Roles for the 8-Oxoguanine DNA Repair System in Protecting Telomeres From Oxidative Stress

Roles for the 8-Oxoguanine DNA Repair System in Protecting Telomeres From Oxidative Stress

Telomeres are protective nucleoprotein structures that cap linear chromosome ends and safeguard genome stability. Progressive telomere shortening at each somatic cell division eventually leads to critically short and dysfunctional telomeres, which can contribute to either cellular senescence and agi...

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Bibliographic Details
Main Authors: Mariarosaria De Rosa, Samuel A. Johnson, Patricia L. Opresko
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-11-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
Telomeres
oxidative stress
8-oxoguanine
Base excision repair
Telomerase
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.758402/full

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