The Therapeutic Effects of West Indian Elm (Guazuma ulmifolia) Leaf Extract on Coronary Artery Atherosclerosis in Hypercholesterolemic Wistar Rats
This study aimed to determine the therapeutic effect of West Indian elm leaf extract on coronary artery atherosclerosis in hypercholesterolemia Wistar rats. Cholesterol, a key factor in the pathophysiology of coronary heart disease, is present in fat-containing diets. Orlistat is one of the medicati...
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| Format: | Article |
| Language: | English |
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Bogor Agricultural University
2023-07-01
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| Series: | Jurnal Gizi dan Pangan |
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| Online Access: | https://jurnal.ipb.ac.id/index.php/jgizipangan/article/view/45088 |
| _version_ | 1797672566126542848 |
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| author | Reza Ramadhansyah Maria Selvester Thadeus Hikmah Muktamiroh Niniek Hardini |
| author_facet | Reza Ramadhansyah Maria Selvester Thadeus Hikmah Muktamiroh Niniek Hardini |
| author_sort | Reza Ramadhansyah |
| collection | DOAJ |
| description | This study aimed to determine the therapeutic effect of West Indian elm leaf extract on coronary artery atherosclerosis in hypercholesterolemia Wistar rats. Cholesterol, a key factor in the pathophysiology of coronary heart disease, is present in fat-containing diets. Orlistat is one of the medications that can reduce blood cholesterol levels, but since it has side effects, herbs are more preferable to it. One such herbal plant, West Indian elm (Guazuma ulmifolia), contains tannins, saponins, alkaloids, and flavonoids, secondary metabolites that carry the properties necessary to reduce blood cholesterol levels, in its leaves. In this experimental study, which focused on histopathological parameters to see the scale of progression of coronary artery atherosclerosis, 30 Wistar rats were induced with a high-fat diet and divided into 6 sample groups, consisting of three control groups (normal, negative, and positive) and three treatment groups (which received a West Indian elm leaf extract at 0.2, 0.4, and 0.8 g/kgBW). Significant results were obtained from both Kruskal-Wallis and Mann-Whitney tests (p<0.05) between the negative control group and the positive control group, between the negative control group and treatment group 2 (0.4 g/kgBW), and between the negative control group and treatment group 3 (0.8 g/kgBW). In conclusion, this study proved that West Indian elm (Guazuma ulmifolia) leaf extract reduces the development of coronary atherosclerosis and shares a similarity in therapeutic effect with orlistat.
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| first_indexed | 2024-03-11T21:31:55Z |
| format | Article |
| id | doaj.art-912be44025454c628f1b85c22239a872 |
| institution | Directory Open Access Journal |
| issn | 1978-1059 2407-0920 |
| language | English |
| last_indexed | 2024-03-11T21:31:55Z |
| publishDate | 2023-07-01 |
| publisher | Bogor Agricultural University |
| record_format | Article |
| series | Jurnal Gizi dan Pangan |
| spelling | doaj.art-912be44025454c628f1b85c22239a8722023-09-27T08:28:45ZengBogor Agricultural UniversityJurnal Gizi dan Pangan1978-10592407-09202023-07-0118210.25182/jgp.2023.18.2.109-116The Therapeutic Effects of West Indian Elm (Guazuma ulmifolia) Leaf Extract on Coronary Artery Atherosclerosis in Hypercholesterolemic Wistar RatsReza Ramadhansyah0Maria Selvester Thadeus1Hikmah Muktamiroh2Niniek Hardini3Departement of Anatomical Pathology, Faculty of Medicine, “Veteran” National Development University of Jakarta, South Jakarta 12450, IndonesiaDepartement of Anatomical Pathology, Faculty of Medicine, “Veteran” National Development University of Jakarta, South Jakarta 12450, IndonesiaDepartment of Medical Education, Faculty of Medicine, “Veteran” National Development University of Jakarta, South Jakarta 12450, IndonesiaDepartement of Anatomical Pathology, Faculty of Medicine, “Veteran” National Development University of Jakarta, South Jakarta 12450, IndonesiaThis study aimed to determine the therapeutic effect of West Indian elm leaf extract on coronary artery atherosclerosis in hypercholesterolemia Wistar rats. Cholesterol, a key factor in the pathophysiology of coronary heart disease, is present in fat-containing diets. Orlistat is one of the medications that can reduce blood cholesterol levels, but since it has side effects, herbs are more preferable to it. One such herbal plant, West Indian elm (Guazuma ulmifolia), contains tannins, saponins, alkaloids, and flavonoids, secondary metabolites that carry the properties necessary to reduce blood cholesterol levels, in its leaves. In this experimental study, which focused on histopathological parameters to see the scale of progression of coronary artery atherosclerosis, 30 Wistar rats were induced with a high-fat diet and divided into 6 sample groups, consisting of three control groups (normal, negative, and positive) and three treatment groups (which received a West Indian elm leaf extract at 0.2, 0.4, and 0.8 g/kgBW). Significant results were obtained from both Kruskal-Wallis and Mann-Whitney tests (p<0.05) between the negative control group and the positive control group, between the negative control group and treatment group 2 (0.4 g/kgBW), and between the negative control group and treatment group 3 (0.8 g/kgBW). In conclusion, this study proved that West Indian elm (Guazuma ulmifolia) leaf extract reduces the development of coronary atherosclerosis and shares a similarity in therapeutic effect with orlistat. https://jurnal.ipb.ac.id/index.php/jgizipangan/article/view/45088atherosclerosishistopathologyorlistatwest indian elm leaf |
| spellingShingle | Reza Ramadhansyah Maria Selvester Thadeus Hikmah Muktamiroh Niniek Hardini The Therapeutic Effects of West Indian Elm (Guazuma ulmifolia) Leaf Extract on Coronary Artery Atherosclerosis in Hypercholesterolemic Wistar Rats Jurnal Gizi dan Pangan atherosclerosis histopathology orlistat west indian elm leaf |
| title | The Therapeutic Effects of West Indian Elm (Guazuma ulmifolia) Leaf Extract on Coronary Artery Atherosclerosis in Hypercholesterolemic Wistar Rats |
| title_full | The Therapeutic Effects of West Indian Elm (Guazuma ulmifolia) Leaf Extract on Coronary Artery Atherosclerosis in Hypercholesterolemic Wistar Rats |
| title_fullStr | The Therapeutic Effects of West Indian Elm (Guazuma ulmifolia) Leaf Extract on Coronary Artery Atherosclerosis in Hypercholesterolemic Wistar Rats |
| title_full_unstemmed | The Therapeutic Effects of West Indian Elm (Guazuma ulmifolia) Leaf Extract on Coronary Artery Atherosclerosis in Hypercholesterolemic Wistar Rats |
| title_short | The Therapeutic Effects of West Indian Elm (Guazuma ulmifolia) Leaf Extract on Coronary Artery Atherosclerosis in Hypercholesterolemic Wistar Rats |
| title_sort | therapeutic effects of west indian elm guazuma ulmifolia leaf extract on coronary artery atherosclerosis in hypercholesterolemic wistar rats |
| topic | atherosclerosis histopathology orlistat west indian elm leaf |
| url | https://jurnal.ipb.ac.id/index.php/jgizipangan/article/view/45088 |
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