Diverse Resistant Mechanisms Identified Using Serial Next-Generation Sequencing in a Patient With ALK-Rearranged Metastatic Lung Adenocarcinoma: A Case Report
Both tissue and plasma-based next generation sequencing (NGS) facilitate the identification of actionable oncogene alterations at diagnosis and resistant mechanisms on progression. The value of longitudinal profiling is less established among patients with ALK-rearranged NSCLC, underpinned by concer...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-06-01
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| Series: | JTO Clinical and Research Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666364323000516 |
| _version_ | 1797795254458384384 |
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| author | Stephanie Pei Li Saw, MRCP Darren Wan-Teck Lim, MRCP |
| author_facet | Stephanie Pei Li Saw, MRCP Darren Wan-Teck Lim, MRCP |
| author_sort | Stephanie Pei Li Saw, MRCP |
| collection | DOAJ |
| description | Both tissue and plasma-based next generation sequencing (NGS) facilitate the identification of actionable oncogene alterations at diagnosis and resistant mechanisms on progression. The value of longitudinal profiling is less established among patients with ALK-rearranged NSCLC, underpinned by concerns of limited treatment options post-progression and assay sensitivity. We report a case of a patient with ALK-rearranged NSCLC with serial tissue and plasma NGS performed post-progression, whose results helped to guide sequencing of treatment options leading to an overall survival exceeding 8 years from diagnosis of metastatic disease. |
| first_indexed | 2024-03-13T03:15:09Z |
| format | Article |
| id | doaj.art-9131cf6902704589975b0d63fb756176 |
| institution | Directory Open Access Journal |
| issn | 2666-3643 |
| language | English |
| last_indexed | 2024-03-13T03:15:09Z |
| publishDate | 2023-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | JTO Clinical and Research Reports |
| spelling | doaj.art-9131cf6902704589975b0d63fb7561762023-06-26T04:14:51ZengElsevierJTO Clinical and Research Reports2666-36432023-06-0146100512Diverse Resistant Mechanisms Identified Using Serial Next-Generation Sequencing in a Patient With ALK-Rearranged Metastatic Lung Adenocarcinoma: A Case ReportStephanie Pei Li Saw, MRCP0Darren Wan-Teck Lim, MRCP1Corresponding author. Address for correspondence: Stephanie Pei Li Saw, MRCP, Division of Medical Oncology, National Cancer Centre Singapore, 30 Hospital Boulevard, Singapore 168583.; Division of Medical Oncology, National Cancer Centre, Singapore; Duke-NUS Medical School, National University of Singapore, SingaporeDivision of Medical Oncology, National Cancer Centre, Singapore; Duke-NUS Medical School, National University of Singapore, SingaporeBoth tissue and plasma-based next generation sequencing (NGS) facilitate the identification of actionable oncogene alterations at diagnosis and resistant mechanisms on progression. The value of longitudinal profiling is less established among patients with ALK-rearranged NSCLC, underpinned by concerns of limited treatment options post-progression and assay sensitivity. We report a case of a patient with ALK-rearranged NSCLC with serial tissue and plasma NGS performed post-progression, whose results helped to guide sequencing of treatment options leading to an overall survival exceeding 8 years from diagnosis of metastatic disease.http://www.sciencedirect.com/science/article/pii/S2666364323000516ALKNext-generation sequencingResistant mechanismsNon–small cell lung cancerCase report |
| spellingShingle | Stephanie Pei Li Saw, MRCP Darren Wan-Teck Lim, MRCP Diverse Resistant Mechanisms Identified Using Serial Next-Generation Sequencing in a Patient With ALK-Rearranged Metastatic Lung Adenocarcinoma: A Case Report JTO Clinical and Research Reports ALK Next-generation sequencing Resistant mechanisms Non–small cell lung cancer Case report |
| title | Diverse Resistant Mechanisms Identified Using Serial Next-Generation Sequencing in a Patient With ALK-Rearranged Metastatic Lung Adenocarcinoma: A Case Report |
| title_full | Diverse Resistant Mechanisms Identified Using Serial Next-Generation Sequencing in a Patient With ALK-Rearranged Metastatic Lung Adenocarcinoma: A Case Report |
| title_fullStr | Diverse Resistant Mechanisms Identified Using Serial Next-Generation Sequencing in a Patient With ALK-Rearranged Metastatic Lung Adenocarcinoma: A Case Report |
| title_full_unstemmed | Diverse Resistant Mechanisms Identified Using Serial Next-Generation Sequencing in a Patient With ALK-Rearranged Metastatic Lung Adenocarcinoma: A Case Report |
| title_short | Diverse Resistant Mechanisms Identified Using Serial Next-Generation Sequencing in a Patient With ALK-Rearranged Metastatic Lung Adenocarcinoma: A Case Report |
| title_sort | diverse resistant mechanisms identified using serial next generation sequencing in a patient with alk rearranged metastatic lung adenocarcinoma a case report |
| topic | ALK Next-generation sequencing Resistant mechanisms Non–small cell lung cancer Case report |
| url | http://www.sciencedirect.com/science/article/pii/S2666364323000516 |
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