |
| url | https://www.mdpi.com/2227-7390/9/13/1549 |
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