Diverse Resistant Mechanisms Identified Using Serial Next-Generation Sequencing in a Patient With ALK-Rearranged Metastatic Lung Adenocarcinoma: A Case Report

Diverse Resistant Mechanisms Identified Using Serial Next-Generation Sequencing in a Patient With ALK-Rearranged Metastatic Lung Adenocarcinoma: A Case Report

Both tissue and plasma-based next generation sequencing (NGS) facilitate the identification of actionable oncogene alterations at diagnosis and resistant mechanisms on progression. The value of longitudinal profiling is less established among patients with ALK-rearranged NSCLC, underpinned by concer...

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Bibliographic Details
Main Authors: Stephanie Pei Li Saw, MRCP, Darren Wan-Teck Lim, MRCP
Format: Article
Language:English
Published: Elsevier 2023-06-01
Series:JTO Clinical and Research Reports
Subjects:
ALK
Next-generation sequencing
Resistant mechanisms
Non–small cell lung cancer
Case report
Online Access:http://www.sciencedirect.com/science/article/pii/S2666364323000516

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