Beyond Antagonism: The Interaction Between <i>Candida</i> Species and <i>Pseudomonas aeruginosa</i>
There are many examples of the interaction between prokaryotes and eukaryotes. One such example is the polymicrobial colonization/infection by the various opportunistic pathogenic yeasts belonging to the genus <i>Candida</i> and the ubiquitous bacterium, <i>Pseudomonas aeruginosa&l...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2019-04-01
|
| Series: | Journal of Fungi |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2309-608X/5/2/34 |
| _version_ | 1819040331244503040 |
|---|---|
| author | Ruan Fourie Carolina H. Pohl |
| author_facet | Ruan Fourie Carolina H. Pohl |
| author_sort | Ruan Fourie |
| collection | DOAJ |
| description | There are many examples of the interaction between prokaryotes and eukaryotes. One such example is the polymicrobial colonization/infection by the various opportunistic pathogenic yeasts belonging to the genus <i>Candida</i> and the ubiquitous bacterium, <i>Pseudomonas aeruginosa</i>. Although this interaction has simplistically been characterized as antagonistic to the yeast, this review highlights the complexity of the interaction with various factors influencing both microbes. The first section deals with the interactions <i>in vitro</i>, looking specifically at the role of cell wall components, quorum sensing molecules, phenazines, fatty acid metabolites and competition for iron in the interaction. The second part of this review places all these interactions in the context of various infection or colonization sites, i.e., lungs, wounds, and the gastrointestinal tract. Here we see that the role of the host, as well as the methodology used to establish co-infection, are important factors, influencing the outcome of the disease. Suggested future perspectives for the study of this interaction include determining the influence of newly identified participants of the QS network of <i>P. aeruginosa</i>, oxylipin production by both species, as well as the genetic and phenotypic plasticity of these microbes, on the interaction and outcome of co-infection. |
| first_indexed | 2024-12-21T09:07:24Z |
| format | Article |
| id | doaj.art-913b4798bfba428bac180d7b1b6fde02 |
| institution | Directory Open Access Journal |
| issn | 2309-608X |
| language | English |
| last_indexed | 2024-12-21T09:07:24Z |
| publishDate | 2019-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Fungi |
| spelling | doaj.art-913b4798bfba428bac180d7b1b6fde022022-12-21T19:09:19ZengMDPI AGJournal of Fungi2309-608X2019-04-01523410.3390/jof5020034jof5020034Beyond Antagonism: The Interaction Between <i>Candida</i> Species and <i>Pseudomonas aeruginosa</i>Ruan Fourie0Carolina H. Pohl1Department of Microbial, Biochemical and Food Biotechnology, University of the Free State, Bloemfontein 9301, South AfricaDepartment of Microbial, Biochemical and Food Biotechnology, University of the Free State, Bloemfontein 9301, South AfricaThere are many examples of the interaction between prokaryotes and eukaryotes. One such example is the polymicrobial colonization/infection by the various opportunistic pathogenic yeasts belonging to the genus <i>Candida</i> and the ubiquitous bacterium, <i>Pseudomonas aeruginosa</i>. Although this interaction has simplistically been characterized as antagonistic to the yeast, this review highlights the complexity of the interaction with various factors influencing both microbes. The first section deals with the interactions <i>in vitro</i>, looking specifically at the role of cell wall components, quorum sensing molecules, phenazines, fatty acid metabolites and competition for iron in the interaction. The second part of this review places all these interactions in the context of various infection or colonization sites, i.e., lungs, wounds, and the gastrointestinal tract. Here we see that the role of the host, as well as the methodology used to establish co-infection, are important factors, influencing the outcome of the disease. Suggested future perspectives for the study of this interaction include determining the influence of newly identified participants of the QS network of <i>P. aeruginosa</i>, oxylipin production by both species, as well as the genetic and phenotypic plasticity of these microbes, on the interaction and outcome of co-infection.https://www.mdpi.com/2309-608X/5/2/34<i>Candida albicans</i>interaction<i>Pseudomonas aeruginosa</i> |
| spellingShingle | Ruan Fourie Carolina H. Pohl Beyond Antagonism: The Interaction Between <i>Candida</i> Species and <i>Pseudomonas aeruginosa</i> Journal of Fungi <i>Candida albicans</i> interaction <i>Pseudomonas aeruginosa</i> |
| title | Beyond Antagonism: The Interaction Between <i>Candida</i> Species and <i>Pseudomonas aeruginosa</i> |
| title_full | Beyond Antagonism: The Interaction Between <i>Candida</i> Species and <i>Pseudomonas aeruginosa</i> |
| title_fullStr | Beyond Antagonism: The Interaction Between <i>Candida</i> Species and <i>Pseudomonas aeruginosa</i> |
| title_full_unstemmed | Beyond Antagonism: The Interaction Between <i>Candida</i> Species and <i>Pseudomonas aeruginosa</i> |
| title_short | Beyond Antagonism: The Interaction Between <i>Candida</i> Species and <i>Pseudomonas aeruginosa</i> |
| title_sort | beyond antagonism the interaction between i candida i species and i pseudomonas aeruginosa i |
| topic | <i>Candida albicans</i> interaction <i>Pseudomonas aeruginosa</i> |
| url | https://www.mdpi.com/2309-608X/5/2/34 |
| work_keys_str_mv | AT ruanfourie beyondantagonismtheinteractionbetweenicandidaispeciesandipseudomonasaeruginosai AT carolinahpohl beyondantagonismtheinteractionbetweenicandidaispeciesandipseudomonasaeruginosai |