Mesoporous Silica Nanoparticles for Targeting Subcellular Organelles
Current chemotherapy treatments lack great selectivity towards tumoral cells, which leads to nonspecific drug distribution and subsequent side effects. In this regard, the use of nanoparticles able to encapsulate and release therapeutic agents has attracted growing attention. In this sense, mesoporo...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-12-01
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| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/21/24/9696 |
| _version_ | 1797544150228271104 |
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| author | Miguel Gisbert-Garzarán Daniel Lozano María Vallet-Regí |
| author_facet | Miguel Gisbert-Garzarán Daniel Lozano María Vallet-Regí |
| author_sort | Miguel Gisbert-Garzarán |
| collection | DOAJ |
| description | Current chemotherapy treatments lack great selectivity towards tumoral cells, which leads to nonspecific drug distribution and subsequent side effects. In this regard, the use of nanoparticles able to encapsulate and release therapeutic agents has attracted growing attention. In this sense, mesoporous silica nanoparticles (MSNs) have been widely employed as drug carriers owing to their exquisite physico-chemical properties. Because MSNs present a surface full of silanol groups, they can be easily functionalized to endow the nanoparticles with many different functionalities, including the introduction of moieties with affinity for the cell membrane or relevant compartments within the cell, thus increasing the efficacy of the treatments. This review manuscript will provide the state-of-the-art on MSNs functionalized for targeting subcellular compartments, focusing on the cytoplasm, the mitochondria, and the nucleus. |
| first_indexed | 2024-03-10T13:56:21Z |
| format | Article |
| id | doaj.art-913e3370ef544807ad59321ebbc83333 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T13:56:21Z |
| publishDate | 2020-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-913e3370ef544807ad59321ebbc833332023-11-21T01:35:18ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-12-012124969610.3390/ijms21249696Mesoporous Silica Nanoparticles for Targeting Subcellular OrganellesMiguel Gisbert-Garzarán0Daniel Lozano1María Vallet-Regí2Departamento de Química en Ciencias Farmacéuticas, Instituto de Investigación Sanitaria Hospital 12 de Octubre i + 12, Universidad Complutense de Madrid, Plaza Ramón y Cajal s/n, 28040 Madrid, SpainDepartamento de Química en Ciencias Farmacéuticas, Instituto de Investigación Sanitaria Hospital 12 de Octubre i + 12, Universidad Complutense de Madrid, Plaza Ramón y Cajal s/n, 28040 Madrid, SpainDepartamento de Química en Ciencias Farmacéuticas, Instituto de Investigación Sanitaria Hospital 12 de Octubre i + 12, Universidad Complutense de Madrid, Plaza Ramón y Cajal s/n, 28040 Madrid, SpainCurrent chemotherapy treatments lack great selectivity towards tumoral cells, which leads to nonspecific drug distribution and subsequent side effects. In this regard, the use of nanoparticles able to encapsulate and release therapeutic agents has attracted growing attention. In this sense, mesoporous silica nanoparticles (MSNs) have been widely employed as drug carriers owing to their exquisite physico-chemical properties. Because MSNs present a surface full of silanol groups, they can be easily functionalized to endow the nanoparticles with many different functionalities, including the introduction of moieties with affinity for the cell membrane or relevant compartments within the cell, thus increasing the efficacy of the treatments. This review manuscript will provide the state-of-the-art on MSNs functionalized for targeting subcellular compartments, focusing on the cytoplasm, the mitochondria, and the nucleus.https://www.mdpi.com/1422-0067/21/24/9696mesoporous silica nanoparticlestargetingsubcellular targetingendosomal escapemitochondrianucleus |
| spellingShingle | Miguel Gisbert-Garzarán Daniel Lozano María Vallet-Regí Mesoporous Silica Nanoparticles for Targeting Subcellular Organelles International Journal of Molecular Sciences mesoporous silica nanoparticles targeting subcellular targeting endosomal escape mitochondria nucleus |
| title | Mesoporous Silica Nanoparticles for Targeting Subcellular Organelles |
| title_full | Mesoporous Silica Nanoparticles for Targeting Subcellular Organelles |
| title_fullStr | Mesoporous Silica Nanoparticles for Targeting Subcellular Organelles |
| title_full_unstemmed | Mesoporous Silica Nanoparticles for Targeting Subcellular Organelles |
| title_short | Mesoporous Silica Nanoparticles for Targeting Subcellular Organelles |
| title_sort | mesoporous silica nanoparticles for targeting subcellular organelles |
| topic | mesoporous silica nanoparticles targeting subcellular targeting endosomal escape mitochondria nucleus |
| url | https://www.mdpi.com/1422-0067/21/24/9696 |
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