Germ cell desquamation-based testis regression in a seasonal breeder, the Egyptian long-eared hedgehog, Hemiechinus auritus.
Testes of seasonally breeding species experience a severe functional regression before the non-breeding period, which implies a substantial mass reduction due to massive germ-cell depletion. Two alternative mechanisms of seasonal germ-cell depletion have been described in mammals, apoptosis and desq...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2018-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC6171879?pdf=render |
| _version_ | 1817994898232573952 |
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| author | Diaa Massoud Miguel Lao-Pérez Alicia Hurtado Walied Abdo Rogelio Palomino-Morales Francisco David Carmona Miguel Burgos Rafael Jiménez Francisco J Barrionuevo |
| author_facet | Diaa Massoud Miguel Lao-Pérez Alicia Hurtado Walied Abdo Rogelio Palomino-Morales Francisco David Carmona Miguel Burgos Rafael Jiménez Francisco J Barrionuevo |
| author_sort | Diaa Massoud |
| collection | DOAJ |
| description | Testes of seasonally breeding species experience a severe functional regression before the non-breeding period, which implies a substantial mass reduction due to massive germ-cell depletion. Two alternative mechanisms of seasonal germ-cell depletion have been described in mammals, apoptosis and desquamation (sloughing), but their prevalence has not been determined yet due to reduced number of species studied. We performed a morphological, hormonal, and molecular study of the mechanism of seasonal testicular regression in males of the Egyptian long eared-hedgehog (Hemiechinus auritus). Our results show that live, non-apoptotic, germ cells are massively depleted by desquamation during the testis regression process. This is concomitant with both decreased levels of serum testosterone and irregular distribution of the cell-adhesion molecules in the seminiferous epithelium. The inactive testes maintain some meiotic activity as meiosis onset is not halted and spermatocytes die by apoptosis at the pachytene stage. Our data support the notion that apoptosis is not the major testis regression effector in mammals. Instead, desquamation appears to be a common mechanism in this class. |
| first_indexed | 2024-04-14T01:58:10Z |
| format | Article |
| id | doaj.art-91360623498c4e9aa62d04cb20d0c5b5 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-14T01:58:10Z |
| publishDate | 2018-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-91360623498c4e9aa62d04cb20d0c5b52022-12-22T02:18:57ZengPublic Library of Science (PLoS)PLoS ONE1932-62032018-01-011310e020485110.1371/journal.pone.0204851Germ cell desquamation-based testis regression in a seasonal breeder, the Egyptian long-eared hedgehog, Hemiechinus auritus.Diaa MassoudMiguel Lao-PérezAlicia HurtadoWalied AbdoRogelio Palomino-MoralesFrancisco David CarmonaMiguel BurgosRafael JiménezFrancisco J BarrionuevoTestes of seasonally breeding species experience a severe functional regression before the non-breeding period, which implies a substantial mass reduction due to massive germ-cell depletion. Two alternative mechanisms of seasonal germ-cell depletion have been described in mammals, apoptosis and desquamation (sloughing), but their prevalence has not been determined yet due to reduced number of species studied. We performed a morphological, hormonal, and molecular study of the mechanism of seasonal testicular regression in males of the Egyptian long eared-hedgehog (Hemiechinus auritus). Our results show that live, non-apoptotic, germ cells are massively depleted by desquamation during the testis regression process. This is concomitant with both decreased levels of serum testosterone and irregular distribution of the cell-adhesion molecules in the seminiferous epithelium. The inactive testes maintain some meiotic activity as meiosis onset is not halted and spermatocytes die by apoptosis at the pachytene stage. Our data support the notion that apoptosis is not the major testis regression effector in mammals. Instead, desquamation appears to be a common mechanism in this class.http://europepmc.org/articles/PMC6171879?pdf=render |
| spellingShingle | Diaa Massoud Miguel Lao-Pérez Alicia Hurtado Walied Abdo Rogelio Palomino-Morales Francisco David Carmona Miguel Burgos Rafael Jiménez Francisco J Barrionuevo Germ cell desquamation-based testis regression in a seasonal breeder, the Egyptian long-eared hedgehog, Hemiechinus auritus. PLoS ONE |
| title | Germ cell desquamation-based testis regression in a seasonal breeder, the Egyptian long-eared hedgehog, Hemiechinus auritus. |
| title_full | Germ cell desquamation-based testis regression in a seasonal breeder, the Egyptian long-eared hedgehog, Hemiechinus auritus. |
| title_fullStr | Germ cell desquamation-based testis regression in a seasonal breeder, the Egyptian long-eared hedgehog, Hemiechinus auritus. |
| title_full_unstemmed | Germ cell desquamation-based testis regression in a seasonal breeder, the Egyptian long-eared hedgehog, Hemiechinus auritus. |
| title_short | Germ cell desquamation-based testis regression in a seasonal breeder, the Egyptian long-eared hedgehog, Hemiechinus auritus. |
| title_sort | germ cell desquamation based testis regression in a seasonal breeder the egyptian long eared hedgehog hemiechinus auritus |
| url | http://europepmc.org/articles/PMC6171879?pdf=render |
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