Drug synergy discovery of tavaborole and aminoglycosides against Escherichia coli using high throughput screening

Drug synergy discovery of tavaborole and aminoglycosides against Escherichia coli using high throughput screening

Key points Benzoxaborole Compound Tavaborole was discovered against E. coli by using HTS. Tavaborole showed synergistic efficacy with aminoglycosides in vitro and in vivo. The main mechanism of synergy was promoting protein mistranslation mutually.

Bibliographic Details
Main Authors: Shasha Liu, Pengfei She, Zehao Li, Yimin Li, Linhui Li, Yifan Yang, Linying Zhou, Yong Wu
Format: Article
Language:English
Published: SpringerOpen 2022-12-01
Series:AMB Express
Subjects:
Drug repurposing
Microbial proteomics
Benzoxaborole
Drug resistance
Uropathogenic Escherichia col
Online Access:https://doi.org/10.1186/s13568-022-01488-6

Internet

https://doi.org/10.1186/s13568-022-01488-6

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