Gender differences in insulin and C-peptide concentrations at birth using cord blood collection
ABSTRACT Objective To study gender differences in insulin and C-peptide concentrations at birth using cord blood collection. Subjects and methods This study was conducted in a maternity hospital, in Jammu province of Jammu and Kashmir, India. All women with pregnancy who were hospitalized for de...
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| Format: | Article |
| Language: | English |
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Brazilian Society of Endocrinology and Metabolism
2016-02-01
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| Series: | Archives of Endocrinology and Metabolism |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972016000300264&lng=en&tlng=en |
| _version_ | 1811199266639577088 |
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| author | Mohammad Shafi Kuchay Rattan P. Kudyar Anil Gupta Kamal Kishor Pandita Mohammad Ashraf Ganie |
| author_facet | Mohammad Shafi Kuchay Rattan P. Kudyar Anil Gupta Kamal Kishor Pandita Mohammad Ashraf Ganie |
| author_sort | Mohammad Shafi Kuchay |
| collection | DOAJ |
| description | ABSTRACT Objective To study gender differences in insulin and C-peptide concentrations at birth using cord blood collection. Subjects and methods This study was conducted in a maternity hospital, in Jammu province of Jammu and Kashmir, India. All women with pregnancy who were hospitalized for delivery were followed. All pregnant ladies who had no medical condition affecting insulin levels, as per history and routine antenatal blood testing, were included in the study. The test for cord plasma insulin and C-peptide was done in 60 (30 males) full-term (≥ 37 completed weeks) normal delivery babies within 4 hours of the collection of samples using the electro-chemiluminescence immunoassay (ECLIA) on Roche elecsys module immunoassay analyzer. Weight of the babies was taken immediately after birth using digital scales. Results Cord plasma insulin and C-peptide measured in EDTA were compared between boys and girls and also related to birth weight. Girls were lighter (2,830 ± 37 vs. 3,236 ± 46 g; p = < 0.001) but had higher cord insulin (16.48 ± 4.88 vs. 10.53 ± 4.04 µU/mL; p = < 0.001), and C-peptide (2.47 ± 0.66 vs. 0.834 ± 0.26 ng/mL; p = < 0.001) concentrations than newborn boys. Conclusion Female newborn babies have higher cord plasma insulin and C-peptide concentrations than male newborns, despite being smaller, suggesting intrinsic insulin resistance in girls. |
| first_indexed | 2024-04-12T01:45:00Z |
| format | Article |
| id | doaj.art-91356498f11b42398f9710b56233193f |
| institution | Directory Open Access Journal |
| issn | 2359-4292 |
| language | English |
| last_indexed | 2024-04-12T01:45:00Z |
| publishDate | 2016-02-01 |
| publisher | Brazilian Society of Endocrinology and Metabolism |
| record_format | Article |
| series | Archives of Endocrinology and Metabolism |
| spelling | doaj.art-91356498f11b42398f9710b56233193f2022-12-22T03:53:05ZengBrazilian Society of Endocrinology and MetabolismArchives of Endocrinology and Metabolism2359-42922016-02-0160326426610.1590/2359-3997000000148S2359-39972016000300264Gender differences in insulin and C-peptide concentrations at birth using cord blood collectionMohammad Shafi KuchayRattan P. KudyarAnil GuptaKamal Kishor PanditaMohammad Ashraf GanieABSTRACT Objective To study gender differences in insulin and C-peptide concentrations at birth using cord blood collection. Subjects and methods This study was conducted in a maternity hospital, in Jammu province of Jammu and Kashmir, India. All women with pregnancy who were hospitalized for delivery were followed. All pregnant ladies who had no medical condition affecting insulin levels, as per history and routine antenatal blood testing, were included in the study. The test for cord plasma insulin and C-peptide was done in 60 (30 males) full-term (≥ 37 completed weeks) normal delivery babies within 4 hours of the collection of samples using the electro-chemiluminescence immunoassay (ECLIA) on Roche elecsys module immunoassay analyzer. Weight of the babies was taken immediately after birth using digital scales. Results Cord plasma insulin and C-peptide measured in EDTA were compared between boys and girls and also related to birth weight. Girls were lighter (2,830 ± 37 vs. 3,236 ± 46 g; p = < 0.001) but had higher cord insulin (16.48 ± 4.88 vs. 10.53 ± 4.04 µU/mL; p = < 0.001), and C-peptide (2.47 ± 0.66 vs. 0.834 ± 0.26 ng/mL; p = < 0.001) concentrations than newborn boys. Conclusion Female newborn babies have higher cord plasma insulin and C-peptide concentrations than male newborns, despite being smaller, suggesting intrinsic insulin resistance in girls.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972016000300264&lng=en&tlng=enInsulin resistancecord plasma insulincord plasma C-peptidenewborn babies |
| spellingShingle | Mohammad Shafi Kuchay Rattan P. Kudyar Anil Gupta Kamal Kishor Pandita Mohammad Ashraf Ganie Gender differences in insulin and C-peptide concentrations at birth using cord blood collection Archives of Endocrinology and Metabolism Insulin resistance cord plasma insulin cord plasma C-peptide newborn babies |
| title | Gender differences in insulin and C-peptide concentrations at birth using cord blood collection |
| title_full | Gender differences in insulin and C-peptide concentrations at birth using cord blood collection |
| title_fullStr | Gender differences in insulin and C-peptide concentrations at birth using cord blood collection |
| title_full_unstemmed | Gender differences in insulin and C-peptide concentrations at birth using cord blood collection |
| title_short | Gender differences in insulin and C-peptide concentrations at birth using cord blood collection |
| title_sort | gender differences in insulin and c peptide concentrations at birth using cord blood collection |
| topic | Insulin resistance cord plasma insulin cord plasma C-peptide newborn babies |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972016000300264&lng=en&tlng=en |
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