An effective restoration of one-carbon metabolism in folate-deficient mice with a high-folate corn inbred line
Since folic acid (FA) was officially recommended in 1998, concerns have emerged about the effect of excess FA intake, in particular with respect to negative clinical effects. Given this, a high-folate corn inbred line that we identified from a global germplasm collection was believed to become a val...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-12-01
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| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464622003875 |
| _version_ | 1811179073028751360 |
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| author | Xiaolin Lu Ling Jiang Qizong Zhang Junshen Huo Jie Min Qiuju Liang Lijiao Zhao Yan Li Shaoyan Chang Ting Zhang Chunyi Zhang Li Wang |
| author_facet | Xiaolin Lu Ling Jiang Qizong Zhang Junshen Huo Jie Min Qiuju Liang Lijiao Zhao Yan Li Shaoyan Chang Ting Zhang Chunyi Zhang Li Wang |
| author_sort | Xiaolin Lu |
| collection | DOAJ |
| description | Since folic acid (FA) was officially recommended in 1998, concerns have emerged about the effect of excess FA intake, in particular with respect to negative clinical effects. Given this, a high-folate corn inbred line that we identified from a global germplasm collection was believed to become a valid alternative to FA supplementation. In this study, we proved this natural form of plant-sourced folates exhibited an effective restoration of folate deficiency. Folate metabolism and methylation modifications were restored in folate-deficient mice with folate-supplemented diets in 4 weeks. Restoration effects varies depending on folate sources, restricted retrotransposon activity and an orderly pattern of phospholipid/lipid metabolism protected by this high-folate corn partly ensures a healthy folate status for development. Totally, we proved in mice models that this kind of folate biofortification corn could provide a valid alternation of FA supplementation in alleviation of folate deficiency during pregnancy. |
| first_indexed | 2024-04-11T06:28:25Z |
| format | Article |
| id | doaj.art-9138eface9a84a0fa8aee11337b9855e |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-04-11T06:28:25Z |
| publishDate | 2022-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-9138eface9a84a0fa8aee11337b9855e2022-12-22T04:40:15ZengElsevierJournal of Functional Foods1756-46462022-12-0199105317An effective restoration of one-carbon metabolism in folate-deficient mice with a high-folate corn inbred lineXiaolin Lu0Ling Jiang1Qizong Zhang2Junshen Huo3Jie Min4Qiuju Liang5Lijiao Zhao6Yan Li7Shaoyan Chang8Ting Zhang9Chunyi Zhang10Li Wang11Municipal Key Laboratory of Child Development and Nutriomics, Capital Institute of Pediatrics, Beijing, ChinaBiotechnology Research Institute, Chinese Academy of Agricultural Sciences, Beijing, ChinaCollege of Life Science and Bioengineering, Beijing University of Technology, Beijing, ChinaNational Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, Beijing, ChinaMunicipal Key Laboratory of Child Development and Nutriomics, Capital Institute of Pediatrics, Beijing, ChinaBiotechnology Research Institute, Chinese Academy of Agricultural Sciences, Beijing, ChinaCollege of Life Science and Bioengineering, Beijing University of Technology, Beijing, ChinaNational Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, Beijing, ChinaMunicipal Key Laboratory of Child Development and Nutriomics, Capital Institute of Pediatrics, Beijing, ChinaMunicipal Key Laboratory of Child Development and Nutriomics, Capital Institute of Pediatrics, Beijing, ChinaBiotechnology Research Institute, Chinese Academy of Agricultural Sciences, Beijing, China; Sanya Institute, Hainan Academy of Agricultural Sciences, Sanya, China; Corresponding authors at: Municipal Key Laboratory of Child Development and Nutriomics, Capital Institute of Pediatrics, Beijing, China (L. Wang). Biotechnology Research Institute, Chinese Academy of Agricultural Sciences, Beijing, China (C. Zhang).Municipal Key Laboratory of Child Development and Nutriomics, Capital Institute of Pediatrics, Beijing, China; Corresponding authors at: Municipal Key Laboratory of Child Development and Nutriomics, Capital Institute of Pediatrics, Beijing, China (L. Wang). Biotechnology Research Institute, Chinese Academy of Agricultural Sciences, Beijing, China (C. Zhang).Since folic acid (FA) was officially recommended in 1998, concerns have emerged about the effect of excess FA intake, in particular with respect to negative clinical effects. Given this, a high-folate corn inbred line that we identified from a global germplasm collection was believed to become a valid alternative to FA supplementation. In this study, we proved this natural form of plant-sourced folates exhibited an effective restoration of folate deficiency. Folate metabolism and methylation modifications were restored in folate-deficient mice with folate-supplemented diets in 4 weeks. Restoration effects varies depending on folate sources, restricted retrotransposon activity and an orderly pattern of phospholipid/lipid metabolism protected by this high-folate corn partly ensures a healthy folate status for development. Totally, we proved in mice models that this kind of folate biofortification corn could provide a valid alternation of FA supplementation in alleviation of folate deficiency during pregnancy.http://www.sciencedirect.com/science/article/pii/S1756464622003875Folic Acid (FA)DNA MethylationHigh-Folate CornLong Interspersed Nucleotide Element-1 (LINE-1)Lipid Metabolism |
| spellingShingle | Xiaolin Lu Ling Jiang Qizong Zhang Junshen Huo Jie Min Qiuju Liang Lijiao Zhao Yan Li Shaoyan Chang Ting Zhang Chunyi Zhang Li Wang An effective restoration of one-carbon metabolism in folate-deficient mice with a high-folate corn inbred line Journal of Functional Foods Folic Acid (FA) DNA Methylation High-Folate Corn Long Interspersed Nucleotide Element-1 (LINE-1) Lipid Metabolism |
| title | An effective restoration of one-carbon metabolism in folate-deficient mice with a high-folate corn inbred line |
| title_full | An effective restoration of one-carbon metabolism in folate-deficient mice with a high-folate corn inbred line |
| title_fullStr | An effective restoration of one-carbon metabolism in folate-deficient mice with a high-folate corn inbred line |
| title_full_unstemmed | An effective restoration of one-carbon metabolism in folate-deficient mice with a high-folate corn inbred line |
| title_short | An effective restoration of one-carbon metabolism in folate-deficient mice with a high-folate corn inbred line |
| title_sort | effective restoration of one carbon metabolism in folate deficient mice with a high folate corn inbred line |
| topic | Folic Acid (FA) DNA Methylation High-Folate Corn Long Interspersed Nucleotide Element-1 (LINE-1) Lipid Metabolism |
| url | http://www.sciencedirect.com/science/article/pii/S1756464622003875 |
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