Slipped-strand mispairing within a polycytidine tract in transcriptional regulator mga leads to M protein phase variation and Mga length polymorphism in Group A Streptococcus

Slipped-strand mispairing within a polycytidine tract in transcriptional regulator mga leads to M protein phase variation and Mga length polymorphism in Group A Streptococcus

The M protein, a major virulence factor of Group A Streptococcus (GAS), is regulated by the multigene regulator Mga. An unexplained phenomena frequently occurring with in vitro genetic manipulation or culturing of M1T1 GAS strains is the loss of M protein production. This study was aimed at elucidat...

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Bibliographic Details
Main Authors: Benfang Lei, Tracey S. Hanks, Yunjuan Bao, Mengyao Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-06-01
Series:Frontiers in Microbiology
Subjects:
Group A Streptococcus
Streptococcus pyogenes
M protein
Mga
phase variation
slipped-strand mispairing
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2023.1212149/full

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