Impact of Dietary Fat on the Progression of Liver Fibrosis: Lessons from Animal and Cell Studies
Previous studies have revealed that a high-fat diet is one of the key contributors to the progression of liver fibrosis, and increasing studies are devoted to analyzing the different influences of diverse fat sources on the progression of non-alcoholic steatohepatitis. When we treated three types of...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-09-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/19/10303 |
| _version_ | 1797516350863704064 |
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| author | Fangping Jia Xiao Hu Takefumi Kimura Naoki Tanaka |
| author_facet | Fangping Jia Xiao Hu Takefumi Kimura Naoki Tanaka |
| author_sort | Fangping Jia |
| collection | DOAJ |
| description | Previous studies have revealed that a high-fat diet is one of the key contributors to the progression of liver fibrosis, and increasing studies are devoted to analyzing the different influences of diverse fat sources on the progression of non-alcoholic steatohepatitis. When we treated three types of isocaloric diets that are rich in cholesterol, saturated fatty acid (SFA) and trans fatty acid (TFA) with hepatitis C virus core gene transgenic mice that spontaneously developed hepatic steatosis without apparent fibrosis, TFA and cholesterol-rich diet, but not SFA-rich diet, displayed distinct hepatic fibrosis. This review summarizes the recent advances in animal and cell studies regarding the effects of these three types of fat on liver fibrogenesis. |
| first_indexed | 2024-03-10T07:00:01Z |
| format | Article |
| id | doaj.art-912a66b9e94b48c5bce0d4d904cc49f7 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T07:00:01Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-912a66b9e94b48c5bce0d4d904cc49f72023-11-22T16:07:29ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-09-0122191030310.3390/ijms221910303Impact of Dietary Fat on the Progression of Liver Fibrosis: Lessons from Animal and Cell StudiesFangping Jia0Xiao Hu1Takefumi Kimura2Naoki Tanaka3Department of Metabolic Regulation, Shinshu University School of Medicine, Matsumoto 390-8621, JapanDepartment of Pathophysiology, Hebei Medical University, Shijiazhuang 050017, ChinaDepartment of Gastroenterology, Shinshu University School of Medicine, Matsumoto 390-8621, JapanDepartment of Metabolic Regulation, Shinshu University School of Medicine, Matsumoto 390-8621, JapanPrevious studies have revealed that a high-fat diet is one of the key contributors to the progression of liver fibrosis, and increasing studies are devoted to analyzing the different influences of diverse fat sources on the progression of non-alcoholic steatohepatitis. When we treated three types of isocaloric diets that are rich in cholesterol, saturated fatty acid (SFA) and trans fatty acid (TFA) with hepatitis C virus core gene transgenic mice that spontaneously developed hepatic steatosis without apparent fibrosis, TFA and cholesterol-rich diet, but not SFA-rich diet, displayed distinct hepatic fibrosis. This review summarizes the recent advances in animal and cell studies regarding the effects of these three types of fat on liver fibrogenesis.https://www.mdpi.com/1422-0067/22/19/10303fatty liverNASHdietary fatcholesterolsaturated fatty acidtrans fatty acid |
| spellingShingle | Fangping Jia Xiao Hu Takefumi Kimura Naoki Tanaka Impact of Dietary Fat on the Progression of Liver Fibrosis: Lessons from Animal and Cell Studies International Journal of Molecular Sciences fatty liver NASH dietary fat cholesterol saturated fatty acid trans fatty acid |
| title | Impact of Dietary Fat on the Progression of Liver Fibrosis: Lessons from Animal and Cell Studies |
| title_full | Impact of Dietary Fat on the Progression of Liver Fibrosis: Lessons from Animal and Cell Studies |
| title_fullStr | Impact of Dietary Fat on the Progression of Liver Fibrosis: Lessons from Animal and Cell Studies |
| title_full_unstemmed | Impact of Dietary Fat on the Progression of Liver Fibrosis: Lessons from Animal and Cell Studies |
| title_short | Impact of Dietary Fat on the Progression of Liver Fibrosis: Lessons from Animal and Cell Studies |
| title_sort | impact of dietary fat on the progression of liver fibrosis lessons from animal and cell studies |
| topic | fatty liver NASH dietary fat cholesterol saturated fatty acid trans fatty acid |
| url | https://www.mdpi.com/1422-0067/22/19/10303 |
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