A Novel C Type CpG Oligodeoxynucleotide Exhibits Immunostimulatory Activity In Vitro and Enhances Antitumor Effect In Vivo

A Novel C Type CpG Oligodeoxynucleotide Exhibits Immunostimulatory Activity In Vitro and Enhances Antitumor Effect In Vivo

BackgroundC type CpG oligodeoxynucleotides (CpG-C ODNs), possessing the features of both A type and B type CpG ODNs, exert a variety of immunostimulatory activities and have been demonstrated as an effective antitumor immunotherapy. Based on the structural characteristics, we designed 20 potential O...

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Bibliographic Details
Main Authors: Tete Li, Jing Wu, Shan Zhu, Guoxia Zang, Shuang Li, Xinping Lv, Wenjun Yue, Yuan Qiao, Jiuwei Cui, Yan Shao, Jun Zhang, Yong-Jun Liu, Jingtao Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-02-01
Series:Frontiers in Pharmacology
Subjects:
cytosine-phosphate-guanosine dinucleotide-containing oligodeoxynucleotides
Toll-like receptor 9
plasmacytoid dendritic cells
B cells
antitumor immunotherapy
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.00008/full

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