A Genome-Wide Search for Candidate Genes of Meat Production in Jalgin Merino Considering Known Productivity Genes
In a group of Jalgin merino rams with no significant influence on the dispersion of the phenotypes of known productivity genes (<i>MSTN</i>, <i>MEF2B</i>, <i>FABP4</i>, etc.), a genome-wide search for associations of individual polymorphisms with intravital indica...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-07-01
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| Series: | Genes |
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| Online Access: | https://www.mdpi.com/2073-4425/13/8/1337 |
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| author | Alexander Krivoruchko Alexander Surov Antonina Skokova Anastasiya Kanibolotskaya Tatiana Saprikina Maxim Kukharuk Olesya Yatsyk |
| author_facet | Alexander Krivoruchko Alexander Surov Antonina Skokova Anastasiya Kanibolotskaya Tatiana Saprikina Maxim Kukharuk Olesya Yatsyk |
| author_sort | Alexander Krivoruchko |
| collection | DOAJ |
| description | In a group of Jalgin merino rams with no significant influence on the dispersion of the phenotypes of known productivity genes (<i>MSTN</i>, <i>MEF2B</i>, <i>FABP4</i>, etc.), a genome-wide search for associations of individual polymorphisms with intravital indicators of meat productivity was performed. Using the Ovine Infinium HD BeadChip 600K, 606,000 genome loci were evaluated. Twenty-three substitutions were found to be significantly associated with external measurements of the body and ultrasonic parameters. This made it possible to describe 14 candidate genes, the structural features of which can cause changes in animal phenotypes. No closely spaced genes were found for two substitutions. The identified polymorphisms were found in the exons, introns, and adjacent regions of the following genes and transcripts: <i>CDCA2</i>, <i>ENSOARG00000014477</i>, <i>C4BPA</i>, <i>RIPOR2</i>, <i>ENSOARG00000007198</i>, <i>ENSOARG00000026965 (LincRNA)</i>, <i>ENSOARG00000026436 (LincRNA)</i>, <i>ENSOARG00000026782 (LincRNA)</i>, <i>TENM3</i>, <i>RTL8A</i>, <i>MOSPD1</i>, <i>RTL8C</i>, <i>RIMS2</i>, and <i>P4HA3</i>. The detected genes affect the metabolic pathways of cell differentiation and proliferation and are associated with the regulation of the immune system. This confirms their possible participation in the formation of the phenotypes of productivity parameters in animals and indicates the need for further study of the structure of candidate genes in order to identify their internal polymorphisms. |
| first_indexed | 2024-03-09T04:25:00Z |
| format | Article |
| id | doaj.art-912c24dca38a49c8a29a642081cb48ca |
| institution | Directory Open Access Journal |
| issn | 2073-4425 |
| language | English |
| last_indexed | 2024-03-09T04:25:00Z |
| publishDate | 2022-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Genes |
| spelling | doaj.art-912c24dca38a49c8a29a642081cb48ca2023-12-03T13:42:36ZengMDPI AGGenes2073-44252022-07-01138133710.3390/genes13081337A Genome-Wide Search for Candidate Genes of Meat Production in Jalgin Merino Considering Known Productivity GenesAlexander Krivoruchko0Alexander Surov1Antonina Skokova2Anastasiya Kanibolotskaya3Tatiana Saprikina4Maxim Kukharuk5Olesya Yatsyk6FSBSI North Caucasian Federal Scientific Agrarian Center, 356241 Mikhailovsk, RussiaFSBSI North Caucasian Federal Scientific Agrarian Center, 356241 Mikhailovsk, RussiaFSBSI North Caucasian Federal Scientific Agrarian Center, 356241 Mikhailovsk, RussiaFSBSI North Caucasian Federal Scientific Agrarian Center, 356241 Mikhailovsk, RussiaFSBSI North Caucasian Federal Scientific Agrarian Center, 356241 Mikhailovsk, RussiaFederal State Autonomous Educational Institution of Higher Education, North Caucasian Federal University, 355017 Stavropol, RussiaFSBSI North Caucasian Federal Scientific Agrarian Center, 356241 Mikhailovsk, RussiaIn a group of Jalgin merino rams with no significant influence on the dispersion of the phenotypes of known productivity genes (<i>MSTN</i>, <i>MEF2B</i>, <i>FABP4</i>, etc.), a genome-wide search for associations of individual polymorphisms with intravital indicators of meat productivity was performed. Using the Ovine Infinium HD BeadChip 600K, 606,000 genome loci were evaluated. Twenty-three substitutions were found to be significantly associated with external measurements of the body and ultrasonic parameters. This made it possible to describe 14 candidate genes, the structural features of which can cause changes in animal phenotypes. No closely spaced genes were found for two substitutions. The identified polymorphisms were found in the exons, introns, and adjacent regions of the following genes and transcripts: <i>CDCA2</i>, <i>ENSOARG00000014477</i>, <i>C4BPA</i>, <i>RIPOR2</i>, <i>ENSOARG00000007198</i>, <i>ENSOARG00000026965 (LincRNA)</i>, <i>ENSOARG00000026436 (LincRNA)</i>, <i>ENSOARG00000026782 (LincRNA)</i>, <i>TENM3</i>, <i>RTL8A</i>, <i>MOSPD1</i>, <i>RTL8C</i>, <i>RIMS2</i>, and <i>P4HA3</i>. The detected genes affect the metabolic pathways of cell differentiation and proliferation and are associated with the regulation of the immune system. This confirms their possible participation in the formation of the phenotypes of productivity parameters in animals and indicates the need for further study of the structure of candidate genes in order to identify their internal polymorphisms.https://www.mdpi.com/2073-4425/13/8/1337sheepSNPgenome-wide association searchGWAScandidate geneJalgin merino |
| spellingShingle | Alexander Krivoruchko Alexander Surov Antonina Skokova Anastasiya Kanibolotskaya Tatiana Saprikina Maxim Kukharuk Olesya Yatsyk A Genome-Wide Search for Candidate Genes of Meat Production in Jalgin Merino Considering Known Productivity Genes Genes sheep SNP genome-wide association search GWAS candidate gene Jalgin merino |
| title | A Genome-Wide Search for Candidate Genes of Meat Production in Jalgin Merino Considering Known Productivity Genes |
| title_full | A Genome-Wide Search for Candidate Genes of Meat Production in Jalgin Merino Considering Known Productivity Genes |
| title_fullStr | A Genome-Wide Search for Candidate Genes of Meat Production in Jalgin Merino Considering Known Productivity Genes |
| title_full_unstemmed | A Genome-Wide Search for Candidate Genes of Meat Production in Jalgin Merino Considering Known Productivity Genes |
| title_short | A Genome-Wide Search for Candidate Genes of Meat Production in Jalgin Merino Considering Known Productivity Genes |
| title_sort | genome wide search for candidate genes of meat production in jalgin merino considering known productivity genes |
| topic | sheep SNP genome-wide association search GWAS candidate gene Jalgin merino |
| url | https://www.mdpi.com/2073-4425/13/8/1337 |
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