Unilateral gonadoblastoma with dysgerminoma in normal fertile woman having a child: Extremely rare occurrence with characteristic immunohistomorphology
Gonadoblastomas (GBYs) are rare gonadal tumors almost always arising from a dysgenetic gonad with a Y chromosome. Very rarely, GBYs appear in otherwise normal women with a history of pregnancy. The typical histological appearance of GBY can be altered by extensive deposition of basement membrane mat...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2016-01-01
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| Series: | Indian Journal of Pathology and Microbiology |
| Subjects: | |
| Online Access: | http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2016;volume=59;issue=4;spage=527;epage=529;aulast=Kulkarni |
| _version_ | 1818027007656591360 |
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| author | Maithili Mandar Kulkarni Siddhi Gaurish Sinai Khandeparkar Avinash R Joshi Pallavi V Bhayekar |
| author_facet | Maithili Mandar Kulkarni Siddhi Gaurish Sinai Khandeparkar Avinash R Joshi Pallavi V Bhayekar |
| author_sort | Maithili Mandar Kulkarni |
| collection | DOAJ |
| description | Gonadoblastomas (GBYs) are rare gonadal tumors almost always arising from a dysgenetic gonad with a Y chromosome. Very rarely, GBYs appear in otherwise normal women with a history of pregnancy. The typical histological appearance of GBY can be altered by extensive deposition of basement membrane material, calcification, or overgrowth by a malignant tumor. Less than 10 cases have been reported with normal 46XX karyotype. Only six cases of GBY have been described in pregnant women. We present a unique case of GBY with dysgerminoma in a genotypically and phenotypically normal woman with a history of normal pregnancy, absence of virilization, and characteristic immunohistomorphological features. |
| first_indexed | 2024-12-10T04:41:03Z |
| format | Article |
| id | doaj.art-9129c61fcb834b8599c958c8f32f921e |
| institution | Directory Open Access Journal |
| issn | 0377-4929 |
| language | English |
| last_indexed | 2024-12-10T04:41:03Z |
| publishDate | 2016-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Pathology and Microbiology |
| spelling | doaj.art-9129c61fcb834b8599c958c8f32f921e2022-12-22T02:01:53ZengWolters Kluwer Medknow PublicationsIndian Journal of Pathology and Microbiology0377-49292016-01-0159452752910.4103/0377-4929.191815Unilateral gonadoblastoma with dysgerminoma in normal fertile woman having a child: Extremely rare occurrence with characteristic immunohistomorphologyMaithili Mandar KulkarniSiddhi Gaurish Sinai KhandeparkarAvinash R JoshiPallavi V BhayekarGonadoblastomas (GBYs) are rare gonadal tumors almost always arising from a dysgenetic gonad with a Y chromosome. Very rarely, GBYs appear in otherwise normal women with a history of pregnancy. The typical histological appearance of GBY can be altered by extensive deposition of basement membrane material, calcification, or overgrowth by a malignant tumor. Less than 10 cases have been reported with normal 46XX karyotype. Only six cases of GBY have been described in pregnant women. We present a unique case of GBY with dysgerminoma in a genotypically and phenotypically normal woman with a history of normal pregnancy, absence of virilization, and characteristic immunohistomorphological features.http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2016;volume=59;issue=4;spage=527;epage=529;aulast=KulkarniFertile womangonadoblastoma with dysgerminomagonadoblastoma with normal karyotype |
| spellingShingle | Maithili Mandar Kulkarni Siddhi Gaurish Sinai Khandeparkar Avinash R Joshi Pallavi V Bhayekar Unilateral gonadoblastoma with dysgerminoma in normal fertile woman having a child: Extremely rare occurrence with characteristic immunohistomorphology Indian Journal of Pathology and Microbiology Fertile woman gonadoblastoma with dysgerminoma gonadoblastoma with normal karyotype |
| title | Unilateral gonadoblastoma with dysgerminoma in normal fertile woman having a child: Extremely rare occurrence with characteristic immunohistomorphology |
| title_full | Unilateral gonadoblastoma with dysgerminoma in normal fertile woman having a child: Extremely rare occurrence with characteristic immunohistomorphology |
| title_fullStr | Unilateral gonadoblastoma with dysgerminoma in normal fertile woman having a child: Extremely rare occurrence with characteristic immunohistomorphology |
| title_full_unstemmed | Unilateral gonadoblastoma with dysgerminoma in normal fertile woman having a child: Extremely rare occurrence with characteristic immunohistomorphology |
| title_short | Unilateral gonadoblastoma with dysgerminoma in normal fertile woman having a child: Extremely rare occurrence with characteristic immunohistomorphology |
| title_sort | unilateral gonadoblastoma with dysgerminoma in normal fertile woman having a child extremely rare occurrence with characteristic immunohistomorphology |
| topic | Fertile woman gonadoblastoma with dysgerminoma gonadoblastoma with normal karyotype |
| url | http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2016;volume=59;issue=4;spage=527;epage=529;aulast=Kulkarni |
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