Role of Natural Killer Cells during Pregnancy and Related Complications
A high number of leucocytes reside in the human endometrium and are distributed differentially during the menstrual cycle and pregnancy. During early pregnancy, decidual natural killer (dNK) cells are the most common type of natural killer (NK) cells in the uterus. The increase in the number of uter...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-01-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/12/1/68 |
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| author | Deviyani Mahajan Neeta Raj Sharma Sudhakar Kancharla Prachetha Kolli Ashutosh Tripathy Amarish Kumar Sharma Sanjeev Singh Sudarshan Kumar Ashok Kumar Mohanty Manoj Kumar Jena |
| author_facet | Deviyani Mahajan Neeta Raj Sharma Sudhakar Kancharla Prachetha Kolli Ashutosh Tripathy Amarish Kumar Sharma Sanjeev Singh Sudarshan Kumar Ashok Kumar Mohanty Manoj Kumar Jena |
| author_sort | Deviyani Mahajan |
| collection | DOAJ |
| description | A high number of leucocytes reside in the human endometrium and are distributed differentially during the menstrual cycle and pregnancy. During early pregnancy, decidual natural killer (dNK) cells are the most common type of natural killer (NK) cells in the uterus. The increase in the number of uterine NK (uNK) cells during the mid-secretory phase of the menstrual cycle, followed by further increase of dNK cells in early pregnancy, has heightened interest in their involvement during pregnancy. Extensive research has revealed various roles of dNK cells during pregnancy including the formation of new blood vessels, migration of trophoblasts, and immunological tolerance. The present review article is focused on the significance of NK cells during pregnancy and their role in pregnancy-related diseases. The article will provide an in-depth review of cellular and molecular interactions during pregnancy and related disorders, with NK cells playing a pivotal role. Moreover, this study will help researchers to understand the physiology of normal pregnancy and related complications with respect to NK cells, so that future research work can be designed to alleviate the complications. |
| first_indexed | 2024-03-10T01:50:12Z |
| format | Article |
| id | doaj.art-9138d1a3440b40dd9d90df57ca3d277c |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-10T01:50:12Z |
| publishDate | 2022-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-9138d1a3440b40dd9d90df57ca3d277c2023-11-23T13:06:34ZengMDPI AGBiomolecules2218-273X2022-01-011216810.3390/biom12010068Role of Natural Killer Cells during Pregnancy and Related ComplicationsDeviyani Mahajan0Neeta Raj Sharma1Sudhakar Kancharla2Prachetha Kolli3Ashutosh Tripathy4Amarish Kumar Sharma5Sanjeev Singh6Sudarshan Kumar7Ashok Kumar Mohanty8Manoj Kumar Jena9Department of Biotechnology, School of Bioengineering and Biosciences, Lovely Professional University, Phagwara 144411, Punjab, IndiaDepartment of Biotechnology, School of Bioengineering and Biosciences, Lovely Professional University, Phagwara 144411, Punjab, IndiaDevansh Lab Werks, 234 Aquarius Drive, Homewood, AL 35209, USAMicrogen Health Inc., 14225 Sullyfield Cir Suite E, Chantilly, VA 20151, USADepartment of Biotechnology, School of Bioengineering and Biosciences, Lovely Professional University, Phagwara 144411, Punjab, IndiaDepartment of Biotechnology, School of Bioengineering and Biosciences, Lovely Professional University, Phagwara 144411, Punjab, IndiaDepartment of Biotechnology, School of Bioengineering and Biosciences, Lovely Professional University, Phagwara 144411, Punjab, IndiaAnimal Biotechnology Centre, National Dairy Research Institute, Karnal 132001, Haryana, IndiaIndian Veterinary Research Institute, Mukteswar Campus, Mukteswar 263138, Uttarakhand, IndiaDepartment of Biotechnology, School of Bioengineering and Biosciences, Lovely Professional University, Phagwara 144411, Punjab, IndiaA high number of leucocytes reside in the human endometrium and are distributed differentially during the menstrual cycle and pregnancy. During early pregnancy, decidual natural killer (dNK) cells are the most common type of natural killer (NK) cells in the uterus. The increase in the number of uterine NK (uNK) cells during the mid-secretory phase of the menstrual cycle, followed by further increase of dNK cells in early pregnancy, has heightened interest in their involvement during pregnancy. Extensive research has revealed various roles of dNK cells during pregnancy including the formation of new blood vessels, migration of trophoblasts, and immunological tolerance. The present review article is focused on the significance of NK cells during pregnancy and their role in pregnancy-related diseases. The article will provide an in-depth review of cellular and molecular interactions during pregnancy and related disorders, with NK cells playing a pivotal role. Moreover, this study will help researchers to understand the physiology of normal pregnancy and related complications with respect to NK cells, so that future research work can be designed to alleviate the complications.https://www.mdpi.com/2218-273X/12/1/68naturalkiller cellsendometriumpregnancydecidual angiogenesispreeclampsia |
| spellingShingle | Deviyani Mahajan Neeta Raj Sharma Sudhakar Kancharla Prachetha Kolli Ashutosh Tripathy Amarish Kumar Sharma Sanjeev Singh Sudarshan Kumar Ashok Kumar Mohanty Manoj Kumar Jena Role of Natural Killer Cells during Pregnancy and Related Complications Biomolecules naturalkiller cells endometrium pregnancy decidual angiogenesis preeclampsia |
| title | Role of Natural Killer Cells during Pregnancy and Related Complications |
| title_full | Role of Natural Killer Cells during Pregnancy and Related Complications |
| title_fullStr | Role of Natural Killer Cells during Pregnancy and Related Complications |
| title_full_unstemmed | Role of Natural Killer Cells during Pregnancy and Related Complications |
| title_short | Role of Natural Killer Cells during Pregnancy and Related Complications |
| title_sort | role of natural killer cells during pregnancy and related complications |
| topic | naturalkiller cells endometrium pregnancy decidual angiogenesis preeclampsia |
| url | https://www.mdpi.com/2218-273X/12/1/68 |
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