Pulmonary Functional Imaging for Lung Adenocarcinoma: Combined MRI Assessment Based on IVIM-DWI and OE-UTE-MRI
PurposeThe goal of current study was to introduce noninvasive and reproducible MRI methods for in vivo functional assessment of lung adenocarcinoma (LUAD).MethodsForty-four patients with pathologically confirmed LUAD were included in this study. All the lesions were classified as adenocarcinoma in s...
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2021-07-01
|
| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2021.677942/full |
| _version_ | 1818672432371728384 |
|---|---|
| author | Hui Liu Liyun Zheng Gaofeng Shi Qian Xu Qi Wang Hongshan Zhu Hui Feng Lijia Wang Ning Zhang Meng Xue Yongming Dai |
| author_facet | Hui Liu Liyun Zheng Gaofeng Shi Qian Xu Qi Wang Hongshan Zhu Hui Feng Lijia Wang Ning Zhang Meng Xue Yongming Dai |
| author_sort | Hui Liu |
| collection | DOAJ |
| description | PurposeThe goal of current study was to introduce noninvasive and reproducible MRI methods for in vivo functional assessment of lung adenocarcinoma (LUAD).MethodsForty-four patients with pathologically confirmed LUAD were included in this study. All the lesions were classified as adenocarcinoma in situ (AIS), minimally invasive adenocarcinoma (MIA), or invasive adenocarcinoma (IA). The IA lesions were further divided into five subtype patterns, including acinar, lepidic, papillary, micropapillary and solid. Tumors were grouped depending on predominant subtype: low grade (AIS, MIA or lepidic predominant), intermediate grade (papillary or acinar predominant) and high grade (micropapillary, or solid predominant). Spirometry was performed according to American Thoracic Society guidelines. For each patient, Intravoxel incoherent motion diffusion weighted imaging (IVIM-DWI) analysis and oxygen-enhanced MRI (OE-MRI) analysis were performed. Spearman’s test was used to assess the relationship between a) whole lung mean percent signal enhancement (PSE) and pulmonary function tests (PFTs) parameters; b) IVIM-derived parameters and PFTs parameters; c) tumor mean PSE and IVIM-derived parameters. Kruskal -Wallis tests were applied to test the difference of tumor mean PSE and IVIM-derived parameters between different histological tumor grades. Receiver operating characteristics (ROC) analysis was used to evaluate the diagnostic performance.ResultsWhole lung mean PSE was significantly positively correlated with PFTs parameters (r = 0.40 ~ 0.44, P < 0.05). f value derived from IVIM-DWI was significantly negatively correlated with PFTs parameters (r = -0.38 ~ -0.47, P < 0.05). Both tumor mean PSE (P = 0.030 < 0.05) and f (P = 0.022 < 0.05) could differentiate different histological grades. f was negatively correlated with tumor mean PSE (r = -0.61, P < 0.001). For the diagnostic performance, the combination of tumor mean PSE and f outperformed than using tumor mean PSE or f alone in both sensitivity and area under the ROC curve.ConclusionsThe combined measurement of OE-MRI and IVIM-DWI may serve as a promising method for the noninvasive and non-radiation evaluation of pulmonary function. Quantitative analyses achieved by OE-MRI and IVIM-DWI offer an approach of the classification of LUAD subtypes. |
| first_indexed | 2024-12-17T07:39:48Z |
| format | Article |
| id | doaj.art-9130ee36ead14af0aa5144ca51248704 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-17T07:39:48Z |
| publishDate | 2021-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-9130ee36ead14af0aa5144ca512487042022-12-21T21:58:11ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2021-07-011110.3389/fonc.2021.677942677942Pulmonary Functional Imaging for Lung Adenocarcinoma: Combined MRI Assessment Based on IVIM-DWI and OE-UTE-MRIHui Liu0Liyun Zheng1Gaofeng Shi2Qian Xu3Qi Wang4Hongshan Zhu5Hui Feng6Lijia Wang7Ning Zhang8Meng Xue9Yongming Dai10Department of Radiology, Fourth Hospital of Hebei Medical University, Shijiazhuang, ChinaMR Collaboration, Central Research Institute, United Imaging Healthcare, Shanghai, ChinaDepartment of Radiology, Fourth Hospital of Hebei Medical University, Shijiazhuang, ChinaDepartment of Radiology, Fourth Hospital of Hebei Medical University, Shijiazhuang, ChinaDepartment of Radiology, Fourth Hospital of Hebei Medical University, Shijiazhuang, ChinaDepartment of Radiology, Fourth Hospital of Hebei Medical University, Shijiazhuang, ChinaDepartment of Radiology, Fourth Hospital of Hebei Medical University, Shijiazhuang, ChinaDepartment of Radiology, Fourth Hospital of Hebei Medical University, Shijiazhuang, ChinaDepartment of Radiology, Fourth Hospital of Hebei Medical University, Shijiazhuang, ChinaDepartment of Radiology, Fourth Hospital of Hebei Medical University, Shijiazhuang, ChinaMR Collaboration, Central Research Institute, United Imaging Healthcare, Shanghai, ChinaPurposeThe goal of current study was to introduce noninvasive and reproducible MRI methods for in vivo functional assessment of lung adenocarcinoma (LUAD).MethodsForty-four patients with pathologically confirmed LUAD were included in this study. All the lesions were classified as adenocarcinoma in situ (AIS), minimally invasive adenocarcinoma (MIA), or invasive adenocarcinoma (IA). The IA lesions were further divided into five subtype patterns, including acinar, lepidic, papillary, micropapillary and solid. Tumors were grouped depending on predominant subtype: low grade (AIS, MIA or lepidic predominant), intermediate grade (papillary or acinar predominant) and high grade (micropapillary, or solid predominant). Spirometry was performed according to American Thoracic Society guidelines. For each patient, Intravoxel incoherent motion diffusion weighted imaging (IVIM-DWI) analysis and oxygen-enhanced MRI (OE-MRI) analysis were performed. Spearman’s test was used to assess the relationship between a) whole lung mean percent signal enhancement (PSE) and pulmonary function tests (PFTs) parameters; b) IVIM-derived parameters and PFTs parameters; c) tumor mean PSE and IVIM-derived parameters. Kruskal -Wallis tests were applied to test the difference of tumor mean PSE and IVIM-derived parameters between different histological tumor grades. Receiver operating characteristics (ROC) analysis was used to evaluate the diagnostic performance.ResultsWhole lung mean PSE was significantly positively correlated with PFTs parameters (r = 0.40 ~ 0.44, P < 0.05). f value derived from IVIM-DWI was significantly negatively correlated with PFTs parameters (r = -0.38 ~ -0.47, P < 0.05). Both tumor mean PSE (P = 0.030 < 0.05) and f (P = 0.022 < 0.05) could differentiate different histological grades. f was negatively correlated with tumor mean PSE (r = -0.61, P < 0.001). For the diagnostic performance, the combination of tumor mean PSE and f outperformed than using tumor mean PSE or f alone in both sensitivity and area under the ROC curve.ConclusionsThe combined measurement of OE-MRI and IVIM-DWI may serve as a promising method for the noninvasive and non-radiation evaluation of pulmonary function. Quantitative analyses achieved by OE-MRI and IVIM-DWI offer an approach of the classification of LUAD subtypes.https://www.frontiersin.org/articles/10.3389/fonc.2021.677942/fullUTEIVIMOE-MRINSCLClung adenocarcinoma |
| spellingShingle | Hui Liu Liyun Zheng Gaofeng Shi Qian Xu Qi Wang Hongshan Zhu Hui Feng Lijia Wang Ning Zhang Meng Xue Yongming Dai Pulmonary Functional Imaging for Lung Adenocarcinoma: Combined MRI Assessment Based on IVIM-DWI and OE-UTE-MRI Frontiers in Oncology UTE IVIM OE-MRI NSCLC lung adenocarcinoma |
| title | Pulmonary Functional Imaging for Lung Adenocarcinoma: Combined MRI Assessment Based on IVIM-DWI and OE-UTE-MRI |
| title_full | Pulmonary Functional Imaging for Lung Adenocarcinoma: Combined MRI Assessment Based on IVIM-DWI and OE-UTE-MRI |
| title_fullStr | Pulmonary Functional Imaging for Lung Adenocarcinoma: Combined MRI Assessment Based on IVIM-DWI and OE-UTE-MRI |
| title_full_unstemmed | Pulmonary Functional Imaging for Lung Adenocarcinoma: Combined MRI Assessment Based on IVIM-DWI and OE-UTE-MRI |
| title_short | Pulmonary Functional Imaging for Lung Adenocarcinoma: Combined MRI Assessment Based on IVIM-DWI and OE-UTE-MRI |
| title_sort | pulmonary functional imaging for lung adenocarcinoma combined mri assessment based on ivim dwi and oe ute mri |
| topic | UTE IVIM OE-MRI NSCLC lung adenocarcinoma |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2021.677942/full |
| work_keys_str_mv | AT huiliu pulmonaryfunctionalimagingforlungadenocarcinomacombinedmriassessmentbasedonivimdwiandoeutemri AT liyunzheng pulmonaryfunctionalimagingforlungadenocarcinomacombinedmriassessmentbasedonivimdwiandoeutemri AT gaofengshi pulmonaryfunctionalimagingforlungadenocarcinomacombinedmriassessmentbasedonivimdwiandoeutemri AT qianxu pulmonaryfunctionalimagingforlungadenocarcinomacombinedmriassessmentbasedonivimdwiandoeutemri AT qiwang pulmonaryfunctionalimagingforlungadenocarcinomacombinedmriassessmentbasedonivimdwiandoeutemri AT hongshanzhu pulmonaryfunctionalimagingforlungadenocarcinomacombinedmriassessmentbasedonivimdwiandoeutemri AT huifeng pulmonaryfunctionalimagingforlungadenocarcinomacombinedmriassessmentbasedonivimdwiandoeutemri AT lijiawang pulmonaryfunctionalimagingforlungadenocarcinomacombinedmriassessmentbasedonivimdwiandoeutemri AT ningzhang pulmonaryfunctionalimagingforlungadenocarcinomacombinedmriassessmentbasedonivimdwiandoeutemri AT mengxue pulmonaryfunctionalimagingforlungadenocarcinomacombinedmriassessmentbasedonivimdwiandoeutemri AT yongmingdai pulmonaryfunctionalimagingforlungadenocarcinomacombinedmriassessmentbasedonivimdwiandoeutemri |