Drug synergy discovery of tavaborole and aminoglycosides against Escherichia coli using high throughput screening
Key points Benzoxaborole Compound Tavaborole was discovered against E. coli by using HTS. Tavaborole showed synergistic efficacy with aminoglycosides in vitro and in vivo. The main mechanism of synergy was promoting protein mistranslation mutually.
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SpringerOpen
2022-12-01
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| Series: | AMB Express |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13568-022-01488-6 |
| _version_ | 1797985483381276672 |
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| author | Shasha Liu Pengfei She Zehao Li Yimin Li Linhui Li Yifan Yang Linying Zhou Yong Wu |
| author_facet | Shasha Liu Pengfei She Zehao Li Yimin Li Linhui Li Yifan Yang Linying Zhou Yong Wu |
| author_sort | Shasha Liu |
| collection | DOAJ |
| description | Key points Benzoxaborole Compound Tavaborole was discovered against E. coli by using HTS. Tavaborole showed synergistic efficacy with aminoglycosides in vitro and in vivo. The main mechanism of synergy was promoting protein mistranslation mutually. |
| first_indexed | 2024-04-11T07:17:55Z |
| format | Article |
| id | doaj.art-913208a92e9d4082bc231ebd095ffbef |
| institution | Directory Open Access Journal |
| issn | 2191-0855 |
| language | English |
| last_indexed | 2024-04-11T07:17:55Z |
| publishDate | 2022-12-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | AMB Express |
| spelling | doaj.art-913208a92e9d4082bc231ebd095ffbef2022-12-22T04:37:51ZengSpringerOpenAMB Express2191-08552022-12-0112111710.1186/s13568-022-01488-6Drug synergy discovery of tavaborole and aminoglycosides against Escherichia coli using high throughput screeningShasha Liu0Pengfei She1Zehao Li2Yimin Li3Linhui Li4Yifan Yang5Linying Zhou6Yong Wu7Department of Laboratory Medicine, The Third Xiangya Hospital, Central South UniversityDepartment of Laboratory Medicine, The Third Xiangya Hospital, Central South UniversityDepartment of Laboratory Medicine, The Third Xiangya Hospital, Central South UniversityDepartment of Laboratory Medicine, The Third Xiangya Hospital, Central South UniversityDepartment of Laboratory Medicine, The Third Xiangya Hospital, Central South UniversityDepartment of Laboratory Medicine, The Third Xiangya Hospital, Central South UniversityDepartment of Laboratory Medicine, The Affiliated Changsha Hospital of Xiangya School of Medicine, Central South UniversityDepartment of Laboratory Medicine, The Affiliated Changsha Hospital of Xiangya School of Medicine, Central South UniversityKey points Benzoxaborole Compound Tavaborole was discovered against E. coli by using HTS. Tavaborole showed synergistic efficacy with aminoglycosides in vitro and in vivo. The main mechanism of synergy was promoting protein mistranslation mutually.https://doi.org/10.1186/s13568-022-01488-6Drug repurposingMicrobial proteomicsBenzoxaboroleDrug resistanceUropathogenic Escherichia col |
| spellingShingle | Shasha Liu Pengfei She Zehao Li Yimin Li Linhui Li Yifan Yang Linying Zhou Yong Wu Drug synergy discovery of tavaborole and aminoglycosides against Escherichia coli using high throughput screening AMB Express Drug repurposing Microbial proteomics Benzoxaborole Drug resistance Uropathogenic Escherichia col |
| title | Drug synergy discovery of tavaborole and aminoglycosides against Escherichia coli using high throughput screening |
| title_full | Drug synergy discovery of tavaborole and aminoglycosides against Escherichia coli using high throughput screening |
| title_fullStr | Drug synergy discovery of tavaborole and aminoglycosides against Escherichia coli using high throughput screening |
| title_full_unstemmed | Drug synergy discovery of tavaborole and aminoglycosides against Escherichia coli using high throughput screening |
| title_short | Drug synergy discovery of tavaborole and aminoglycosides against Escherichia coli using high throughput screening |
| title_sort | drug synergy discovery of tavaborole and aminoglycosides against escherichia coli using high throughput screening |
| topic | Drug repurposing Microbial proteomics Benzoxaborole Drug resistance Uropathogenic Escherichia col |
| url | https://doi.org/10.1186/s13568-022-01488-6 |
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