Total enzymatic synthesis of cis-α-irone from a simple carbon source
Retrosynthetic pathway design using promiscuous enzymes can provide a solution to the biosynthetic production of natural products. Here, the authors design a pathway for the production of cis-α-irone with a promiscuous methyltransferase using structure-guided enzyme engineering strategies.
Main Authors: | Xixian Chen, Rehka T, Jérémy Esque, Congqiang Zhang, Sudha Shukal, Chin Chin Lim, Leonard Ong, Derek Smith, Isabelle André |
---|---|
Format: | Article |
Language: | English |
Published: |
Nature Portfolio
2022-12-01
|
Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-022-35232-2 |
Similar Items
-
Mediating oxidative stress enhances α-ionone biosynthesis and strain robustness during process scaling up
by: Ching-Ning Huang, et al.
Published: (2022-11-01) -
Real-time monitoring for brain tissue deformation during surgery
by: Shukal, Sudha.
Published: (2013) -
Classification of medical images for disease diagnosis
by: Sudha Devi Manbahal Shukal.
Published: (2009) -
Advances and applications of CRISPR/Cas-mediated interference in Escherichia coli
by: Xiaohui Lim, et al.
Published: (2024-03-01) -
Sustainable biosynthesis of valuable diterpenes in microbes
by: Yanbin Liu, et al.
Published: (2023-03-01)