Assessment of the risk factors associated with multidrug-resistant tuberculosis in Sudan: a case-control study
OBJECTIVES The emergence of multidrug-resistant tuberculosis (MDR-TB) is a major challenge for the global control of tuberculosis (TB). The aim of this study was to determine the risk factors associated with MDR-TB in Sudan. METHODS This case-control study was conducted from May 2017 to February 201...
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| Format: | Article |
| Language: | English |
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Korean Society of Epidemiology
2019-04-01
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| Series: | Epidemiology and Health |
| Subjects: | |
| Online Access: | http://e-epih.org/upload/pdf/epih-41-e2019014.pdf |
| _version_ | 1818380973829521408 |
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| author | Adel Hussein Elduma Mohammad Ali Mansournia Abbas Rahimi Foroushani Hamdan Mustafa Hamdan Ali Asrar M A/Salam Elegail Asma Elsony Kourosh Holakouie-Naieni |
| author_facet | Adel Hussein Elduma Mohammad Ali Mansournia Abbas Rahimi Foroushani Hamdan Mustafa Hamdan Ali Asrar M A/Salam Elegail Asma Elsony Kourosh Holakouie-Naieni |
| author_sort | Adel Hussein Elduma |
| collection | DOAJ |
| description | OBJECTIVES The emergence of multidrug-resistant tuberculosis (MDR-TB) is a major challenge for the global control of tuberculosis (TB). The aim of this study was to determine the risk factors associated with MDR-TB in Sudan. METHODS This case-control study was conducted from May 2017 to February 2019. Patients newly diagnosed with MDR-TB were selected as cases, and controls were selected from TB patients who responded to first-line anti-TB drugs. A questionnaire was designed and used to collect data from study participants. Logistic regression was used to evaluate associations between risk factors and MDR-TB infection. The best multivariate model was selected based on the likelihood ratio test. RESULTS A total of 430 cases and 860 controls were selected for this study. A history of previous TB treatment (adjusted odds ratio [aOR], 54.85; 95% confidence interval [CI], 30.48 to 98.69) was strongly associated with MDR-TB infection. We identified interruption of TB treatment (aOR, 7.62; 95% CI, 3.16 to 18.34), contact with MDR-TB patients (aOR, 5.40; 95% CI, 2.69 to 10.74), lower body weight (aOR, 0.89; 95% CI, 0.87 to 0.91), and water pipe smoking (aOR, 3.23; 95% CI, 1.73 to 6.04) as factors associated with MDR-TB infection. CONCLUSIONS Previous TB treatment and interruption of TB treatment were found to be the main predictors of MDR-TB. Additionally, this study found that contact with MDR-TB patients and water pipe smoking were associated with MDR-TB infection in Sudan. More efforts are required to decrease the rate of treatment interruption, to strengthen patients’ adherence to treatment, and to reduce contact with MDR-TB patients. |
| first_indexed | 2024-12-14T02:27:12Z |
| format | Article |
| id | doaj.art-9136691dd3a244888bfb7072133d58b5 |
| institution | Directory Open Access Journal |
| issn | 2092-7193 |
| language | English |
| last_indexed | 2024-12-14T02:27:12Z |
| publishDate | 2019-04-01 |
| publisher | Korean Society of Epidemiology |
| record_format | Article |
| series | Epidemiology and Health |
| spelling | doaj.art-9136691dd3a244888bfb7072133d58b52022-12-21T23:20:21ZengKorean Society of EpidemiologyEpidemiology and Health2092-71932019-04-014110.4178/epih.e20190141029Assessment of the risk factors associated with multidrug-resistant tuberculosis in Sudan: a case-control studyAdel Hussein Elduma0Mohammad Ali Mansournia1Abbas Rahimi Foroushani2Hamdan Mustafa Hamdan Ali3Asrar M A/Salam Elegail4Asma Elsony5Kourosh Holakouie-Naieni6 Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences-International Campus, Tehran, Iran Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran Multidrug-Resistant Tuberculosis Unit, Communicable and Non-Communicable Diseases Control Directorate, Ministry of Health, Khartoum, Sudan National Tuberculosis Reference Laboratory, National Public Health Laboratory, Ministry of Health, Khartoum, Sudan The Epidemiological Laboratory (Epi-Lab), Khartoum, Sudan Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, IranOBJECTIVES The emergence of multidrug-resistant tuberculosis (MDR-TB) is a major challenge for the global control of tuberculosis (TB). The aim of this study was to determine the risk factors associated with MDR-TB in Sudan. METHODS This case-control study was conducted from May 2017 to February 2019. Patients newly diagnosed with MDR-TB were selected as cases, and controls were selected from TB patients who responded to first-line anti-TB drugs. A questionnaire was designed and used to collect data from study participants. Logistic regression was used to evaluate associations between risk factors and MDR-TB infection. The best multivariate model was selected based on the likelihood ratio test. RESULTS A total of 430 cases and 860 controls were selected for this study. A history of previous TB treatment (adjusted odds ratio [aOR], 54.85; 95% confidence interval [CI], 30.48 to 98.69) was strongly associated with MDR-TB infection. We identified interruption of TB treatment (aOR, 7.62; 95% CI, 3.16 to 18.34), contact with MDR-TB patients (aOR, 5.40; 95% CI, 2.69 to 10.74), lower body weight (aOR, 0.89; 95% CI, 0.87 to 0.91), and water pipe smoking (aOR, 3.23; 95% CI, 1.73 to 6.04) as factors associated with MDR-TB infection. CONCLUSIONS Previous TB treatment and interruption of TB treatment were found to be the main predictors of MDR-TB. Additionally, this study found that contact with MDR-TB patients and water pipe smoking were associated with MDR-TB infection in Sudan. More efforts are required to decrease the rate of treatment interruption, to strengthen patients’ adherence to treatment, and to reduce contact with MDR-TB patients.http://e-epih.org/upload/pdf/epih-41-e2019014.pdfrisk factorstuberculosismultidrug resistantsudan |
| spellingShingle | Adel Hussein Elduma Mohammad Ali Mansournia Abbas Rahimi Foroushani Hamdan Mustafa Hamdan Ali Asrar M A/Salam Elegail Asma Elsony Kourosh Holakouie-Naieni Assessment of the risk factors associated with multidrug-resistant tuberculosis in Sudan: a case-control study Epidemiology and Health risk factors tuberculosis multidrug resistant sudan |
| title | Assessment of the risk factors associated with multidrug-resistant tuberculosis in Sudan: a case-control study |
| title_full | Assessment of the risk factors associated with multidrug-resistant tuberculosis in Sudan: a case-control study |
| title_fullStr | Assessment of the risk factors associated with multidrug-resistant tuberculosis in Sudan: a case-control study |
| title_full_unstemmed | Assessment of the risk factors associated with multidrug-resistant tuberculosis in Sudan: a case-control study |
| title_short | Assessment of the risk factors associated with multidrug-resistant tuberculosis in Sudan: a case-control study |
| title_sort | assessment of the risk factors associated with multidrug resistant tuberculosis in sudan a case control study |
| topic | risk factors tuberculosis multidrug resistant sudan |
| url | http://e-epih.org/upload/pdf/epih-41-e2019014.pdf |
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